tumor necrosis factor alpha Articles
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The putative α-1,2-mannosyltransferase AfMnt1 of the opportunistic fungal pathogen aspergillus fumigatus is required for cell wall stability and full virulence
Proteins entering the eukaryotic secretory pathway commonly are glycosylated. Important steps in this posttranslational modification are carried out by mannosyltransferases. In this study, we investigated the putative {alpha}-1,2-mannosyltransferase AfMnt1 of the human pathogenic mold Aspergillus fumigatus. AfMnt1 belongs to a family of enzymes that comprises nine members in Saccharomyces ...
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RelB Modulation of Ikappa Balpha Stability as a Mechanism of Transcription Suppression of Interleukin-1alpha (IL-1alpha ), IL-1beta , and Tumor Necrosis Factor Alpha in Fibroblasts
Members of the NF-B/RelB family of transcription factors play important roles in the regulation of inflammatory and immune responses. RelB, a member of this family, has been characterized as a transcription activator and is involved in the constitutive NF-B activity in lymphoid tissues. However, in a previous study we observed an overexpression of chemokines in RelB-deficient fibroblasts. Here we ...
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Relb modulation of ib stability as a mechanism of transcription suppression of interleukin-1 (il-1), il-1, and tumor necrosis factor alpha in fibroblasts
Members of the NF-B/RelB family of transcription factors play important roles in the regulation of inflammatory and immune responses. RelB, a member of this family, has been characterized as a transcription activator and is involved in the constitutive NF-B activity in lymphoid tissues. However, in a previous study we observed an overexpression of chemokines in RelB-deficient fibroblasts. Here we ...
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Bioaccesible heavy metals‐sediment particles from Reconquista River induce lung inflammation in mice
The Reconquista River (RR), one of the most polluted watercourses in Argentina, receives effluent discharges from heavily industrialized and highly populated settlements. During winter and summer, the floodplain remains dry, producing the oxidation of sulfide and organic matter present in the sediment, making heavy metals more bio‐accessible. Dispersion of this sediment occurs, and thus harmful ...
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Suppressive effect on activation of macrophages by lactobacillus casei strain shirota genes determining the synthesis of cell wall-associated polysaccharides
Although many Lactobacillus strains used as probiotics are believed to modulate host immune responses, the molecular natures of the components of such probiotic microorganisms directly involved in immune modulation process are largely unknown. We aimed to assess the function of polysaccharide moiety of the cell wall of Lactobacillus casei strain Shirota as a possible immune modulator which ...
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A Novel, High-Throughput Platform to Characterize Novel IBD Therapeutics
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. TNF-a activation of ...
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Autoimmune Diseases Targets
Thymic Stromal Lymphopoietin (TSLP) is a multifunctional cytokine that acts on various cell types, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils, and innate lymphoid cells, affecting their maturation, survival, and recruitment. It is well-known for its role in promoting type 2 immune responses, such as allergic diseases. In 2021, a monoclonal antibody targeting ...
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Inflammatory Cytokines Profile
Cytokines are classified according to their different roles in the inflammatory response: pro-inflammatory cytokines and anti-inflammatory cytokines. Pro-inflammatory Cytokines Interleukin-1 (IL-1) IL-1 is a proinflammatory cytokine that activates a variety of immune and inflammatory cells and is secreted mainly by monocytes/macrophages, neutrophils and endothelial cells. IL-1 consists of two ...
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Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice
Highlights The depletion of Roseburia is associated with alcohol consumption in human cohorts R. intestinalis ameliorates the experimental ALD in mice regardless of viability Flagellin from R. intestinalis protects on ethanol-disrupted gut barrier functions The ethanol-induced gut microbiota dysbiosis is restored by R. intestinalis Summary Although a link between the gut microbiota ...
By KoBioLabs
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Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2
The recent COVID-19 pandemic again highlighted the urgent need for broad-spectrum antivirals, both for therapeutic use in acute viral infection and for pandemic preparedness in general. The targeting of host cell factors hijacked by viruses during their replication cycle presents one possible strategy for development of broad-spectrum antivirals. By inhibiting the Raf/MEK/ERK signaling pathway, ...
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