Polysaccharides Function as Backbone for Embryonic Osteogenesis

Osteogenesis, or new bone formation, begins in the early stages of embryonic development and continues postnatally until skeletal maturity is reached in early adulthood. Osteogenesis reoccurs in the event of bone trauma, such as a fracture or surgically created defect. Bone mass can also increase in response to chronic weight bearing from daily use or decrease due to a lack of movement or applied force, further illustrating the dynamic nature of bone tissue. A closer look at the biological processes that drive osteogenesis, particularly in the embryonic environment, can provide insights into the mechanisms of normal bone remodeling and clinically-assisted bone regeneration.