tissue cells Articles
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Multiomics sequencing goes spatial
Microfluidic channels provide a means to deliver barcodes encoding spatial information to a tissue, which allows co-profiling of gene expression and proteins of interest in a spatially resolved manner. Back in 2013, Rong Fan from Yale University was intrigued by a conversation with colleague Kathryn Miller-Jensen: they noticed that trypsinizing cancer cells off the substrate could perturb the ...
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Induction of adipose tissue regeneration by chemically-modified hyaluronic acid
Hyaluronan was modified by amidation of the carboxyl groups with dodycyl amides to produce a viscous gel (HYADD3). Small aliquots were implanted intramuscularly in Wistar rats at a concentration of 30 mg/ml for up to 12 weeks. Standard histology and immunohistochemistry demonstrated low levels of inflammation at all time periods, absence of any fibrous capsule coupled with the presence of mature ...
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What is Nano Dressing?
Nanotechnology has not only received attention and applications in the field of drug delivery, but also has achieved many successes in the field of tissue engineering. Nano dressings can be defined as dressings in which nanomaterials are the matrix. The birth of nano dressings has brought new treatment methods for wound repair and burn care, such as nanohydrogels, nanofibers, nanomembranes, ...
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Nanoparticle Development: Revolutionizing Drug Delivery Systems
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific ...
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The University of Chicago - Case Study
The research goals of Carole Ober’s laboratory at the University of Chicago are to identify genetic variants that influence gene expression and epigenetic patterns in tissues relevant to complex phenotypes, especially related to asthma and fertility. The lab uses both freshly isolated cells, as well as tissue and cell culture models of gene-environment interactions to explore ...
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Sterility Assurance Applied to Stem Cell Therapies
Abstract Stem cell therapies are becoming more important in the pharmaceutical industry. The genetic manipulations of the cells involved create a powerful tool to treat serious diseases, such as cancer. In 2017, the Food and Drug Administration (FDA) made several advancements towards regulation of stem cell therapy: Published perspective on stem cell therapy in the New England Journal of ...
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Significance of Diagnostic Enzyme Detection
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Application of Enzyme Detection in Clinical Diagnosis
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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The development of radiobiology in Bulgaria
The ongoing changes in radiation risk assessment and development of ICRP conceptions is greatly due to the achievements of radiobiology. At doses below 0.2 Sv, radiation risk is determined only by stochastic effects. In these cases initial changes at molecular and cellular level and potentially lethal damage cannot be detected with known methods. Radiobiology and molecular epidemiology will ...
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Reinventing the pig: the negotiation of risks and rights in the USA xenotransplantation debate
Xenotransplantation (XTP) involves the transplantation of cells, tissues and organs from non-human mammals (usually pigs) to humans. Because XTP could produce considerable public health gains, advocates want to proceed to human clinical trials as soon as possible. However, XTP also raises complex regulatory issues, since virtually all scientists agree that there is a risk of pig endogenous ...
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Nanoparticulate systems for oral drug delivery to the colon
A review of oral drug delivery to the colon is a difficult but desirable method of administration. In order to target the colon the dosage form must overcome the barriers presented by the gastrointestinal tract including the steep pH gradient, binding to the mucus layer, premature clearance, and premature cellular uptake. Nanoparticles have been fabricated via a number of methods and designed ...
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DNA nanoparticles for gene delivery to cells and tissue
The development over the past decade of methods for delivering genes to mammalian cells has stimulated great interest in the possibility of treating human disease by gene-based therapies. The major aim of gene therapy is to effectively deliver the genetic materials into cells, genetically modifying and repairing cell functions, which may induce therapeutic healing of disease conditions. This ...
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Maintaining Quality in Stem Cell Products: ATMPs and Regulation (Series Part 2 of 4)
What are ATMPs? Stem cells are categorized as Advanced Therapy Medicinal Products (ATMPs) when undergoing substantial manipulation or when used for a different essential function. ATMPs are medicines for human use with gene, tissue or cell components. They can be classified into gene therapy medicines, somatic-cell therapy medicines, and tissue-engineered medicines, depending on how the medicine ...
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Conditioning Media to Target Dissolved Oxygen Levels
Summary Hypoxia is defined as oxygen deficiency in cellular environments. Oxygen (O2) deficiency within in vivo environments is commonly linked to a wide range of co-morbidities, e.g., respiratory failure, Mycobacterium tuberculosis infection and other life threatening ailments (Reference Section; 2, 6). However, certain cell types thrive in low-O2 environments. Angiogenesis and tumor progression ...
By Baker
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Food Sources and Effects of Carotenoids
Carotenoid structure and category The major carotenoids contain α-carotene, β-carotene, γ-carotene, lutein, zeaxanthin, β-cryptoxanthin, lycopene, etc. Among the three isomers of carotenoids, β-carotene has the highest content and γ-carotene the least. α, β, γ-carotene and β-cryptoxanthin can be decomposed to form vitamin A, while lutein, ...
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Long-term performance of implanted bioprinted human liver tissue in a mouse model of human alpha-1 antitrypsin deficiency
Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the clinical success of these promising approaches and has ...
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CD Biosciences Launches Substrate-Chromogens for Immunohistochemistry
CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the launch of its innovative line of Chromogenic Substrates for immunohistochemistry (IHC). These cutting-edge substrates offer superior signal sensitivity, long-term storage stability, enhanced safety, and user-friendliness, empowering researchers to unlock deeper insights into ...
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Regenerative medicine: new opportunities for developing countries
There has been a major shift in burden of disease in developing countries. Although traditionally associated with industrialised nations, epidemic levels of non-communicable diseases, such as diabetes, cardiovascular diseases and cancer, now threaten the developing world and are straining health systems that are still struggling with persisting levels of infectious disease. Developing countries ...
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CD Genomics Perspective: RNA Sequencing, A Powerful Method for Studying Various Diseases
Although post-mortem brains have been frequently reported as the "gold standard" in transcriptomic research for ND and neuropsychiatric abnormalities, the main sources has been mRNA separated from transgenic animal models and, more lately, patient-derived cell lines. However, despite their promise, transcriptome studies are difficult due to the obvious difficulties in obtaining brain tissue and ...
By CD Genomics
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Dissolved Hydrogen Application
Hydrogen molecule is the smallest molecule in nature. It is extremely penetrating and extremely volatile. It can freely enter and exit the body cells, remove aging and toxic free radicals. After drinking, it enters human body tissues and diffuses to act on all organ line particles and nucleus. Absorbed by the body. Realize the balance of the environment in the body and initiate the mechanism of ...
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