vaccine delivery Articles
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Vaccine Projects
Abera’s vaccine delivery platform works as a plug-and-play system where known or novel antigens can be engineered onto our delivery platform to create effective, multivalent vaccines that are cost-effective and fast to produce. We actively work together with academia and industry to enable the use of our vaccine delivery platform in design and development of new vaccines. Many of these ...
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Protein-loaded chitosan nanoparticles modulate uptake and antigen presentation of hen egg-white lysozyme by murine peritoneal macrophages
Chitosan binds to negatively charged tripolyphosphate (TPP) by an electrostatic interaction driven by its positively charged amino group. This interaction allows developing stable nanoparticles suitable as a carrier and controlled release system for drugs and vaccines. We study the effect of chitosan nanoparticles (CNp) on the uptake and antigen presentation of the model protein hen-egg white ...
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AKCP Wireless Tunnel COVID-19 Vaccine Monitoring Solution
AKCP Wireless Tunnel Solution Deployed for COVID-19 Vaccine Delivery and Storage In response to the pandemic, the Pfizer COVID-19 vaccine has been approved for use throughout the world. As the vaccine is based on mRNA technology it requires refrigeration to temperatures as low as -80°C. This is a challenge for the cold chain logistics industry. Monitoring the COVID-19 vaccine during delivery ...
By AKCP
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Internal Auditing for Vaccine Storage
For research facilities, hospitals, clinics, doctor offices and other medical establishments, vaccine storage is absolutely critical to ensuring the accuracy and efficiency of vaccines administered. Although regulatory organizations carry out standard audits to examine vaccine storage procedures, it is important to conduct internal auditing. Especially in the times we are facing now with a global ...
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Why Cold Chain Monitoring is Critical in the Delivery of Vaccines
Vaccine monitoring throughout the cold chain until final delivery is essential. Vaccines are a key component in our health care system. One of the most cost-effective and efficient public health strategies is immunization. The end of many disease outbreaks can be directly attributed to the development of their respective vaccines. They have an immense societal contribution, which is why it is ...
By AKCP
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mRNA Delivery System
RNA is a hydrophilic, negatively charged macromolecule, and its ability to autonomously transmembrane is limited. Therefore, how to efficiently deliver mRNA to the cytoplasm and play a corresponding role is one of the key issues that limit the application of RNA therapy. The wide range of applications of therapeutic mRNA requires efficient and safe delivery methods. An ideal delivery system ...
By BOC Sciences
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Why Vaccine Cold Chain Monitoring is Critical
Vaccines are a key component in our health care system. One of the most cost-effective and efficient public health strategies is immunization. The end of many disease outbreaks can be directly attributed to the development of their respective vaccines. They have an immense societal contribution, which is why it is crucial that the delivery of vaccines through the cold chain is monitored and ...
By AKCP
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Microneedle Patch Technology: Revolutionizing Drug Delivery
Introduction Advancements in medical technology have led to innovative solutions for various healthcare challenges. One breakthrough is microneedle patch technology, holding immense promise in revolutionizing drug delivery. These patches consist of micron-sized needles that painlessly penetrate the skin's outermost layer, enabling the controlled release of medications or therapeutic agents. In ...
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Source of Glycerol and Its Use in Vaccine Manufacturing
Glycerin, a versatile and widely used compound, finds its application in various industries, including pharmaceuticals. By understanding the multifaceted applications of glycerin in vaccine formulation, storage, and delivery, pharmaceutical manufacturers can optimize their vaccine production processes to ensure superior quality and effectiveness. Among the numerous components and additives ...
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Applications of Liposomal Drug Delivery System Technology
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, ...
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FluGen Announces First Subject Dosed in Phase 1b Clinical Trial of its Intranasal M2SR Flu Vaccine, Co-Administered with High Dose Vaccine, in Older Adults
Study will measure immune responses generated by M2SR and high dose vaccine separately and in combination in the highly vulnerable 65-85 years old population – Funded by the US Department of Defense, this study is expected to yield topline data in 2H 2022 – MADISON, Wis., June 22, 2022 /PRNewswire/ — FluGen, Inc., a clinical-stage vaccine company transforming vaccine ...
