Matched tumor-normal sequencing: The preferred method for identifying somatic mutations driving tumorigenesis

Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty.

In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform prognosis. Despite the recognized value of tumor-only sequencing, labs performing this type of testing face a number of technical challenges that, if not properly addressed, can render the results uninformative or even misleading.