tissue sample Articles
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Organochlorine pesticides, lead, and mercury in northern bobwhite (Colinus virginianus) and scaled quail (Callipepla squamata) from the Rolling Plains ecoregion of Texas and Oklahoma
Northern bobwhite (Colinus virginianus) and scaled quail (Callipepla squamata) from the Rolling Plains ecoregion in Texas/Oklahoma were evaluated for organochlorine pesticides (OCs), Pb, and Hg. Of all OCs analyzed, only p,p'‐DDE and p,p'‐DDD were found in a few composite liver samples. Similarly, a small fraction of tissue samples had detectable levels of Hg (liver and breast) or Pb exceeding ...
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Spatial multi-omics sequencing for fixed tissue via DBiT-seq
Highlights Simultaneous transcriptomic and proteomic analysis on fixed tissue slides 10- and 25-μm spot size for varying resolution and near-single-cell analysis DBiT-seq can be conducted with common laboratory equipment and reagents DBiT-seq produces high-quality RNA sequencing data with high spatial resolution (10 μm) Summary This protocol describes the use of the ...
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Uptake and metabolism of individual PBDE congeners by embryonic zebrafish
Embryonic zebrafish were used to compare the uptake and metabolism for six polybrominated diphenyl ether (PBDE) congeners (BDE 28, 47, 99, 100, 153, and 183) and identified metabolites from static exposures at 24 and 120 hours post fertilization. An inverse relationship was observed between PBDE uptake and their octanol‐water partitioning coefficient (uptake of BDE 28 and 47 > 99 and 100 > 153 ...
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Segmentation of the Main Structures in Hematoxylin and Eosin Images
Pathologists conduct a biopsy on a tissue when a carcinoma case for a patient is suspected. They stain the cells on that tissue using some biochemical materials that react with a certain cell element. They put stained cells onto a slide and examine the cells by using an optical microscope device. In our case, we will focus on H&E stained breast tissue samples. Pathologists keep track of a ...
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Generating a robust prediction model for stage I lung adenocarcinoma recurrence after surgical resection
Abstract Lung cancer mortality remains high even after successful resection. Adjuvant treatment benefits stage II and III patients, but not stage I patients, and most studies fail to predict recurrence in stage I patients. Our study included 211 lung adenocarcinoma patients (stages I–IIIA; 81% stage I) who received curative resections at Taipei Veterans General Hospital between January ...
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INOVIQ study validates the use of SubB2M as an aid in diagnosing malignant melanoma
Data from 144 tissue samples in the feasibility study demonstrated that SubB2M immunohistochemistry detected melanoma with 91% sensitivity and discriminated between malignant melanoma and benign skin lesions. SubB2M-based immunohistochemistry applications represent a new product opportunity for SubB2M in the $1.9b immunohistochemistry market. INOVIQ Ltd (ASX:IIQ) has successfully completed ...
By INOVIQ Ltd
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Map of the Month - April
Welcome to Edinburgh Instruments newest blog celebrating our work in Raman, Photoluminescence, and Fluorescence Lifetime Imaging. Every month we will highlight our pick for Map of the Month to show how our spectrometers can be used to reveal all the hidden secrets in your samples. April Studying animal tissue is an important tool for scientists to learn more about the effects of treatments for ...
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A Raman-based endoscopic strategy for multiplexed molecular imaging
Endoscopic imaging is an invaluable diagnostic tool allowing minimally invasive access to tissues deep within the body. It has played a key role in screening colon cancer and is credited with preventing deaths through the detection and removal of precancerous polyps. However, conventional white-light endoscopy offers physicians structural information without the biochemical information that would ...
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Exploring ALS with AI Part II: Understanding familial and sporadic ALS
Part II: Understanding familial and sporadic ALS Welcome to our newest blog series where we investigate Amyotrophic Lateral Sclerosis (ALS) using our AI knowledge mapping tools. Check back for our next installment, in which we analyze transcriptomics from spinal cord samples collected from patients as well as a mouse model. In this second post in our Exploring ALS series, we will begin to dig ...
By PercayAI
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Mercury Contamination in Turtles and Implications for Human Health
Mercury contamination threatens many ecosystems worldwide. Methylmercury bioaccumlates at each trophic level, and biomagnifies within individuals over time. Long-lived turtles often occupy high trophic positions and are likely to accumulate mercury in contaminated habitats. Millions of turtles worldwide are sold in Asia for human consumption, and consumers may be at risk if turtles contain high ...
