Stress Responsive Articles & Analysis: Older
32 articles found
Ubiquitination is a post-translational modification process that involves various biological processes, including signal transduction, cell cycle regulation, cell stress responses, and cell apoptosis. It plays a crucial role in maintaining protein homeostasis, regulating various biological reactions in cells, and ensuring the normal physiological functions of ...
By cleaving RNA molecules, RNases are integral to numerous biological processes, ranging from RNA maturation to the innate immune response against RNA viruses. In this exploration, we delve into the multifaceted nature of ribonucleases, examining their structure, function, and potential in biotechnology. ...
Phosphorylation Usually occurs on serine or threonine residues, it is a dynamic and reversible modification that affects gene expression, cell cycle, and DNA damage response. 4. Ubiquitination Addition of ubiquitin protein is associated with protein degradation, but ubiquitination on histones can also influence chromatin structure and function. 5. ...
Biological Effects Histone SUMOylation plays a role in regulating stress responses, cell cycle and cell differentiation. Additionally, it is closely associated with the process of DNA damage repair. 4. ...
It is well known that miRNAs are involved in many essential cellular processes, such as cell proliferation, differentiation, apoptosis, stress response and tumorigenesis etc. MiRNAs function in RNA silencing and post-transcriptional regulation of gene expression. ...
Drug Discovery and Development: DGE analysis facilitates the identification of genes responsive to specific drug treatments. By unraveling the molecular mechanisms underpinning drug response, we can optimize treatment strategies, expedite drug discovery, and develop personalized therapies tailored to individual patients. ...
By unraveling the molecular mechanisms underlying drug response, we can optimize treatment strategies, expedite drug discovery, and develop personalized therapies tailored to individual patients. ...
Welcome to our newest blog series where we investigate Amyotrophic Lateral Sclerosis (ALS) using our AI knowledge mapping tools. Check back for our next installment, in which we analyze transcriptomics from spinal cord samples collected from patients as well as a mouse model. In this post, we will continue to explore publicly available datasets surrounding Amyotrophic Lateral Sclerosis ...
ByPercayAI
Since the 19th century, the practice of tissue processing has remained largely unchanged, resulting in solidified, paraffin-embedded tissue blocks for sectioning. As staining procedures have advanced and immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurate interpretation of disease ...
The analysis of intestinal barrier function changes in post-trauma animal models showed that small intestinal DAO activity was negatively correlated with plasma DAO activity, and changes in blood DAO activity reflected intestinal injury, and the changes were correlated with plasma endotoxin levels and bacterial translocation. The stress response produced by ...
Mitochondria have multiple functions, not only providing energy to cells through oxidative phosphorylation to produce ATP, but also involved in regulating processes such as calcium homeostasis, reactive oxygen species (ROS) production, cellular stress response and cell death. Mitochondria play a key role in maintaining cellular health and viability, and their ...
Messenger RNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms responsible for selective and regulated pseudouridylation of specific sequences within mRNAs still remain unknown. ...
"Abstinence from alcohol activates the stress system in the brain, which leads to recurrence, and in this study, we linked this stress response to CSF1 (a neuroimmune mediator), providing new opportunities for therapeutic intervention," said senior author Marissa Roberto, PhD, professor in the Department of Molecular Medicine at the Scripps ...
This is someone whose body is having a massive stress response 24/7.” According to Sapolsky, this stress response is due to, among other things, stress hormones – specifically, a hormone called glucocorticoids, commonly understood as “cortisol”. The stress ...
Discovery of biomarkers Multiple stress responses in microorganisms are accompanied by disordered lipid metabolism. ...
Part II: Understanding familial and sporadic ALS Welcome to our newest blog series where we investigate Amyotrophic Lateral Sclerosis (ALS) using our AI knowledge mapping tools. Check back for our next installment, in which we analyze transcriptomics from spinal cord samples collected from patients as well as a mouse model. In this second post in our Exploring ALS series, we will begin to dig ...
ByPercayAI
Gene enrichment analysis indicated that both nanoparticles mainly enriched ontology groups such as responses to stress (abiotic and biotic), and defense responses (pathogens), and responses to endogenous stimuli (hormones). Nano‐titania specifically induced genes associated with photosynthesis, whereas nano‐ceria induced ...
As a representative species of nematodes, Caenorhabditis elegans is an attractive animal model for evaluating ecotoxicological effects and intrinsic mechanisms of stress response in vivo. To acquire a better knowledge of environmental effects of bisphenol A (BPA), ecotoxicological evaluations were conducted using C. elegans upon the physiological (growth, ...
Comparative genomic analysis of 41 conserved Cr-responsive miRNA families revealed that 11 miRNA families showed up-regulation in Guiyan1 but unaltered in Yunyan2, and 17 miRNA families were up-regulated only in Yunyan2 under Cr stress. ...
The autochthonous toad Rhinella arenarum was selected to study the acute toxicity of As and the biochemical responses elicited by the exposure to As in water during its embryonic development. ...