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Tumor Cells Articles & Analysis: This-Month
3 articles found
One such approach involves the repositioning, or repurposing, of drugs already FDA approved in either non-oncology disease states and/or approved in a limited number of tumor types. The repurposing of these drugs for new indications represents an opportunity to circumvent the time and investment that must go into the discovery, development, and approval of new compounds (1). ...
In the case of human ovarian epithelial cells, SV40 plays a pivotal role. The large T antigen of SV40 has the capability to bind and inactivate tumor suppressor proteins such as p53 and Rb, which are critical regulators of the cell cycle. ...
Tumor cells divide at a much faster rate than normal cells because they show significant dysregulation in cell cycle-related proteins. ...