therapeutic potential Articles
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Functional interactions between cannabinoids, omega-3 fatty acids, and peroxisome proliferator-activated receptors: Implications for mental health pharmacotherapies
Abstract Cannabis contains a plethora of phytochemical constituents with diverse neurobiological effects. Cannabidiol (CBD) is the main non-psychotropic component found in cannabis that is capable of modulating mesocorticolimbic DA transmission and may possess therapeutic potential for several neuropsychiatric disorders. Emerging evidence also suggests that, similar to CBD, omega-3 ...
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Prominent Names in RNA Delivery Discuss What’s Around the Corner
Oxford Global kicked off another exciting discussion group all about RNA therapeutics and emerging technologies for their delivery. Those attending were experts from the leading authorities in the field. Leading the conversation was Susan Rosenbaum, Founder, Chairman, and CEO of Lauren Sciences, a company that has been the recipient of twelve foundation grant awards and won first prize for Global ...
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Brain–Computer Interface for Motor Recovery
Click here for full article " Contralesional Brain–Computer Interface Control of a Powered Robotic Hand-Piece for Motor Recovery in Chronic Stroke Survivors" on AHA Journals - Stroke Abstract Background and Purpose— There are few effective therapies to achieve functional recovery from motor-related disabilities affecting the upper limb after stroke. This feasibility study tested ...
By Neurolutions
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The Potential of WNT/B-Catenin Modulation in Treating Pulmonary Fibrosis
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options. While WNT/β-catenin signaling plays a crucial role in lung development and maintenance of adult lung stem cells, its dysregulation has been associated with pulmonary fibrosis. However, recent ...
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A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia (Clinical Cancer Research)
Purpose:Although considerable progress has been made withautologous T cell–based therapy in B-cell malignancies, appli-cation in chronic lymphocytic leukemia (CLL) lags behind dueto disappointing response rates as well as substantial toxicitythat is of particular concern in the elderly CLL population.Vg9Vd2-T cells form a conserved T-cell subset with strongintrinsic immunotherapeutic ...
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Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
Abstract Natural killer (NK) cells hold promise for improving the therapeutic potential of allogeneic hematopoietic transplantation, but their effectiveness is limited by inhibitory HLA types. We sought to overcome this intrinsic resistance by transducing CD56+CD3- NK cells with chimeric receptors directed against CD19, a molecule widely expressed by malignant B cells. An abundance of NK ...
By Nkarta, Inc.
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The Role of MMP-3: Insights into Disease Progression and Therapeutic Potential
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular ...
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Nebulised MSC-Derived EVs: A Potential Therapy for E. coli-Induced Pneumonia
Mesenchymal stem cells (MSCs) have shown great promise in cell therapy for various diseases, including lung injury. However, recent research has focused on the therapeutic potential of extracellular vesicles (EVs) derived from MSCs. These EVs contain bioactive molecules that can modulate immune responses and promote tissue repair. In the context of pneumonia caused by Escherichia coli (E. coli) ...
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RNA-targeted Gene Therapy
In recent years, various nucleic acid-based therapies (NBT) have emerged as effective and specific activators of endogenous gene expression. Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and ...
By BOC Sciences
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Unveiling The Manifold Potentials: Mesenchymal Stem Cells & Bone Marrow Mesenchymal Stem Cells
In the vibrant realm of cellular biology and regenerative medicine, mesenchymal stem cells (MSCs) hold unparalleled potential for therapeutic applications. Particularly noteworthy are bone marrow mesenchymal stem cells (BM-MSCs), a subtype of MSCs. Their unique properties make them indispensable resources for developing ground-breaking solutions for various medical conditions. Mesenchymal stem ...
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The correlation of hypersensitivity for HRS/IRR and the 'inverse' dose-rate effect – its potential influence on LDR brachytherapy: a review
The 'Inverse' Dose-Rate Effect (IDRE) has been extensively studied (Leonard, 2000; 2007a; Leonard and Lucas, 2008a?b). We here consolidate these results. We have shown a correlation between Hyper-radiosensitivity and the Induced Radioresistance effect (HRS/IRR), and IDRE has the same threshold and transition behaviours. This supports a conclusion that IDRE is the dose-rate manifestation of ...
