The Significance of Post-Translational Modification in Pharmaceutical Industry
Post-translational modification (PTM) is the covalent and generally enzymatic modification of proteins following protein biosynthesis. PTMs can alter the physicochemical properties of the peptide by changing the electrostatic charge, hydrophilicity, and conformation, thereby modulating their ability to specifically bind to the protein of interest. And PTM can also regulate protein folding, target specific subcellular compartments, interact with ligands or other proteins. As a result, the analysis of proteins and peptides and their post-translational modifications is particularly important for the study of diseases where multiple genes are known to be involved, such as heart disease, cancer, and diabetes.
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