Stratum Corneum Articles & Analysis
9 articles found
Hollow microneedles offer the advantages of bypassing the stratum corneum and targeting specific dermal layers or tissues. Furthermore, they provide options for on-demand drug release and personalized medicine applications. ...
PVA also enhances drug permeation through the skin by hydrating the stratum corneum, thus increasing its flexibility and improving drug diffusion. ...
After piercing the skin, the needles made of degradable materials will gradually degrade in the microenvironment, and the drugs will be released synchronously. Molecules pass through the stratum corneum barrier and are absorbed into the body through the subcutaneous tissue. ...
Ceramides and skin Mechanism of skin barrier maintenance and enhancement: Ceramide is broken down in the epidermis by lamellar vesicles that transport glucosylceramide from the granular layer to the stratum corneum. During this process, ATP-binding cassette transporter superfamily A12 (ABCA12) promotes the aggregation of glucosylceramide in lamellar vesicles. ...
Blueberry were recently invited to write two commentaries on the challenges of treating skin and nail diseases and the potential for nanotechnology approaches in dermal drug delivery. Here we share a brief overview of these articles. We will all have encountered someone who is dealing with or has previously experienced a common ailment of the skin or nails, such as eczema (atopic dermatitis), ...
The uppermost layer of the skin, the stratum corneum, protects everything underneath (Marmur, n.d.). Once it dries out or becomes cracked, the protective shield is compromised. ...
The acute phase of AD occurs at the onset of Th1-cell activation.12 Also, Th17 cells play a role in the development of AD, acting as an initial cytokine source for the development of skin lesions.13 In AD patients, transepidermal water loss (TEWL) increases due to defects of the intercellular lipid bilayers in the stratum corneum.14 TSLP-stimulated dendritic ...
The delivery platform called DYV600 (Dyve Biosciences) ushers drugs for therapeutic and aesthetic indications through two key transdermal doors: the stratum corneum lipid matrix and tight junctions, according to data presented from Dyve’s melasma drug candidate’s human proof-of-concept study presented in May at the Aesthetics Innovation Summit 2019. ...
Paradoxically, SC-SNEDDS exhibited scanty transdermal permeation that could be attributed to low water content of stratum corneum. Nanoemulsion and SNEDDS elaborated exhibited promising in-vitro characteristics for oral sildenafil citrate delivery whereas nanoemulsion elaborated was promising for SC transdermal permeation, as well.Keywords: sildenafil citrate, ...