tissue remodeling Articles
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Silk Fibroin Enhances Tendon Repair and Tissue Regeneration
Researchers at the Terasaki Institute for Biomedical Innovation have used silk protein, which is produced by silkworms, as a biomaterial for tendon repair. The researchers report that their approach has made significant progress in tendon regeneration of mesenchymal stem cells (MSCs). SF is a promising biomaterial for tendon repair, but its relatively rigid mechanical properties and low cell ...
By Matexcel
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Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis
Publication Summary: Compound induced chronic liver injury can lead to initiation of profibrotic processes resulting in sustained production of growth factors and profibrotic cytokines where inflammation, tissue remodeling and repair pathways are activated simultaneously to counteract the injury. Evaluation of potential antifibrotic therapies are limited using conventional non-human animal ...
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New Cell Contenders in the CAR Field (Part 2)
Why do we need new cell contenders in the CAR field? Well, different CAR immune cells have different advantages and sometimes unique challenges or limitations. So, we began our discussion of alternative CAR-cell types with CAR-NK cells due to their current standing as the most popular alternative CAR-based therapy. However, the expansion of CARs to other cell types has already begun and ...
By Indee Labs
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Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
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What is Nano Dressing?
Nanotechnology has not only received attention and applications in the field of drug delivery, but also has achieved many successes in the field of tissue engineering. Nano dressings can be defined as dressings in which nanomaterials are the matrix. The birth of nano dressings has brought new treatment methods for wound repair and burn care, such as nanohydrogels, nanofibers, nanomembranes, ...
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Introduction to Lipogenesis, Lipid Anabolism and Catabolism
Sources of Fat Fat, also known as triglyceride, is made by condensing one molecule of glycerol and three fatty acids. The source of fatty acids in the body: one is the body's own synthesis, and the other is the food supply. Some unsaturated fatty acids cannot be synthesized by the body and depend on food supply, called essential fatty acids. There are mainly two kinds, one is the ω-3 series ...
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Discovery of Bispecific Antibodies and Immune Checkpoint Inhibitors That Kill Glioblastoma Cells and Melanoma Cells, and Block the Metastasis of Malignant Melanoma Cells to the Lung by Over 90%
Ocean Biomedical will be a wholly owned subsidiary of Aesther Healthcare Acquisition Corp. and will change its name to Ocean Biomedical, Inc., expected to be listed on NASDAQ under the symbol, “OCEA”. PROVIDENCE, R.I. and NEW YORK, Sept. 06, 2022 (GLOBE NEWSWIRE) -- Ocean Biomedical and Aesther Healthcare Acquisition Corp. (“Aesther”) (NASDAQ: AEHA) ...
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Hydrothermal synthesis of coccolith rich chalk to hydroxyapatite
Calcium carbonates originating from marine sources show unique pore structure and nano–architecture, offering potential in the field of hard tissue engineering. It is hypothesised that the use of naturally–sourced raw materials for the synthesis of hydroxyapatite (HA), as a component of a hard tissue constructs, enables enhanced bone remodelling due to the biomimetic physical–chemical ...
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Prolotherapy and the Use of Sugars in Orthopedics
Prolotherapy has been a part of modern orthopedic practices since the 1940s. It is growing in popularity not just in the U.S., but globally as well. Also known as “regenerative injection therapy” (RIT), prolotherapy is a procedure used to treat musculoskeletal conditions including tendinopathies, osteoarthritis, and chronic pain of the cervical spine, lumbar spine, and pelvis (Sit et ...
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Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease
Abstract Objective: Vascular conduit is essential for arterial reconstruction for a number of conditions, including trauma and atherosclerotic occlusive disease. We have developed a tissue-engineered human acellular vessel (HAV) that can be manufactured, stored on site at hospitals, and be immediately available for arterial vascular reconstruction. Although the HAV is acellular when implanted, ...
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Regenerating Tissue with NovoSorb BTM
Unlike the body’s reparative healing response for deep wounds, which is chaotic, NovoSorb® BTM is unique in its ability to reorient the healing process from repair into regeneration. NovoSorb BTM is designed to promote the organized generation of a robust vascularized neodermis, designed to minimize scarring and contracture, thus improving functional and cosmetic patient outcomes. ...
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