The Advantages of Exenatide Microneedle Patch Preparation Technology

The backing layer is prepared with the same polymer solution as the needle tip, and polyvinyl alcohol is used as the backing film-forming material to support the microneedle fractions, so that the backing layer has a tight bond with the microneedle tip, and the backing film and the needle tip can be consistently detached from the mold when the film is uncovered, without the problem of process interruption of the needle.

The selection of hyaluronic acid, which improves the swelling capacity of the prescription and increases the speed of drug release and transdermal absorption efficiency.
The use of hydrophobic mold material to prepare microneedles maintains the integrity of the needle shape and the uniformity of drug loading.

Full analytical testing of microneedles include: morphology testing, swelling analysis, drug release assays, etc.

Exenatide microneedle morphology analysis
The prepared microneedles are observed under microscope and photographed, and the surface morphology of the microneedles is observed more clearly by Scanning Electron Microscope (SEM).

Microneedle unmolding ease examination
The ease of microneedle unmolding can be observed by adjusting the ratio of polymer and exenatide, and designing different prescription ratios to see whether the prescription is conducive to microneedle forming.

Exenatide microneedle patch swelling analysis
The analysis was performed by putting the wrapped microneedle tablets into water and immersing the needle tips into the water to perform the swelling experiment. The microneedle tablets were removed at different times, the water was aspirated from the microneedle tablets, the weight of the microneedle tablets was weighed, and the data was recorded. Graphs were made to examine the degree of swelling and the rate of swelling of the microneedle tablets.