vaccination Articles
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The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpe
ABSTRACT Background: Although development of an HSV vaccine is a priority there is currently no vaccine available. The recent failure of subunit vaccines suggest that presentation of more antigens via a live attenuated vaccine may be required for protection. We therefore evaluated VC2. a live attenuated HSV vaccine, engineered to be unable to enter into neuronal axons. Methods: VC2 pathogenesis ...
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Top 10 Tips to improve flu vaccine uptake in care home and home care staff
This year is not a typical year. On average, flu kills over 11,000 people each year and hospitalises many more. The potential impact of flu and COVID-19 circulating at the same time this year has the potential to take many more lives. ‘Protect yourself, your family and our patients from flu this winter’ is the theme for the seasonal influenza campaign this year and with the current ...
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Immunity development following oral vaccination against Actinobacillus pleuropneumoniae in a mouse model
Porcine contagious pleuropneumonia caused by Actinobacillus pleuropneumoniae (Ap) is a deadly disease in pigs. In this work, we attempt to determine immunogenic properties of an oral Ap vaccine in a mouse model. Formalin-inactivated, whole-cell Ap suspension is included in two vaccine formulations: the classic injectable form with aluminium adjuvant and the oral form encapsulated into ...
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The Art and Science of Shipping Flu Vaccines
CSL Seqirus delivered a record 135 million doses of flu vaccines globally last year, here’s how we make such a feat happen. Influenza vaccine manufacturing is an intricate and complex process that culminates in the summer months, when U.S. flu vaccine manufacturers receive regulatory approval from the FDA for the season’s vaccines. The manufacturers then prepare to distribute ...
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Model-driven engineering for vaccine product data compliance
Data quality is widely considered as a very serious problem for the majority of companies due to the specificities of each business context and the lack of adapted solutions. In this paper, we present the benefits of model-driven engineering (MDE) concepts in ensuring the interconnection of different business contexts specifications by providing a linked structure of models. This enables to ...
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Developing Plasmodium falciparum malaria vaccines for populations living in areas with stable parasite transmission
Individuals living in areas with stable transmission of Plasmodium falciparum parasites develop substantial protective immunity to the disease during childhood. Because of naturally acquired immunity, which appears mainly to target parasite-encoded Variable Surface Antigens (VSA) on the Infected Erythrocytes (IE), severe and life-threatening disease among adults in such areas is rare. However, ...
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Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials
Abstract Background Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. Methods A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig model of genital herpes. Three doses of intramuscular (IM) vaccine were provided followed by ...
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Safety and immunogenicity of bivalent inactivated vaccine against haemorrhagic fever with renal syndrome in a phase II trial on healthy Chinese volunteers
We have developed a cell culture-derived, inactivated bivalent vaccine against both Haemorrhagic Fever with Renal Syndrome (HFRS) viruses 84 Fli (type I) and L99 (type II). This purified vaccine was tested in the clinical phase I/II trial in healthy non-infected adults in China. About 518 volunteers in Southern region and 650 volunteers from the Northern region of China were vaccinated. ...
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Beyond Just Peptide Antigens: The complex world of peptide-based cancer vaccines
Therapeutic vaccines may well be the next wave of immunotherapy for cancer treatment. Peptide-based vaccines will play a pivotal role in the field. How is a peptide vaccine designed? What other factors such as adjuvants etc should be considered? Can Immunol oncological agents be synergetic with peptide vaccines? Read the full article: Beyond Just Peptide Antigens: The complex world of ...
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Source of Glycerol and Its Use in Vaccine Manufacturing
Glycerin, a versatile and widely used compound, finds its application in various industries, including pharmaceuticals. By understanding the multifaceted applications of glycerin in vaccine formulation, storage, and delivery, pharmaceutical manufacturers can optimize their vaccine production processes to ensure superior quality and effectiveness. Among the numerous components and additives ...
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Single-replication BM2SR vaccine provides sterilizing immunity and cross-lineage influenza B virus protection in mice
Abstract Both influenza A and B viruses cause outbreaks of seasonal influenza resulting in significant morbidity and mortality. There are two antigenically distinct lineages of influenza B virus, Yamagata lineage (YL) and Victoria lineage (VL). Since both B lineages have been co-circulating for years, more than 70% of influenza vaccines currently manufactured are quadrivalent consisting of ...
By FluGen, Inc.
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Covid-19: Oxyweld supports the manufacturers of freezers in brazing activity
Founded in 1981 Oxyweld provides a complete range of eco-fnendly oxyhydrogen gas generators for brazing enabling producers to improve their brazing process in terms of quality of the joints and safety for operators. Oxyweld is official supplier of many multinationals in the HVACR industry. In this particular period of the year the company works close to the manufacturers of freezers to help them ...
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HIV-1 subtype C vaccine: waiting in wings for the human trials
India has more than 5 million people infected with HIV-1 and this number is likely to increase in coming years. It is estimated that by the turn of this decade more than 10 million people would have been infected with this virus. More than 90% of these infections are due to subtype C. Therefore, it is imperative that a vaccine be developed based on local circulating subtype and tested for ...
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7 Vaccine Monitoring Essentials Required by the CDC
All vaccines are temperature sensitive and require the proper environmental conditions to ensure vaccine stability. Exposure to extreme heat or cold can be catastrophic to millions of vulnerable people, especially children, who would otherwise go unvaccinated. To ensure the safety and potency of vaccines, the VFC Program, which provides vaccines to children at no cost, has strict requirements in ...
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Freshliance Temperature Humidity Recorders help vaccine cold chain
Due to the particularity of vaccines, vaccines need to be kept in a constant and suitable temperature environment during transportation and storage, and different vaccines require different environmental temperatures. Therefore, vaccines often need to be processed in the cold chain, and Temperature Humidity Recorders with quality certification are required to monitor and record the temperature of ...
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Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1 (F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
Abstract Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice against herpetic keratitis following ocular ...
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Internal Auditing for Vaccine Storage
For research facilities, hospitals, clinics, doctor offices and other medical establishments, vaccine storage is absolutely critical to ensuring the accuracy and efficiency of vaccines administered. Although regulatory organizations carry out standard audits to examine vaccine storage procedures, it is important to conduct internal auditing. Especially in the times we are facing now with a global ...
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Rational`s Experimental Herpes Vaccine Shows Preclinical Promise
Rational Vaccines said findings from a pilot study showed that RVX201 led to a reduction in recurrent genital lesions when compared to gD2-alum/MPL vaccine in animal studies. Rational's Experimental Herpes Vaccine Shows Preclinical Promise Rational Vaccines said findings from a pilot study showed that RVX201 led to a reduction in recurrent genital lesions when compared to gD2-alum/MPL vaccine ...
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mRNA vaccine for the pregnant produces antibodies that are passed on to the child and remain for at least 6 months
As the COVID-19 pandemic enters its third year, efforts to mitigate the risk of infection remain critical, especially for vulnerable populations. Recently, Andrea Edlow et al. of Massachusetts General Hospital published a study in the journal JAMA entitled "Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection". The study showed that ...
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Self-amplifying RNA as a tool to tackle emerging flavivirus outbreaks: lessons learned from the COVID-19 pandemic
Background Outbreaks of multiple Flaviviruses have afflicted humankind for centuries due to their rapid spread predominantly by arthropod vectors. Global warming has caused epidemics to emerge in previously unaffected regions. The SARS-CoV-2 outbreak and subsequent race in vaccine development can provide strategies to the scientific community to avoid a flavivirus pandemic. The COVID-19 battle ...
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