Clinical Medicine Articles
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Karyotype Analysis for Rare Disease
Karyotype analysis refers to the pairing and grouping of chromosomes to reveal whether the organism accords with the inherent chromosomal characteristics, to determine if the organism has chromosomal abnormalities. Karyotype analysis can detect whether there are abnormalities in chromatin length, centromere position, the ratio of long and short arms, and the presence or absence of satellites. ...
By Protheragen
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Evaluation of Anti-Stroke Drugs
Stroke, also known as transient ischemic attack or cerebrovascular accident, is an acute brain disease. Usually, a sudden rupture of a blood vessel in the brain or a blockage of a blood vessel that prevents blood from flowing to the brain can cause damage to brain tissue, resulting in a stroke. Long-term strokes can lead to brain damage, disability and even death. The brain serves as a ...
By Protheragen
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RNA-targeted Gene Therapy
In recent years, various nucleic acid-based therapies (NBT) have emerged as effective and specific activators of endogenous gene expression. Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and ...
By BOC Sciences
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Comparison and Analysis of SMDC, ADC, and DAC
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. What are their similarities and differences? What are their respective advantages? What is the current status of ...
By BOC Sciences
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The Difference Between Span 60 and Tween 60
Span 60 Span 60 is referred to as S60, its main chemical composition is dehydrated sorbitol stearate, the appearance is yellowish waxy solid. Span 60 is an excellent oil-in-water emulsifier with wetting and diffusion properties. It can also be used as a fiber post-processing softener to eliminate static electricity on the fiber to improve softness. Span 60 is harmless to the human body, so it is ...
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Electrospinning Technology of Recombinant Human Collagen
Electrospinning can produce continuous fibers on the micro - and nano-scale. The high flexibility and low cost of the material make electrospinning very attractive. In addition, the high specific surface area, porosity, and similarity to ECM ensure that the electrostatic pad promotes cell adhesion, skin regeneration, nutrient and oxygen transport, moisture retention, exudate removal, and ...
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Food Nutrition Enhancers
Food nutrition enhancer, also called food nutritional fortifier, refers to natural or synthetic nutrients added to food in order to increase its nutritional content. It can not only supplements people's daily nutritional intake, but also has a positive effect on disease prevention and control. The food nutrition enhancers can be divided into four main categories as following. Vitamins Vitamins ...
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Classification of Excipients for Transdermal Drug Delivery System
Transdermal drug delivery system is a type of drug formulation that is absorbed into the body circulation through capillaries at a certain rate through the skin to produce drug effects. Transdermal drug delivery systems allow the drug to continuously diffuse through the skin, penetrate and absorb into the blood circulation, maintain stable blood concentrations for a long time, reduce the ...
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Nanoparticle Development: Revolutionizing Drug Delivery Systems
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific ...
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In Vivo Biotin Recombinant Antibodies
Yeast produces biotinylated recombinant antibodies in vivo. Researchers have now developed a new method to generate in vivo biotinylated recombinant antibodies secreted by yeast. In vivo biotinylation supports efficient biotinylation for accurate testing. Yeast is a single-celled fungal organism that has played an important role in the field of biogenetics in recent years. Based on the expansion ...
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NEBS and PIEZO2: Guardians of the Respiratory Galaxy
In a recent Nature publication by Schappe,M (2024), researchers have revealed a fascinating aspect of respiratory physiology: the role of sensory neurons in guarding against airway obstruction and orchestrating crucial reflexes to maintain respiratory function. The study explores the intricate neural pathways involved in detecting and responding to airway closure. By characterizing a ...
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Understanding the Different Levels of CPR Training
CPR training is more than just a certification; it’s a crucial skill that can save lives in critical situations. In Kentucky, where industries range from manufacturing to healthcare, the demand for comprehensive CPR and first aid training is ever-present. The different levels of CPR training are designed to meet specific needs – from basic techniques for laypersons to advanced ...
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6 Steps To Getting A CPR Certification In Kentucky
In Kentucky, the significance of CPR certification extends far beyond a mere qualification. It’s about empowering individuals with the ability to make a crucial difference during emergencies. Each year, situations arise where immediate and knowledgeable action is essential. Being trained in CPR means not only responding to a crisis but doing so with the proficiency and confidence that can ...
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How to Apply In Vitro DMPK Services to Support Drug Development and ADMET Study
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...
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A Closer Look at Reporter Lentiviral Particles: Tool for Biomedical Research
Introduction For years, scientists have leveraged the brilliant potentialities of genetic science to explore how cells function and interact in living organisms. Among the numerous tools employed are "reporter systems," which use a visible marker to track gene expression, protein interactions, and other vital biological processes. One such system employs reporter lentiviral particles, using the ...
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Unleashing the Potential of Bacterial Genome Editing: A Gateway to the Future
Technological advancements and innovative research have continuously led to the discovery and development of new methodologies in the field of biological and medical sciences. One such breakthrough discovery is bacterial genome editing, which opens a new world of opportunities and challenges in the field of biotechnology and genomics. Understanding Bacterial Genome Editing Bacterial genome ...
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Unveiling the Potential of Premade RNA-LNP Products
Introduction RNA Lipid Nanoparticles (LNP) technology has rapidly gained prominence in the health and scientific domain, primarily due to its significant role in carrying the mRNA of the COVID-19 vaccines developed by Pfizer/BioNTech and Moderna. Yet, the potential of this technology spans beyond the confines of these vaccines or even the health industry. As research into premade RNA-LNP products ...
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Unleashing the Potential of Recombinant Adeno-Associated Virus (rAAV) Particles in Gene Therapy
Recombinase Adeno-Associated Virus (rAAV) particles have taken the center-stage in gene therapy research and development due to their exceptional genetic manipulation capabilities, safety and unprecedented therapeutic success. As biomedical science advances, there is an ever-increasing enthusiasm in the usage of rAAV particles as effective vehicles for gene delivery and the subsequent therapy. ...
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CpG Oligodeoxynucleotides Synthesis
Creative Biogene is one of the leading biotechnology companies which has the expertise and ability in providing CpG oligodeoxynucleotides synthesis service for customers worldwide. Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to assist you synthesis your interested CpG oligodeoxynucleotides. Creative Biogene's goal is to provide ...
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An In-depth Analysis of hERG (IKr, Kv11.1): Its Function, Role, and Importance
Introduction hERG, which stands shorthand for the human Ether-à-go-go-Related Gene, generates the protein responsible for a certain type of potassium channel in the human heart, denoted as IKr or Kv11.1. The role of this potassium channel is fundamental for normal cardiac function, playing a vital role in the termination of the cardiac action potential and ultimately contributing to the ...
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