tumor dna Articles
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Selection against puma gene expression in myc-driven b-cell lymphomagenesis
The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Eµ-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that 75% of Eµ-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately ...
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New Findings from Universal DX: Through a Simple Blood Test, Our Body`s Gut Bacteria Can Help Detect Early-stage Colorectal Cancer
Company Presents Data at ESMO Congress Showing Link Between Microbiome Bacteria and Early Colorectal Cancer Detection (September 12, 2022) CAMBRIDGE, MA. - Universal Diagnostics (Universal DX), a bioinformatics and multi-omics company on a mission to transform cancer into a curable disease, today announced the results of a proof of principle study demonstrating that the analysis of microbiome ...
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MK-4101
MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma. target:SMO In vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice. In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in ...
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Ildong’s subsidiary secures 1st anticancer drug pipeline
Idience, a subsidiary of Ildong Pharmaceutical, has acquired IDX-1197, an immunotherapy drug, as its first pipeline. The introduction of the new pipeline came four months after Ildong Pharmaceutical established Idience as a no research and development only (NRDO) company in May. With the acquisition, Idience has decided to launch phase 1b and 2a clinical trial for the drug this year, which will ...
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How the Breuer Lab tracks their sample information at every step of their research
Dr. Eun-Kyoung Breuer is an Assistant Professor and an Associate Director of the Radiobiology Program in the Department of Radiation Oncology at Loyola University Chicago. Her lab's research focuses on understanding the role that tumor suppressor genes play in the DNA damage response pathway and in breast cancer regulation. A centralized information management approach Doing research focuses on ...
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CADM: A New Generation of Tumor Suppressor Genes
About Tumor Suppressor Genes A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. It usually facilitates apoptosis. With its absence, the human body will be functioning without its “brake” of cell proliferation. Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. Here are some key ...
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Optimization of Three Elements of ADC Drugs
Structurally, an ADC consists of monoclonal antibodies (Antibody) that target specific antigens on tumor surfaces, cytotoxic drugs (drugs) that kill tumor cells, and linkers (Conjugate/ linkers) that conjugate cytotoxic drugs to antibodies. The link between the antibody and linker is controlled by the coupling method, which determines the DAR value of the drug and affects the stability and PK ...
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Preventive cancer vaccine based on neoantigens gets put to the test
Studying the vaccine in dogs could provide insight into its effectiveness in people What if someone told you that a vaccine shot could prevent you from getting multiple types of cancer—ones as different from each other as breast cancer and lymphoma? Stephen A. Johnston, cofounder of the health-care start-up Calviri and a scientist at Arizona State University’s Biodesign Institute, ...
By Calviri
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