vaccine targets Articles
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Self-amplifying RNA as a tool to tackle emerging flavivirus outbreaks: lessons learned from the COVID-19 pandemic
Background Outbreaks of multiple Flaviviruses have afflicted humankind for centuries due to their rapid spread predominantly by arthropod vectors. Global warming has caused epidemics to emerge in previously unaffected regions. The SARS-CoV-2 outbreak and subsequent race in vaccine development can provide strategies to the scientific community to avoid a flavivirus pandemic. The COVID-19 battle ...
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Identification and analysis of epitope-based malarial vaccine targets using computational biology
Malaria is a vector-borne infectious disease caused by protozoan parasite of the genus Plasmodium. The malaria vaccine which has been studied is designed to induce immunity to the sporozoite and to kill sporozoite-infected liver cells. A combination of bioinformatics approach and computational tools are used to screen and select antigen sequences as potential T-cell epitopes of supertype human ...
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Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials
Abstract Background Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. Methods A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig model of genital herpes. Three doses of intramuscular (IM) vaccine were provided followed by ...
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The Significance of Raw Enzymes in the Success of mRNA Vaccines
In the ever-evolving landscape of global healthcare, mRNA vaccines have emerged as an excellent tool in the fight against infectious diseases. This article explores the intricate and indispensable role that raw enzymes play in the manufacturing of mRNA vaccines, delving deep into their significance and impact on vaccine production. As we venture into this fascinating world, we will gain a ...
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Bioinformatics Analysis Brings Disease Genomics Research to a Crossroads
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present ...
By CD Genomics
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Creative Enzymes Launches Advanced Neuraminidase for Flu Vaccine Development
Creative Enzymes, a professional enzyme provider located in New York, always hammers at researches and trials in order to provide customers with various enzymes as many as possible. Last week, the product manager of Creative Enzymes announced the launch of neuraminidase, which is expected to further develop a new universal influenza vaccine. Neuraminidase is a drug target to prevent the spread ...
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Nature Biotechnology: Generation of a live attenuated influenza A vaccine by proteolysis targeting
Longlong Si's research group from the Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, published a research titled "Generation of a live attenuated influenza A vaccine by proteolysis targeting" in Nature Biotechnology. Using influenza virus as a model virus, the team established the technology of protein degradation targeting virus as an ...
By Profacgen
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Maimonides Institute for Biomedical Research of Cordoba (IMIBIC) - Case Study
Name: Eduardo Chicano-Galvez Job Title: Head of Proteomics Unit Company: Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain Eduardo Chicano-Galvez, Head of Proteomics, IMIBIC Peak provides nitrogen for Proteomics Eduardo Chicano-Galvez and his team at Maimonides Institute for Biomedical Research of Cordoba (IMIBIC) use a Peak Infinity 1032 compressor-less ...
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Long Read Sequencing Helps HLA Typing
HLA, human leukocyte surface antigen, a series of tightly interlocking motifs on the short arm of human chromosome 6, is the central basis for the immune system to recognize and differentiate between allogeneic substances. It is highly polymorphic and corresponds to a complex acquired immune system. It is importantly associated with a variety of autoimmune diseases, tumors, and infectious ...
By CD Genomics
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Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated vaccine against herpes simplex virus type 1 (HSV-1), a widespread human pathogen that can cause ...
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A Brown pathology professor may have developed a revolutionary new approach to battling one of the world’s deadliest diseases
Jonathan “Jake” Kurtis was riding a night train from Nairobi to Mombasa when he first began to feel sick. Then a 20-year-old Brown junior, Kurtis had gone to the restaurant car for a curry and stayed up late drinking beer with some Americans he’d met. By the time he got back to his sleeper car, he had a vicious headache. “I thought God had visited upon me a righteous ...
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Peptide Vaccine Design
Vaccines are considered one of the most successful medical interventions in the past few centuries, aiming to harness the human immune system and generate lasting protection against specific diseases. Traditional vaccines rely on the use of inactivated pathogens to trigger an immune response. However, many of these formulations carry a high risk of causing allergies or autoimmune reactions. ...
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Four Novel Drug Delivery Systems You Should Know
In the field of medicine, effectively delivering drugs to the target site in the body is crucial for successful treatment. Over the years, several innovative drug delivery systems have been developed to improve drug efficacy and patient outcomes. In this article, we will discuss four novel drug delivery systems that have shown promising results in recent research. These systems include ...
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Unveiling the Potential of Premade RNA-LNP Products
Introduction RNA Lipid Nanoparticles (LNP) technology has rapidly gained prominence in the health and scientific domain, primarily due to its significant role in carrying the mRNA of the COVID-19 vaccines developed by Pfizer/BioNTech and Moderna. Yet, the potential of this technology spans beyond the confines of these vaccines or even the health industry. As research into premade RNA-LNP products ...
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Revealing the Details of Changes in Spike Proteins of SARS-CoV-2 Omicron Mutant Strains
The interesting SARS-CoV-2 omicron mutant strain evades immunity mediated by antibodies from vaccination or infection with early mutants due to the accumulation of a large number of spike mutations. Recently, in a research report titled "Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement" published in Science, scientists from institutions such as the University of ...
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Preventive cancer vaccine based on neoantigens gets put to the test
Studying the vaccine in dogs could provide insight into its effectiveness in people What if someone told you that a vaccine shot could prevent you from getting multiple types of cancer—ones as different from each other as breast cancer and lymphoma? Stephen A. Johnston, cofounder of the health-care start-up Calviri and a scientist at Arizona State University’s Biodesign Institute, ...
By Calviri
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