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Case Reports in Pancreatic Cancer is an open access journal delivering authoritative case reports on all aspects of pancreatic cancer diagnosis, management, treatment, and outcomes. ...
The events that contribute to the expansion of beta-cell mass and enhanced beta-cell function in insulin-resistant states have not been elucidated fully. Recently, we showed that beta-cell adaptation failed dramatically in adult, insulin-resistant POKO mice, which contrasts with the appropriate expansion of beta cells in their ob/ob littermates. Thus, we hypothesised that characterisation of the ...