tissue engineered Articles
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Nanotechnology in biomedical applications: a review
Incorporation of functionalised and modified nanostructures in various biomedical applications has generated considerable research interest in recent years. The applications of nanotechnology in medicine and biomedical engineering are vast and spans areas such as implant and tissue engineering, diagnosis and therapy. The present scenario demands designing of nanotools which can respond to the ...
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Electrospun nanofibres of polycaprolactone, and their use for tendon regeneration
Inferior scar tissue formed when injured tendons heal often results in ongoing pain and site morbidity. With current treatments being ineffective, there is a clinical need for a tissue engineered approach. Electrospinning produces nanofibres with morphologies and architectures similar to the natural extra cellular matrix. Research incorporating electrospinning for tendon regeneration is limited. ...
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Hydrothermal synthesis of coccolith rich chalk to hydroxyapatite
Calcium carbonates originating from marine sources show unique pore structure and nano–architecture, offering potential in the field of hard tissue engineering. It is hypothesised that the use of naturally–sourced raw materials for the synthesis of hydroxyapatite (HA), as a component of a hard tissue constructs, enables enhanced bone remodelling due to the biomimetic physical–chemical ...
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Science Bake Off - Engineers Use Soda Bread In Tissue Engineering
Summary Scientists were not immune to the home baking trends that grew out of a year of self-isolation and working from home. A creative application of soda bread as scaffolding for tissue engineering produced some exciting results and highlights the value of keeping it ...
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Microneedle Preparation Technologies
Introduction Microneedles have gained significant attention in recent years due to their potential applications in various fields such as drug delivery, diagnostics, and tissue engineering. The preparation of microneedles requires precise and efficient technologies to achieve desired features such as size, shape, and mechanical strength. This article provides an overview of different ...
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Growth and behaviour of bovine articular chondrocytes on nanoengineered surfaces: Part I
Surface modification, using biomaterials to mimic in vivo cell microenvironment, plays an important role in tissue engineering. Current work studies the growth and behaviour of primary bovine articular chondrocytes on layer-by-layer self-assembled nanofilms of 11 different biomaterials, including polyelectrolytes and proteins [poly(styrene sulphonate) (PSS), fibronectin, poly-L-lysine (PLL), ...
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Bioactive compounds obtained by immobilisation of serine protease inhibitors
We studied the preparation of polymeric membranes formed of solutions of poly–3–hydroxybutyrate (PHB) and chitosan. PHB–chitosan biomaterials from these solutions may form various structural types, which determine the biodegradation time, the adsorption capacity, and the kinetics of the release of medicinal compounds from polymeric matrices. Serine protease inhibitors, SERPINs, continue to catch ...
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Uses of Recombinant Human Collagen
Collagen is the main structural protein in vertebrates. It plays an essential role in providing a scaffold for cellular support and thereby affecting cell attachment, migration, proliferation, differentiation, and survival. Natural animal collagen and its recombinant collagen are favorable replacements in human tissue engineering due to their remarkable biomedical property. However, this ...
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Regenerative medicine: new opportunities for developing countries
There has been a major shift in burden of disease in developing countries. Although traditionally associated with industrialised nations, epidemic levels of non-communicable diseases, such as diabetes, cardiovascular diseases and cancer, now threaten the developing world and are straining health systems that are still struggling with persisting levels of infectious disease. Developing countries ...
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Introducing CellQART Cell Culture Inserts: Giving New Life to Tissue Engineering
The new line of cellQART cell culture inserts, offered by Sterlitech, have important applications in medical science. Cell culture inserts have been used widely in tissue engineering because they allow access to both sides of the membrane. Each insert is designed to fit inside the well of a culture plate, making it more effective for growing 3D tissue layers than seeding cells directly on the ...
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An Early Study on the Mechanisms that Allow Tissue-Engineered Vascular Grafts to Resist Intimal Hyperplasia
Abstract : Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the study. Intimal hyperplasia in the outflow vein of TEVGs was assessed at ...
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Health-related biotechnology in Brazil - some regulatory and ethical considerations
The main purpose of this article is to present an overview of the complex regulatory and ethical challenges associated with the expansion of health-related biotechnology in Brazil. Initially, the author presents the general characteristics of Brazil, a developing Latin American country. The general panorama of human health-related biotechnology in the country is addressed. Finally, the author ...
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Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease
Abstract Objective: Vascular conduit is essential for arterial reconstruction for a number of conditions, including trauma and atherosclerotic occlusive disease. We have developed a tissue-engineered human acellular vessel (HAV) that can be manufactured, stored on site at hospitals, and be immediately available for arterial vascular reconstruction. Although the HAV is acellular when implanted, ...
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History Development of Hydrogels
Hydrogels are composed of hydrophilic polymers, whose three-dimensional network structure can not only absorb a large amount of water, but also be used to carry drugs. Hydrogels prepared with suitable materials have the characteristics of high biocompatibility, mechanical and viscoelastic control. Since the term was coined in the late 19th century, hydrogels have been widely used in drug ...
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Electrospinning Technology of Recombinant Human Collagen
Electrospinning can produce continuous fibers on the micro - and nano-scale. The high flexibility and low cost of the material make electrospinning very attractive. In addition, the high specific surface area, porosity, and similarity to ECM ensure that the electrostatic pad promotes cell adhesion, skin regeneration, nutrient and oxygen transport, moisture retention, exudate removal, and ...
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Bioprinting Algae To Improve Tissue Oxygenation
Engineers often rely on Mother Nature to help solve difficult problems. After millions of years of evolution, living organisms such as plants, animals, and microbes have discovered how to survive in even the harshest of environments. Often times, organisms from different species are able to provide each other with the nutrients, resources, or protection that both need to prosper. We call ...
By Allevi, Inc.
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UCT Silane Cited in Organ-On-Chip
The ventricular myocardium of the human heart is composed of an anisotropic tissue structure that allows for force generation and contraction to pump blood throughout the body. It has long been established that the collagen-rich, fibrous, extracellular matrix environment guides the formation of this laminar tissue architecture. The structural and mechanical properties of the cardiac ...
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Effect of endothelium mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial cells and smooth muscle cells
Abstract The goal of this study is to develop unique native endothelium mimicking nanomatrices and evaluate their effects on adhesion and spreading of human umbilical vein endothelial cells (HUVECs) and aortic smooth muscle cells (AoSMCs). These nanomatrices were developed by self-assembly of peptide amphiphiles (PAs) through a solvent evaporation technique. Three PAs, one containing the ...
By Endomimetics
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What Are Heparins?
Heparin, also known as standard heparin or unfractionated heparin, is a linear polysaccharide consisting of 1-4 linked disaccharide repeat units of uronic acid and glucosamine residues. Heparin was discovered nearly 100 years ago and has been used clinically as a blood anticoagulant since 1935. This is due to its ability to bind to the antithrombin(serine protease inhibitor), causing the ...
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Bio Is the New Techonomy
I’ve spent years as a biotech cheerleader, trumpeting the idea that biology can power innovation across diverse industries. Lately, I’m getting the feeling that experts in lots of other fields are also taking up the cheer. Case in point: Techonomy, the annual conference in Palo Alto that explores how technology is integral to the economy in which we live. At this spring’s ...
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