Clinical Medicine Articles
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Algae toxins linked to brain diseases found in Florida
An innovative field study in Southwest Florida has identified several neurotoxins in the state’s air and water. The three forms of BMAA – beta-Methylamino-L-alanine – are associated with brain diseases. The study conducted by Calusa Waterkeeper volunteers and analysed by Wyoming’s Brain Chemistry Labs identified two forms of BMAA in every sample from 945 completed over ...
By LG Sonic
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Mitochondrial Proteomics
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. ...
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Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit - Case study
Objective: To reduce exposure to hyperoxia and its associated morbidities in preterm neonates. Study design: A multidisciplinary group was established to evaluate oxygen exposure in our neonatal intensive care unit. Infants were assigned target saturation ranges and signal extraction technology implemented to temporally quantify achievement of these ranges. The outcomes bronchopulmonary ...
By Masimo Corp
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Pulse Oximetry with Clinical Assessment to Screen for Congenital Heart Disease in Neonates in China: A Prospective Study - Case study
Background Several pioneering studies have provided evidence for the introduction of universal pulse oximetry screening for critical congenital heart disease. I lowever, whether the benefits of screening reported in studies from high-income countries would translate with similar success to low-income countries is unknown. We assessed the feasibility and reliability of pulse oximetry plus clinical ...
By Masimo Corp
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Accuracy of Pulse Oximeters Intended for Hypoxemic Pediatric Patients - Case study
OBJECTIVES: Prior studies have shown inaccuracies in pulse oximetry readings at saturations less than 85%; however, no large studies have evaluated new sensors marketed for these low saturations. This study's purpose was to evaluate two sensors with claims of improved accuracy in children with saturations less than 85%. DESIGN: Prospective observational study. SETTING: Single institution; ...
By Masimo Corp
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Luminex Multiplex Assay
Principle of Luminex Multiplex Assay Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test ...
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Research Shows a Link Between Loneliness and Dementia
Humans are inherently social beings who thrive on making and maintaining social relationships. Connecting with and supporting one another forms deep bonds that make us feel seen, valued, and like we belong. These social interactions are not only important for our emotional well-being but also for our physical well-being-maybe even more so than originally thought. Loneliness, an increasingly ...
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Transcutaneous Magnetic Stimulation (tMS) in Alleviating Post-Traumatic Peripheral Neuropathic Pain States - Case Study
Abstract Background. Peripheral nerve injury can result in the formation of neuroma/nerve entrapment, a persistent peripheral neuropathic pain state which is often refractory to invasive interventions or medications. Therefore, there is a need in the field of pain management to develop innovative noninvasive therapy in treating post-traumatic peripheral neuropathic pain states. A new ...
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OneThree`s Workflow for Target and Compound Discovery - Case study
Background OneThree Biotech was born out of the largest precision medicine institute in America with the purpose of decreasing the failure rate of bringing therapeutics to market using biology driven artificial intelligence. Our technology was builtin a lab setting; allowing us to engineer our methodologies around real-world results. While working with major biotech and pharma partners; ...
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OneThree’s Workflow for Identifying Synergistic Drug Combinations - Case study
Background OneThree Biotech was born out of the largest precision medicine institute in America with the purpose of decreasing the failure rate of bringing therapeutics to market using biology driven artificial intelligence. Our technology was builtin a lab setting; allowing us to engineer our methodologies around real-world results. While working with major biotech and pharma partners; ...
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OneThree`s Workflow for Predicting Drug Toxicity - Case study
Background OneThree Biotech was born out of the largest precision medicine institute in America with the purpose of decreasing the failure rate of bringing therapeutics to market using biology driven artificial intelligence. Our technology was builtin a lab setting; allowing us to engineer our methodologies around real-world results. While working with major biotech and pharma partners; ...
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Effect of Low FrequencyTranscutaneous Magnetic Stimulation on Sensory and Motor Transmission - Case Study
INTRODUCTION After a peripheral nerve injury, fast conducting large myelinated afferent A-bcta fiber transmission diminishes over time. On the other hand, firing of smaller pain transmitting fibers such as A-dclta and C-fibcrs is enhanced. This aberrant afferent neuronal behavior is thought to be one of the main neuronal mechanisms leading to development of chronic posttraumatic peripheral ...
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The Parasym Device? Significantly Increases Parasympathetic Activity?
Autonomic Balance The parasympathetic nervous system (PNS) and sympathetic nervous system (SNS) both work in balance and together make up the autonomic nervous system (ANS), which is responsible for many of the bodies autonomic (unconscious) processes. The parasympathetic system has been referred to as 'rest and digest' and the sympathetic system to that of 'fight or flight'. Activating the PNS ...
By Parasym Ltd.
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The Vagus Nerve - What is it and why is it so important to our health?
Key points The vagus nerve controls many unconscious processes in the body The vagus neural network interfaces with inflammatory, mood and pain regulation. This can be utilised for its neuromodulatory effect in activating restorative pathways. The vagus nerve has been called the ‘great wandering protector’ of the body, it’s made up of an intricate neural network that ...
By Parasym Ltd.
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Transcutaneous Vagus Nerve Stimulation (tVNS) Enhances Divergent Thinking
Highlights of Research A clinical study investigated transcutaneous vagus nerve stimulation (tVNS). Results indicate tVNS stimulates afferent fibers of the vagus nerve; and, that tVNS enhances creativity performance in divergent thinking. Divergent thinking is a thought process or methodology that is used to generate creative ideas by exploring a number of possible solutions to a problem. ...
By Parasym Ltd.
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The Benefits of Decentralized Clinical Trials for Neurology
The COVID-19 pandemic has catalyzed the implementation of decentralized clinical trials in neurology, bringing the immense benefits of clinical trials to light. This industry-wide push towards trial decentralization has emerged as a key element for improving clinical trial efficiency and improving the experience for patients and physicians. By utilizing digital technologies, such as wearables, ...
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New Research Shows tVNS deactivates Tinnitus related brain regions ?
From the ear to the brain Tinnitus is a condition where one hears or perceives a sound without any external sound stimulus, it is commonly experienced as a high pitched ringing or buzzing. As tinnitus is experienced as a phantom sound it was initially thought to arise from the ear, however, recent research has shown that perception and generation are often linked to specific brain regions. A ...
By Parasym Ltd.
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Mood enhancement and Neural Network Modulation with Transcutaneous Vagus Nerve Stimulation (tVNS)?
Depression and the vagus nerve Depression affects millions of people worldwide and constitutes a leading cause of disability. Although pharmacological interventions are available, many of them produce suboptimal outcomes due to high non-responsive rates or intolerable side effects. It has been estimated that between 20 to 40 per cent of patients either failed to respond to conventional ...
By Parasym Ltd.
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Can We Predict Treatment Success in tVNS?
Predicting Treatment Success Transcutaneous vagus nerve stimulation (tVNS) has recently emerged as a promising treatment for depression and an effective mood enhancer, showing benefits over similar treatments including traditional vagus nerve stimulation (VNS) which is invasive and costly. tVNS targets the auricular branch of the vagus nerve and works by applying a small electrical stimulation ...
By Parasym Ltd.
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Vagus Nerve Stimulation
Disambiguation The process of stimulating the Vagus Nerve with micropulses of electrical current is referred to in a number of different ways. Vagus Nerve Stimulation (VNS) - Typically refers to stimulation of the nerve with a surgically implanted device and electrode. Non-invasive Vagus Nerve Stimulation (tVNS, taVNS, nVNS, LLTS) - Refers to stimulation of the vagus nerve without ...
By Parasym Ltd.
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