Targeted Boron Drugs Articles & Analysis
183 articles found
In the bustling city of the cell, proteins are the tireless workers. They build structures, carry messages, and catalyze the chemical reactions essential for life. But a protein's job isn't static. Its function, location, and even its lifespan are tightly controlled by a series of modifications. Among the most versatile and critical of these is Protein Ubiquitination, a process that acts like a ...
The Hidden Language of Glycans Imagine a vast molecular conversation happening within and between cells—where sugar-based structures act as sophisticated messengers carrying critical biological information. These complex carbohydrate structures, known as glycans, represent far more than simple decorative elements on proteins and lipids. They constitute an intricate "glycocode" that ...
In this white paper, Predictive Oncology (POAI) highlights a recent successful project in partnership with the University of Michigan Natural Products Discovery Core (NPDC) through the ACE program. The ACE program supports academic researchers in their early drug discovery and development initiatives by providing access to the POAI proprietary active machine learning platform and ...
In the realm of pharmacology and drug development, the assessment of drug permeability is essential. One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. This assay plays a pivotal role in understanding how drugs are absorbed in the gastrointestinal tract and aids in predicting their bioavailability. Background ...
Nitrogen compounds are a crucial aspect of pharmaceutical chemistry, particularly in the development of antibiotics. Their unique chemical properties, including the ability to form multiple hydrogen bonds and engage in various interactions, make them indispensable in the fight against bacterial infections. This article delves into the application of nitrogen compounds in antibiotic research and ...
Antibody-Drug Conjugates (ADCs) represent a groundbreaking advancement in targeted cancer therapy, combining the specificity of antibodies with the potency of cytotoxic drugs. The development and production of ADCs are complex processes that require a deep understanding of both biology and chemistry, alongside cutting-edge technology. This article delves into the intricacies of ADC development ...
Watertown, MA – March 24, 2025 – Biopharma PEG, a leading supplier of high-quality polyethylene glycol (PEG) derivatives, highlights its innovative product DSPE-PEG-Mannose, an advanced biomedical polymer with significant potential in drug delivery, tumor-targeted therapy, tissue recognition, and adhesion.Structural Advantages of DSPE-PEG-MannoseDSPE-PEG-Mannose is composed of three key ...
Anti-Tumor APIs: Pioneering Cancer Treatment Anti-tumor Active Pharmaceutical Ingredients (APIs) are vital in today's medical landscape, addressing one of the most pressing health challenges: cancer. These APIs form the foundation of various therapeutic strategies aimed at inhibiting or destroying tumor cells in the human body. The classification of anti-tumor APIs often falls into four main ...
Introduction Custom knockout cell lines represent a groundbreaking advancement in molecular biology and genetics, allowing researchers to manipulate genes with precision and study their functions in a controlled environment. By creating cell lines with specific genes “knocked out,” scientists can investigate disease mechanisms, screen drug candidates, and develop gene therapies more ...
In recent years, the rise of drug-resistant cells has emerged as one of the most significant challenges in the field of medicine, particularly in oncology and infectious diseases. The effectiveness of current therapies is often hindered by the ability of certain cell populations to develop resistance, leading to treatment failure and disease progression. This article explores the importance of ...
Compounds of phosphorus play a pivotal role in various fields, notably pharmaceuticals and industrial chemistry. Their unique chemical properties, such as reactivity and ability to form diverse structures, make them invaluable in drug synthesis and other industrial applications. This article delves into the chemical characteristics of phosphorus compounds, their applications in drug development, ...
In the fast-evolving landscape of biotechnology and systems biology, understanding the dynamic processes that sustain life at a cellular level is crucial for advancing research and therapeutic applications. One essential approach to studying cellular metabolism is Metabolic Flux Analysis (MFA), a powerful tool that reveals the intracellular activities and metabolic dynamics of living systems. ...
Nuclear receptors are a class of proteins that play a vital role in cellular communication, gene expression, and overall homeostasis within the body. They act as transcription factors, responding to various stimuli, including hormones, nutrients, and even environmental agents. Due to their crucial roles in physiological and pathological processes, nuclear receptors have emerged as significant ...
In the rapidly evolving field of pharmaceuticals, nanotechnology has emerged as a revolutionary force, transforming the landscape of drug delivery and formulation development. The integration of nanotechnology into pharmaceutical formulation offers unprecedented opportunities to enhance the efficacy, safety, and convenience of therapeutic interventions. This article explores the profound impact ...
What Is PROTAC Technology? Proteolytic targeting chimera (PROTAC) is a new type of drug design technology that works by inducing the degradation of target proteins. Unlike conventional small molecules that typically inhibit protein function, PROTACs facilitate the ubiquitination and subsequent degradation of specific proteins. This bifunctional molecule consists of two distinct elements: a ...
Breast cancer remains one of the most prevalent malignancies affecting women worldwide, necessitating innovative approaches for effective treatment and research. Among the most promising strategies in this endeavor are the use of tumor models for breast cancer and the development of customized antibody-drug conjugates (ADCs). These advancements not only enhance our understanding of the disease ...
Introduction Microarray printing technology has revolutionized the field of genomics and proteomics, and its application in glycobiology is no exception. Glycobiology, the study of carbohydrates and their biological functions, relies heavily on the ability to analyze large-scale carbohydrate interactions. Microarray printing in glycobiology enables the precise and high-throughput analysis of ...
Reporter stable cell lines are invaluable tools in molecular biology and biochemistry. By integrating a reporter gene into the genome of a cell, researchers can create a stable cell line that emits a measurable signal in response to specific stimuli or conditions. This technology has revolutionized various fields, including drug discovery, gene expression studies, and cellular signaling research. ...
Alfa Cytology has introduced its advanced drug development services for brain tumors. Alfa Cytology, celebrated for its cutting-edge biotech solutions and extensive tumor research expertise, has recently introduced brain tumor drug development services, designed to empower researchers in understanding the intricacies and unique challenges associated with brain tumors. Brain tumors represent a ...
Liposomes, spherical vesicles composed of one or more phospholipid bilayers, have garnered significant attention in the field of drug delivery due to their unique properties. These nanocarriers offer a promising approach to overcome challenges associated with traditional drug administration, enhancing therapeutic efficacy while minimizing side effects. This article will delve into the role of ...