By FluGen, Inc.
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Air Delivery of Super-Cooled COVID-19 Vaccines
There are several potential COVID-19 vaccines that may soon be available for widespread distribution. In particular, the United Kingdom has recently approved Pfizer’s vaccine, and the U.S. Food and Drug Administration is considering extending Emergency Use Authorization to the Pfizer and Moderna vaccines. That is certainly promising news, but storage, transportation, and delivery of these ...
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Vaccine Cold Storage Rooms - How They Work and are Maintained
Vaccine Storage and Handling Vaccines and other medical products are essential parts of a healthy society. They provide relief from diseases and suffering. They are designed to improve the quality of life for people. As with any other product, they are manufactured in facilities located near urban centers. When shipped elsewhere, transportation is provided by a cold chain process in place to ...
By AKCP
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A Brown pathology professor may have developed a revolutionary new approach to battling one of the world’s deadliest diseases
Jonathan “Jake” Kurtis was riding a night train from Nairobi to Mombasa when he first began to feel sick. Then a 20-year-old Brown junior, Kurtis had gone to the restaurant car for a curry and stayed up late drinking beer with some Americans he’d met. By the time he got back to his sleeper car, he had a vicious headache. “I thought God had visited upon me a righteous ...
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Temperature Sensitivity of Vaccines
All vaccines are sensitive to extreme heat and extreme cold and require both proper vaccine storage and management to avoid any loss of potency. Immunization is the most effective and economical public health measure against infectious diseases that cause morbidity or mortality. Immunization prevents two to three million deaths every year from diseases such as hepatitis, pertussis (whooping ...
By AKCP
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Temperature Monitoring Supports the Vaccine Cold Chain
Vaccines play a vital role in society by preventing and eradicating various diseases. Newly developed vaccines such as pneumococcal conjugate vaccine (PCV) and rotavirus vaccines have the ability to save a million lives per year. The response to the 2019/2020 global COVID-19 pandemic resulted in mRNA ultra-low temperature vaccines being developed. It is essential for the efficacy of the vaccines ...
By AKCP
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mRNA vaccine for the pregnant produces antibodies that are passed on to the child and remain for at least 6 months
As the COVID-19 pandemic enters its third year, efforts to mitigate the risk of infection remain critical, especially for vulnerable populations. Recently, Andrea Edlow et al. of Massachusetts General Hospital published a study in the journal JAMA entitled "Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection". The study showed that ...
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Don`t Throw Away Your Shot...the Cold Truth About Vaccine Handling and Storage
Overview In modern times, vaccines have been widely used to keep people healthy by protecting them from serious illnesses and diseases. Worldwide, vaccines annually prevent millions of deaths, and their utilization is responsible, in many parts of the globe, for the nearly total eradication of numerous diseases, including polio, measles, and smallpox. According to the U.S. Centers for Disease ...
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Drug-Loaded Liposomes: Tiny Spheres with Big Potential
Imagine tiny bubbles, smaller than a red blood cell, carrying powerful medicines directly to diseased cells. This isn't science fiction, it's the cutting edge of drug delivery with drug-loaded liposomes. What are liposomes? Liposomes are microscopic spheres made from phospholipids, the same fatty molecules that make up cell membranes. These phospholipids naturally arrange themselves in ...
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Regeneron’s High Profile Success? Demand for COVID-19 prophylactics – what role for Pichia expression technology to assist access
With Regeneron’s high profile, single-person, single-site, clinical trial proving successful (along with much supporting other clinical data!), will neutralising antibodies surf the second wave? Our COVID-related blogs focus on capacity and cost of making the treatments and understanding opportunities or bottlenecks in large scale provision and new innovations. In this context, we review ...
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