tumor detection Articles
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Luminex Multiplex Assay
Principle of Luminex Multiplex Assay Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test ...
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The Tumor Marker: Vascular Endothelial Growth Factor 165 (VEGF165)
Tumors and Blood Vessel Growth Tumor, as an abnormal mass of cells, has blood vessels of various sizes that can be seen everywhere on the surface and deep within it. Nutrients for life are continuously supplied to the depths of tumor cells through these blood vessels. As the tumor continues to grow, nearby blood vessels also undergo rapid and chaotic growth, with these newly formed capillaries ...
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An Automated and Accurate Methodology to Assess Ki-67 Labeling Index of Immunohistochemical Staining Images of Breast Cancer Tissues
Automatic scoring of Ki-67 with digital image analysis would improve the accuracy of the diagnostic. However, automatic Ki-67 assessment is very challenging due to complex variations of cell characteristics. In this paper, we propose an integrated framework for accurate Ki-67 scoring. The main contributions of our method are: a robust cell detection algorithm to detect all tumor and non-tumor ...
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The ins and outs of TCR-T cell therapy
Adoptive cell transfer (ACT) therapy is one of the most effective therapeutic options for tumor immunotherapy that is currently emerging in clusters. Chimeric antigen receptors (CARs) and engineered T cell receptors (TCRs) are the main adoptive immunotherapies in recent years. TCR-engineered T cells express tumor antigen-specific receptors with alpha and beta chains generated from high-quality, ...
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Possible treatment of human multiple myeloma found
Multiple myeloma is an essentially incurable plasma cell cancer with a very poor prognosis for patients; however, in a recent study published in Science Translational Medicine entitled "Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the protein CD98 heavy chain," scientists from Osaka University in Japan have discovered the CD98 heavy chain, a common ...
By Profacgen
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Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture technology to enrich DNA from the whole exome regions, enabling high-throughput sequencing. WES offers a simpler, more cost-effective, ...
By CD Genomics
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Nanostics Announces the Launch of its Bladder Cancer Clinical Study Identifying Disease Predictors for Early Detection of Bladder Cancer
Clinical study launched in June 2022 with patient recruitment in Alberta with plans to expand to further sites across North America. The aim of the study is to validate a novel and minimally invasive liquid biopsy test for bladder cancer diagnosis using Nanostics’ ClarityDX® diagnostic platform. The study is supported in part by the Alberta Innovates AICE-Concepts Program with a ...
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Nanobodies Definition, Structure, Advantages and Applications
What is a Nanobody?Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages. The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in ...
By BOC Sciences
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