Tumor Activity Articles & Analysis: Older
19 articles found
The reactivity of disulfide bonds can be adjusted by steric hindrance: α-methyl substitution significantly affects the reduction rate and resistance to thiol-disulfide bond exchange. For example, the best anti-tumor activity of SPDB-DM4 was obtained by substituting the linker of SAR-3419 with geminal dimethyl. ...
Antibody-PROTAC conjugates combine the catalytic properties of PROTAC with the tissue specificity of ADC, thereby overcoming the traditional limitations of targeting degraders and ADCs, and have great potential in targeting new targets.ADC with NIR-PIT Drug as PayloadNear-infrared photoimmunotherapy (NIR-PIT) drugs typically consist of tumor-specific monoclonal antibodies that ...
RTKs are abnormally highly expressed on the surface of tumor cells, leading to malignant proliferation of tumor cells, and are therefore also important targets for tumor treatment. Single-target monoclonal antibodies against RTKs have been widely used in tumor treatment. However, tumor cells can ...
In addition, Trop-2 is highly expressed in tumors and is associated with poor tumor prognosis. These characteristics all indicate that Trop-2 will become a good target for tumor treatment. ...
In vivo experiments showed that both GlueBody and GlueTAC treatment significantly inhibited tumor growth, with tumors treated with GlueTAC having a lower average weight compared to those treated with GlueBody. ...
In particular, linker design plays a key role in regulating ADC stability in systemic circulation and payload release efficiency in tumors, thereby affecting ADC pharmacokinetics (PK), efficacy, and toxicity profiles. ...
Researcher Insco said that we found that CDK13 protein can play the role of tumor suppressor in melanoma, and its mutation or deletion can lead to tumor occurrence. ...
Specific targeting: The reported targeting strategies such as antibody-PROTAC conjugates can effectively improve the recognition of PROTAC molecules on tumors; PROTACs are activated by light, folic acid or reactive oxygen species in tumors through modification groups, which is also an effective way to reduce the potential toxicity of systemic ...
So far, studies have found that it has anti-metastasis and anticancer activities, antioxidant, free radical scavenging, hypoglycemic, hypolipidemic and other pharmacological activities, and a large number of experimental results show that its biological activities are better than curcumin, such as antioxidant chloroquine-induced kidney damage, ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
The results showed that none of the three intermediate forms reprogrammed tumor cell surface antigenicity, but peptides with cancer-associated metalloproteinase 2 (MMP2) cleavable sites were able to activate CMV-CTL, implying that antibodies conjugated to engineered peptide antigens can effectively reprogram tumor cell surface antigenicity. To ...
The ultimate goal of cancer vaccines is to fully activate the immune system so that it can recognize tumor antigens and eradicate tumor cells, and nanotechnology possesses the qualities required to do this. Nanovaccine technology, as one of the candidates for cancer immunotherapy with configurable components and sequential integration, will most ...
Researchers at Jude Children's Research Hospital published a research paper entitled "The Deleting DNMT3A in CAR-T cells Enhancement Antitumor Activity Prevention" in the Science Translational Medicine. Studies have shown that knockdown of DNA methyltransferase 3α (DNMT3A) gene in CAR-T cells can prevent T cell failure and enhance anti-tumor ...
Bispecific antibodies that target tumors by engaging innate-like T cell subsets with inherent antitumor activity Bispecific antibodies that target tumors by engaging innate-like T cell subsets with inherent antitumor activity CD1d can be expressed by several hematologic malignancies Bispecific Vγ9Vδ2-T cell ...
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–toxic and non–immunogenic constructs, capable of delivering synergistically functioning drugs in vivo. The present study evaluates the efficacy of drug polymer self folding nano–conjugates of pectin–cisplatin to enhance blood circulating levels of cisplatin. Physical characterisation was done by DLS, zeta ...
Single and fractionated Whole-Body Irradiation (WBI) of the BALB/c mice with total doses of 0.1 or 0.2 Gy X-rays led to reductions in the number of pulmonary tumour colonies. Single and fractionated WBI with 0.1 or 0.2 Gy, as well as the fractionated exposure to 1.0 Gy X-rays, significantly stimulated: the cytotoxicity of macrophages (Mφ) and Natural Killer (NK) cells mediated mainly by ...
To address if the modulation of immunity balance by low dose radiation is involved in the enhancement of the anti-tumour function, we examined the effect of 0.5 Gy γ-irradiation on the Th1/Th2 immunity balance in Ehrlich Solid Tumour (EST)-bearing mice. Repeated 0.5 Gy γ-irradiation significantly delayed the growth of tumours. The cytotoxic activities of Natural Killer (NK) cells and Cytotoxic T ...
The forkhead box M1 (FoxM1) transcription factor is overexpressed in many cancers, and in mouse models it is required for tumor progression. FoxM1 activates expression of the cell cycle genes required for both S and M phase progression. ...
Based on the reports suggesting that exposures to low doses of ionising radiation may impede tumour development and/or trigger the activity of natural anti-neoplastic defence mechanisms we demonstrate in the present study that single whole-body irradiations of mice with 0.1 or 0.2 Gy X-rays significantly decreased the number of the induced tumour colonies in the lungs and that the effect was ...