therapeutic development Articles
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Navigating Cancer Announces New Appointment to Board of Directors
Navigating Cancer announced today that Alexandra Snyder, MD, Chief Medical Officer at Generate Biomedicines, has agreed to join its board of directors. Dr. Snyder is succeeding David M. Rubin, Ph.D. who served on Navigating Cancer’s Board from 2015 to the present. “We are pleased to welcome Dr. Snyder to Navigating Cancer’s Board and especially value her point of view as a ...
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Impact of the life sciences on organisation and management of R&D in large pharmaceutical firms
The life sciences are having a significant impact on the organisation and management of R&D in large pharmaceutical firms, as well as restructuring the markets for new therapeutic products. However, there is continuing scepticism about large firms' ability or inclination to build in-house capacity for biologics and extract value from the life sciences. This paper explores the effect of life ...
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The Structure of Key Proteins in Parkinson`s Disease Solved
Australian researchers have recently solved a multi-year mystery about Parkinson's disease. They solved the structure of a key protein that is expected to rapidly treat this incurable disease. The findings appear in Nature. For the first time, the researchers took a "live" shot of a protein called PINK1. The findings explain how this protein is activated in cells, thereby initiating the ...
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Accelerating stem cell knowledge into regenerative medicine by OUH-CELL-BENCH
One major challenge for implementing stem cell treatment in the clinics, is the interdisciplinary work required by stem cell biologists and medical doctors as well as the state-of-the-art equipment needed at public hospitals to successfully translate the basic stem cell knowledge into clinical products. Our facility directly serves to speed up the development cell therapeutics, by establishing an ...
By Baker
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Recent developments in therapeutic applications of atomic and nuclear radiations
In recent years, the major 'challenge' of radiation treatment is to deliver large enough doses to the most resistant cancer cells to provide a high probability of local control while minimising the dose to normal tissues and hence reducing complications. With recent developments in 'imaging' the metabolic or functional status of cancers, the position of tumours relative to surrounding normal ...
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Advanced Approaches in Inducible Expression Stable Cell Line Development
Harnessing the power of cell biology, scientists across the globe are perpetually invested in the pursuit of understanding the complexities of cellular mechanisms and their adaptability. One such venture is the creation of Inducible Expression Stable Cell Line (IESCL) development. IESCL signifies a consolidated methodology designed to explore the potentialities of modulated gene expression. This ...
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Utilizing Zebrafish Genome Editing Services: Shaping the Future of Genomic Research
Within the rapidly advancing realm of biotechnology, zebrafish genome editing services are carving a niche, heralding a new epoch in genomics and cellular research. This development is driving innovative research approaches, empowering researchers to create effective models to comprehend complex genetic interactions and responses quickly and efficiently. Zebrafish, also known as Danio rerio, ...
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Chronic cadmium exposure promotes nasopharyngeal carcinoma
Chronic cadmium exposure promotes nasopharyngeal carcinoma progression and radioresistance Dr Lin Peng and her team investigate how environmental pollutant exposure influences the risk of cancer development and therapeutic resistance at the Department of Laboratory Medicine, Cancer Hospital of Shantou University Medical College, ...
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An Overview of Mainstream Carbohydrates in the Market
As one of the primary biomolecules in nature, carbohydrates are critical elements in nutrition provision, energy transportation, cell composition, etc. In view of their universality and essentiality in research, this article is an exploration of carbohydrates, especially those hot ones in the market. Chemical Classifications of Carbohydrates There are different ways to classify carbohydrates, ...
By BOC Sciences
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Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines
From the eradication of smallpox through to the global response to the COVID-19 pandemic, vaccines have been a cornerstone in the fight against infectious diseases in humans and livestock since the 18th century. Although vaccines against COVID-19 are unlikely to eradicate the disease in the way that the smallpox vaccine did, they have proved very effective in preventing death and hospitalisation, ...
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Cytokines: Characteristics, Applications, and Quantitative Analysis
Cytokines represent a class of small protein molecules that exhibit diverse biological activities. These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cells, epidermal cells, and fibroblasts) upon specific stimulation. Cytokines play pivotal roles in ...
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Rani Therapeutics prices $73M IPO for robotic drug-delivery pill tech
Rani Therapeutics Holdings (NSDQ:RANI), developer of a robotic drug-delivery pill system, generated $73.3 million in its underwritten initial public offering (IPO) of Class A common stock. The San Jose, Calif.–based company’s IPO of 6.7 million shares priced at $11 a share, generating gross proceeds of $73.3 million. The company initially targeted an IPO worth approximately $100 ...
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Epitope Specific Case Study
Published example: Computationally designed epitope specific Multibody binding a cryptic epitope Challenge: Designing an Ab for a cryptic epitope - not exposed to solvent in the native conformation* N terminus covers epitope in the native conformation and desired binding site (epitope) is hidden Biolojic’s solution - epitope specific Antibody which moves the N terminus and ...
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Maimonides Institute for Biomedical Research of Cordoba (IMIBIC) - Case Study
Name: Eduardo Chicano-Galvez Job Title: Head of Proteomics Unit Company: Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain Eduardo Chicano-Galvez, Head of Proteomics, IMIBIC Peak provides nitrogen for Proteomics Eduardo Chicano-Galvez and his team at Maimonides Institute for Biomedical Research of Cordoba (IMIBIC) use a Peak Infinity 1032 compressor-less ...
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Drug Discovery: Unraveling the Mysteries of Therapeutic Agents
In the vast and ever-evolving field of medicine, the discovery of new drugs has been a critical pursuit, offering hope and relief to countless individuals suffering from various ailments. The process of drug discovery is a complex and multifaceted endeavor, involving the integration of diverse scientific disciplines, including biology, chemistry, and computational science. At the heart of this ...
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Bioprocess Automation, Remote Monitoring, and Real-Time Data Capture Underpin Operation Warp Speed’s Push for a COVID-19 Vaccine
Life science companies spanning the globe are striving to quickly develop and commercialize COVID-19 therapeutics and grab the brass ring of a viable, effective, and safe SARS-CoV-2 vaccine. In the United States, pharmaceutical and biotech companies, as well as Contract Development and Manufacturing Organizations (CDMOs), from coast-to-coast are racing to complete clinical trials and forge ...
By Lab Owl
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Researchers Prepared New Tools for the Production of Exosome Drug Carriers
Recently, Yang Hui, a researcher at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, developed a nanofluidic chip technology to achieve high-throughput preparation of exosome drug carriers and experimentally verify the anti-tumor effect of novel exosome drug carriers. Exosomes are nanoscale particles that can be secreted into the extracellular space or body fluids by ...
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The Development Process of DUBTAC
The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered “undruggable”, and several projects have entered clinical evaluation worldwide. Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer. ...
By BOC Sciences
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Exploring Advanced Industrial Development Services for Probiotics
In the realm of modern health and wellness, the symbiotic relationship between humans and their gut microbiota has taken center stage. Probiotics, or "friendly bacteria," have garnered immense interest for their potential to influence various physiological processes, from digestive health to immune modulation. The expedition of harnessing the therapeutic potential of probiotics is intricately ...
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Unveiling the Role of CDH1 Protein in Cancer and Future Research Directions
Introduction CDH1, also known as E-cadherin, is a crucial protein involved in cell adhesion and plays a significant role in various biological processes. In recent years, researchers have focused on understanding the functions of CDH1 and its implications in cancer development. This blog post aims to shed light on what CDH1 protein does, its role in cancer, and the future research directions in ...
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