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Rani Therapeutics prices $73M IPO for robotic drug-delivery pill tech
Rani Therapeutics Holdings (NSDQ:RANI), developer of a robotic drug-delivery pill system, generated $73.3 million in its underwritten initial public offering (IPO) of Class A common stock. The San Jose, Calif.–based company’s IPO of 6.7 million shares priced at $11 a share, generating gross proceeds of $73.3 million. The company initially targeted an IPO worth approximately $100 ...
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Nanotechnology as a basis for the vascular treatment of atherosclerosis
It is now accepted that during the early stages of development of coronary and carotid atherosclerotic plaques, activation of vasa vasorum (VV) at specific sites in the adventitia initiates their proliferation or 'angiogenesis', and migration through the media into the intima of unstable developing lesions. Plaques regions containing these immature vessels tend to exhibit increased inflammation ...
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Reactive oxygen species regulate hypoxia-inducible factor 1 differentially in cancer and ischemia
In exercise, as well as cancer and ischemia, hypoxia-inducible factor 1 (HIF1) transcriptionally activates hundreds of genes vital for cell homeostasis and angiogenesis. While potentially beneficial in ischemia, upregulation of the HIF1 transcription factor has been linked to inflammation, poor prognosis in many cancers, and decreased susceptibility of tumors to radiotherapy and chemotherapy. ...
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Reactive oxygen species regulate hypoxia-inducible factor 1 differentially in cancer and ischemia
In exercise, as well as cancer and ischemia, hypoxia-inducible factor 1 (HIF1) transcriptionally activates hundreds of genes vital for cell homeostasis and angiogenesis. While potentially beneficial in ischemia, upregulation of the HIF1 transcription factor has been linked to inflammation, poor prognosis in many cancers, and decreased susceptibility of tumors to radiotherapy and chemotherapy. ...
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Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants
Abstract Detailed IgE-binding epitope analysis is a key requirement for the understanding and development of diagnostic and therapeutic agents to address food allergies. An IgE-specific linear peptide microarray with random phage peptide display for the high-resolution mapping of IgE-binding epitopes of the major soybean allergen Gly m 4, which is a homologue to the birch pollen allergen Bet v ...
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How to Prepare Nano-vesicles for Encapsulating Protein Drugs?
Nano-vesicles, also known as liposomes, have emerged as promising drug delivery systems due to their unique structure and properties. These tiny spherical lipid bilayers can encapsulate various therapeutic agents, including protein drugs. In this article, we will explore the process of preparing nano-vesicles for encapsulating protein drugs, as well as the advantages of utilizing this innovative ...
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MicroRNA-155 is regulated by the transforming growth factor β/smad pathway and contributes to epithelial cell plasticity by targeting RhoA
Transforming growth factor β (TGF-β) signaling facilitates metastasis in advanced malignancy. While a number of protein-encoding genes are known to be involved in this process, information on the role of microRNAs (miRNAs) in TGF-β-induced cell migration and invasion is still limited. By hybridizing a 515-miRNA oligonucleotide-based microarray library, a total of 28 miRNAs were ...
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Virtual Screening: Revolutionizing Drug Discovery through Computational Intelligence
In the fast-paced realm of drug discovery, scientists constantly seek innovative approaches to efficiently and cost-effectively identify potential drug candidates. Virtual screening, a breakthrough computational technique, is poised to transform the pharmaceutical industry. In this article, we delve into the world of virtual screening and explore its remarkable potential to revolutionize drug ...
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Single Guide RNA Libraries: Their Applications and Future Potential in Biotechnology
The phenomenal advancements in the realm of biotechnology have propelled the development of tools with remarkable potential, considerably altering the landscape of biological and medical research. One such groundbreaking tool topping the list among modern biotechnologies is the Single Guide RNA (sgRNA) library. This article will delve into the present and future applications of this revolutionary ...
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