Stem Cells Differentiation Articles & Analysis
18 articles found
Unlocking the Power of Organoids Organoids are three-dimensional structures that replicate the functions of actual organs within the body. They develop from progenitor cells, which researchers obtain either from embryonic tissues or pluripotent stem cells (PSCs). ...
By designing custom mRNA molecules, researchers can steer stem cell differentiation towards specific cell types, offering promising prospects in treating conditions such as spinal cord injuries and muscular dystrophy. This precision in directing cell development has the potential to revolutionize the field of ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. Benefits and advantages of iPSC ...
By creating cell banks of in vitro immortalized, primary-like cells from different tissues and donors with diverse genetic backgrounds, you are enable to perform their research on more than one individual cell line. ...
Pluripotent stem cells — cells with the ability to differentiate into nearly any cell type in the body, constituting a significant potential for regenerative medicine. Among these, induced Pluripotent Stem Cells (iPSCs), in particular, have garnered substantial interest ...
These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cells, epidermal cells, and fibroblasts) upon specific stimulation. ...
In addition to this basic function, RNA-seq can be used for differential gene expression, variant detection and allele-specific expression, small RNA profiling, characterization of alternative splicing patterns, system biology, and single-cell RNA-seq. ...
Explore how surgeons are using COREX to harvest cancellous bone graft using a minimally invasive ...
RNA Sequencing in Cardiovascular Disease Research The use of scRNA-seq technology in cardiovascular research has a wide range of applications. scRNA-seq not only identifies rare cell subpopulations, but it also allows for cellular trajectory analysis based on each cell's transcriptome, which has been particularly beneficial in clarifying cell ...
A new study clarifies how BRD4 (a protein that scientists have studied for many years) directs the spatial organization of DNA in the cell nucleus (a key function of stem cells to differentiate into muscle cells), which promotes the understanding of certain cancers and complex congenital diseases. ...
Niches in the Gut Throughout the entirety of the intestine, stem cells reside in pockets referred to as crypts. Gradients in extracellular matrix components, as well as matrix stiffness and the presence of physical binding sites, allow the stem cells to establish themselves within these niches in the intestine and coexist with ...
This single-cell-type model allows for investigation into the physiology of intestinal epithelial cells as proliferative stem or differentiated cell types, depending on the researchers’ interest. ...
The RepliGut® platform produces a polarized monolayer of human intestinal stem and differentiated cells — either of the large or small intestine — that can be used for modeling diseases or screening compounds for effects on the intestine. ...
Gene expression profiles in 10-μm pixels conformed into the clusters of single-cell transcriptomes, allowing for rapid identification of cell types and spatial distributions. ...
Currently, most RepliGut® assays are fairly short-lived; after the stem cells are differentiated, there are no more dividing cells and the cells are all terminal. ...
Before it is possible to understand what those roles are, it is necessary to understand the basic biology of stem cells: how they work and how they renew themselves and differentiate. ...
Mesenchymal stem cells (MSC) differentiate towards multiple lineages that participate in bone formation and are often utilized for bone regeneration therapy. ...
The execution of this regulatory code is what allows for the creation of very different cell- and tissue-types from the same set of genetic instructions found in the nucleus of every cell. ...