vascular system Articles
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Novel ‘3D’ Stent Improves Clinical Status in Femoropopliteal Disease Patients
PARIS, France—A "3D" helical stent that mimics the natural vascular curvature helps improve clinical symptoms and walking distance at 12 months in patients with femoropopliteal disease, according to results presented Tuesday, May 21 at EuroPCR 2013. For the Mimics study, researchers led by Stephan H. Duda, MD, of Jewish Hospital Berlin (Berlin, Germany), randomized 76 patients with ...
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How to Choose Antifreeze
Non-freezing liquid for cars is a product of mass use. It is not possible to do without it in the cold season, because this substance allows to keep car windshields clean, thereby providing good visibility to the driver and improving road safety. Today the market of automobile goods is quite diverse, so you can find antifreeze of both domestic and foreign production without any problem. We ...
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The first CRISPR gene editing of vascular endothelium was made possible thanks to nanoparticles
The vascular endothelium is a single layer of endothelial cells that lines the surface of the vascular lumen, and it plays an important role in maintaining vascular homeostasis and tissue fluid balance. Many disorders, such as coronary artery disease, stroke, bronchopulmonary dysplasia, and pulmonary hypertension, are caused by endothelial dysfunction. Genome editing in endothelial cells can also ...
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Three generations of ADC: Nearly a decade of development-PII
Kadcyla and second-generation non-cleavable linkers Alternative linker design methodologies are still under development. Immunogen discovered a very powerful ADC by an accidental discovery. The lysine residue of trastuzumab is linked to DM1 via a non-cleavable linker containing N-succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC), an ADC (T-DM1, Kadcyla) authorized by the FDA in ...
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Israeli artificial pancreas may one day cure diabetes
The Engineered Micro Pancreas from Betalin Therapeutics is heading closer to clinical trials in humans. Ahead of International Diabetes Day, November 14, Israeli startup Betalin Therapeutics announced that it is beginning the application process for clinical trials of its revolutionary artificial pancreas. Betalin’s Engineered Micro Pancreas (EMP) aims to free patients suffering from the ...
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LimFlow Percutaneous Deep Venous Arterialization
What interested you in LimFlow, and how did you get involved in the PROMISE I trial? Dr. Clair: Practicing vascular surgery, where a number of patients are evaluated for chronic limb-threatening ischemia (CLTI), you are guaranteed to have patients who are not candidates for percutaneous or surgical revascularization. These patients often have arterial systems open or identifiable to the ankle, ...
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A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices
Abstract Cardiovascular disease is the number one cause of death in the United States. Deployment of stents and vascular grafts has been a major therapeutic method for treatment. However, restenosis, incomplete endothelialization, and thrombosis hamper the long term clinical success. As a solution to meet these current challenges, we have developed a native endothelial ECM mimicking ...
By Endomimetics
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Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve central hemodynamics, ...
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