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Mercury concentrations in different tissues of turtle and caiman species from the Rio Purus, Amazonas, Brazil
Total mercury (Hg) concentrations of muscle, liver, blood, and epidermal keratin were measured in typically consumed, economically and culturally important species of turtle (Podocnemis unifilis and Podocnemis expansa) and caiman (Melanosuchus niger and Caiman crocodilus) from the Rio Purus in the Amazon basin, Brazil. Methylmercury (MeHg) concentrations were also measured in muscle tissue, ...
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Matrix Gemini Lims at work in Cancer research trials case study
Executive Summary The Roy Castle Lung Cancer Foundation (RCLCF) is a UK wide charity, dedicated to the defeat of lung cancer. It funds basic science research, tobacco control initiatives and work in lung cancer patient information, support and advocacy. RCLCF works towards defeating lung cancer through research, campaigning and education and gives practical and emotional support for patients and ...
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Innovative Diagnostic Development Urges Rare Disease Therapies
Rare diseases are characterized by their low prevalence, affecting a small number of people across the world. These diseases often come with significant challenges, including accurate diagnosis, availability of effective treatments, and limited resources for research and development. However, recent advancements in diagnostics technology hold promise for speeding up the field of rare disease ...
By Protheragen
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New Approaches to Label Proteins Help Track Disease
Scientists at the Francis Crick Institute and Imperial College London have developed a new way to study proteins released by cells, which may spawn new tools to track diseases, including cancer. Biomarkers are invaluable tools that enable physicians to study biology and disease, for example, diagnose disease from blood or tissue samples, predict whether a treatment is effective for an ...
By Profacgen
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Through a Simple Blood Test, Our Body’s Gut Bacteria Can Help Detect Early-stage Colorectal Cancer
Analysis of microbiome signatures in plasma for early CRC detection Colorectal cancer (CRC) represents the 3rd leading cause of cancer-related deaths in the United States. Patients diagnosed with distant stage of the disease represent 22% of all CRC cases and have 15% 5-years survival rates, in contrast to 91% 5-years survival rate of patients with localized disease at diagnosis, indicating how ...
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Label-based Protein Quantification Technology: iTRAQ, TMT, SILAC
Changes in the number of proteomes in a cell have a big effect on many aspects of life. For example, the occurrence and development of many diseases are often accompanied by abnormal expression of certain proteins. Quantitative proteomics is the accurate quantification and identification of all proteins expressed in a genome or all proteins in a complex mixed system. At present, quantitative ...
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What is a Liquid Nitrogen Storage Tank and What is it Used for?
A liquid nitrogen (LN2) storage tank is typically a multi walled vessel which features a high vacuum between the walls to provide excellent thermal insulation. Such vessels are often used in cold chain storage and transport applications. When the vessel is used to store or transport cryogenic liquids (such as liquid nitrogen or liquid helium) only, then the vessel is known as a liquid nitrogen ...
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Crispr and the Editing of Genes: To Help Revolutionize Biomedical Science
Scientists from MIT and Harvard University are placing their faith in a gene editing tool that may revolutionize the treatment of deadly diseases. CRISPR, which stands for Clustered Regularly Interspaced Short Palindromic Repeats, has the potential to unlock the next generation of treatments for conditions like cancer, ALS, or Alzheimer's. Learn how CRISPR is poised to change genome editing and ...
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Comprehensive Insights into Native Porcine Pancreatin: A Versatile Enzyme Preparation
Native Porcine Pancreatin, an enzymatic mixture derived from the porcine pancreas, has emerged as a fundamental component in various industries due to its unique enzymatic composition. Comprising amylase, lipase, and protease enzymes, this preparation is celebrated for its multifaceted applications and plays an indispensable role in the pharmaceutical, food, and biotechnology sectors. In this ...
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Montreal-developed probe could be breakthrough in finding cancer (Montreal CTV News)
A fibre-optic probe can detect errant cancer cells within healthy tissue during brain tumour surgery with close to 100 per cent accuracy and sensitivity, reducing the risk of recurrence and thereby increasing a patient’s survival time, say the Canadian researchers who developed the device. The hand-held, pen-like instrument, known as a Raman spectroscopy probe, is able to differentiate ...
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