whole blood sample Articles
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PKU and MSUD screening for phenylketonuria and maple syrup urine disease
Phenylketonuria (PKU) and Maple syrup urine disease (MSUD), branched-chain ketoaciduria are genetically transmitted metabolic diseases. PKU results in elevated Phenylalanine levels due to deficient activity of the enzyme Phenylalanine hydroxylase. In the MSUD state, elevated levels of leucine (Leu), isoleucine (Ile), valine (Val), and alloiso-leucine can be detected in blood. The increased ...
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Performance Evaluation of the Coag-Sense Prothrombin Time (PT)/INR Monitoring System
Introduction Oral anticoagulant therapy (OAT) using warfarin (Coumadin) has surged in recent years due to an increased number of indications and its demonstrated effectiveness. The primary means of monitoring the response to warfarin is the Prothrombin Time (PT) test, which is measured in seconds. The increased use of OAT has led to the development of point-of-care (POC) portable monitoring ...
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Dependence of T-lymphocyte activation on the extent of cellular damage
Mechanically damaged cells release intracellular substances, resulting in the activation of CD4- and CD8-positive T-lymphocytes. The goal of this investigation was to quantify and compare fractions of activated CD4- and CD8-positive T-lymphocytes, based on the quantity of damaged cells in a given blood sample. Blood samples were mechanically stressed by vortexing intensely. Subsequently, ...
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