Type 1 Diabetes Articles & Analysis: Older
47 articles found
Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of diabetes is increasing year by year. Diabetes has various types and requires long-term treatment. Antidiabetic drugs are essential for ...
Abstract Background: Assessment of short-term glycemic control can facilitate monitoring of diabetes development in at-risk individuals and monitoring response to lifestyle modification or medication. We evaluated salivary protein glycosylation levels as a novel, noninvasive, short-term glycemic index in comparison to hemoglobin A1c (HbA1c), fructosamine, 1,5-anhydroglucitol ...
Assessment of C-peptide levels can identify individuals at risk for or with type 1 diabetes with residual β-cell function in whom β cell-sparing interventions can be evaluated, and can aid in distinguishing type 2 diabetes from Latent Autoimmune Diabetes in Adults and late-onset ...
Diabetes, specifically Type 1 and Type 2 Diabetes Mellitus, remains one of the most commonly encountered metabolic diseases worldwide. ...
The most common forms of diabetes are type 1 diabetes and type 2 diabetes. Type 1 diabetes (once known as insulin-dependent diabetes or juvenile onset diabetes) is characterized by insufficient insulin production ...
IL-2 signals through heterodimerization of the cytoplasmic domains of IL-2R beta and gamma c, mainly activating three signaling pathways: phosphatidylinositol 3-kinase (PI3K)/AKT, Ras-MAP kinase, and the JAK-STAT pathway (Figure 1). These three signaling pathways collectively mediate cell growth, survival, activation, and the induction of differentiation and death. ...
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
Metformin is a classic first-line hypoglycemic agent for patients with type 2 diabetes, and is an essential drug in combination regimenes. However, as the evidence is updated, the idea of drug selection for first-line treatment is changing. GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic ...
In addition, our previous study also found that tetrahydrocurcumin has a good therapeutic effect on metabolic syndrome, obesity type 2 diabetes, hypertension, insulin resistance syndrome and other related diseases, and has a wide range of application prospects. 1.Hypoglycemic Effect Murugan P et al. induced type 2 ...
Biolingus explores the development of a sublingual dual incretin inhibitor. BioLingus will position these products in the “epidemic” markets of obesity and type II diabetes : More than 400 MM people suffer from diabetes today. The global type 2 diabetes market is expected to grow to $58.7 billion by 2025, with an annual growth rate of 6.5%, according to research and consulting ...
Our sublingual “insulin+” product will be positioned in a particular segment of this market : it will be prescribed for type II diabetes patients, who do not respond sufficiently to GLP-1 analogues alone. ...
The aim of this project is to develop low dose IL-2 for treatment of early onset juvenile Type I diabetes. Low dose injectable IL-2 in animal models has been shown to restore the balance between regulatory and effector T cells and, in this way, can help to reverse autoimmunity and the development of type I diabetes. Looking ahead, we anticipate that having a suitable oral formulation of IL-2 to ...
Liraglutide and exenatide are both belonging to the class of diabetes products called GLP-1 analogues. The GLP-1 analogues have established themselves in the past years as one of the superior drug classes for treatment of diabetes type II in terms of blood glucose lowering and weight loss. ...
HFpEF is a complex disease which accounts for more than half of all heart failure (HF) hospital admissions and is an increasing disease burden. [1] The prevalence of HFpEF is climbing, reflecting an increasingly elderly and comorbid population, as well as reinforcing the need for more effective therapies.[2] SGLT2is are a class of anti-diabetic drugs that have ...
Linda Yip has been conducting research at Stanford, focusing on the identification and characterization of genes involved in the pathogenesis of Type 1 diabetes. Among other distinctions, she was selected as the 2016 recipient of its Young Investigator Award by the Network of Pancreatic Organ Donors with Diabetes. ...
A 53-year-old man visited his doctor concerned about a spreading rash underneath his arms for the past 3 weeks. He initially thought it was an allergic reaction to a new deodorant, but it wasn’t itchy, and it persisted after stopping the deodorant. The patient had a history of type 2 diabetes. On examination, a broad, well-demarcated, thin, scaly plaque was seen extending from the ...
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According to the Centre for Disease Control and Prevention, CDC report 2017; 30.3 million Americans – 9.4 percent of the U.S. population had diabetes in 2015. Home blood glucose monitoring is useful to determine the daily adjustments in treatment or insulin intake. It is advised to follow doctor's recommendations about how often to test the glucose levels. According to an article published ...
Patient History Patient is a 40-year-old female with a history of type 2 diabetes. Patient presented to the Emergency Room with a diabetic foot ulcer and infection. The surgeon took the patient to the OR for debridement, drained the infection, and started antibiotics. The patient was treated with advanced modalities that included NPWT and a bioengineered skin substitute. Primary Diagnosis ...
Mitochondria play a key role in maintaining cellular health and viability, and their dysfunction not only contributes to the development of many human diseases such as neurodegenerative diseases, cardiovascular diseases, obesity and type II diabetes, but also reduces oocyte quality and early embryonic development in animals. ...
What is diabetic neuropathy? The most common complication of diabetes is neuropathy, which is nerve damagecaused by high blood sugar. Most neuropathy affects the legs, hands and feet and usually presents as numbness, pain or tingling. Diabetic neuropathy can also seriously impact the heart, blood vessels, digestive system and the kidneys. Symptoms can range from mild discomfort to extreme pain. ...