Clinical Medicine Articles
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CMC Regulatory Considerations for ADCs
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs have been approved worldwide, of which the FDA has approved 13 ADCs for various cancers, including Adcetris®, Kadcyla®, Besponsa®, Mylotarg®, Lumoxiti®, Polivy®, Padcev®, Enhertu ®, Trodelvy® and Blenrep®. As ...
By BOC Sciences
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Antibody-Drug Conjugates: New Strategies of ADC Payloads
The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to be used to produce monoclonal antibodies, that the era of ADC drug development truly began. Driven by increasingly mature technology, ADC drugs have gone through three iterations (Fig. 1). Although ADCs have gone through three iterations, current ...
By BOC Sciences
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CSX-1004: A Promising Canidate in the Fight Against the Fentanyl Crisis
The opioid crisis in the United States is a devastating public health issue, with over 70,000 overdose deaths annually, largely driven by the highly potent synthetic opioid fentanyl. The urgency to address this crisis has spurred the development of innovative therapies to prevent and reverse fentanyl overdoses. In this blog, we will explore the groundbreaking preclinical work on CSX-1004, a fully ...
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Best Wound Care Kits & Solutions for Seniors
Each wound tells a unique life story, whether it's from a sudden accident or a chronic condition. Wound care is important, especially for the elderly. Giving them only love and care is far from enough, but you also need to learn how to effectively manage different types of wounds. In this article, we will discuss the best senior wound care solutions, quality senior care products, and provide ...
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Wound Care Nurse Teaching:DOs and DON'Ts for Wounds Healing
Introduction Nursing the wounds is something we all need to think about, whether it's dealing with a little cut from a DIY project at home, a tumble outdoors, or a surgical procedure. And as the body get age, the skin wounds become more frequent. It's time to understand the advantage wound care for for optimal healing. This article offersexpert-approved advice to help you manage different types ...
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Speeding Up Healthcare Innovation Leveraging Cloud Technology
Over the past decade, cloud computing has undergone remarkable expansion. The collective revenue generated by AWS, Google Cloud, and Microsoft surged from $49 billion in 2018 to an astonishing $206 billion in 2022.[i] Projections from Future Market Insights indicate that the revenue from cloud services is poised to maintain an impressive average annual growth rate of 21%, reaching a staggering ...
By Caresyntax
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Stay Safe Every Day: Child Choking Insights
As we highlight Safety Month this September, let us remember that safety is not just a one-month thing, but a daily commitment. Today let’s dive into a key aspect of safety: child safety. Did you know that more than 12,000 children in the United States are sent to emergency rooms each year due to food-related choking incidents? Even more heartbreakingly, at least three children around the ...
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Bile Acid: A Comprehensive Exploration of Function and Metabolism
In the realm of biological sciences, bile acids stand as pivotal molecules, playing a multifaceted role in various physiological processes within organisms. Bile acids are specialized molecules synthesized from cholesterol within the liver. These amphipathic compounds possess a hydrophilic region (carboxylic acid moiety) and a hydrophobic region (steroid backbone). Their distinctive structure ...
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Protein Engineering: Designing Molecular Machines for a Healthier Future
Proteins are the workhorses of life, performing a vast array of essential functions, from catalyzing biochemical reactions to building and maintaining cellular structures. Protein engineering, a rapidly evolving field at the intersection of biology, chemistry, and computer science, aims to harness the power of these molecular machines by designing and manipulating their structure and function to ...
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The Beginner's Guide to Exosome RNA-Seq
Exosomes are small extracellular vesicles that contain RNA, proteins, and lipids. These vesicles play a crucial role in intercellular communication and have been implicated in various physiological and pathological processes. Exosome RNA-Seq is a powerful technique that can be used to study the RNA content of exosomes and gain insight into their function and regulation. In this guide, we will ...
By CD Genomics
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Overview of Microbial Epigenetics
Introduction to Microbial Epigenetics Epigenetics has been defined as the study of stable alterations in gene expression potentials that arise during development and cell proliferation, or alterations in DNA function without alterations in DNA sequence. Modern epigenetic features refer to the alteration of DNA and/or associated proteins without nucleotide sequence variance, which transmits the ...
By CD Genomics
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How to Teach Children Emergency Wound Management Skills
In today's society, we pay special attention to the safety of children, however, accidental injuries are inevitable during their journey of exploring the world. Therefore educating children in first aid skills becomes critical. In this article, we take a closer look at why teaching children first aid skills is important to building safe families and communities, and how this can be achieved ...
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Application of Capillary Electrophoresis Technology in Biopharmaceuticals
Capillary Electrophoresis (CE) is an analytical technique used in the development and quality control of protein drugs. From medium optimization, clone screening, formulation stability research and purification process monitoring, to protein characterization, related impurity detection, protein structure identification and protein drug product quality control, CE is required in all aspects of ...
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Exploring the Intricate Link Between Bile Acids and Disease
Bile acids are synthesized in the liver from cholesterol as a raw material. As a natural "emulsifier", they can promote the dissolution, digestion and absorption of fats, fat-soluble vitamins, etc. Meanwhile, as an important signaling molecule, bile acids can activate the relevant receptors to maintain the homeostasis of hepatic glucose and lipid metabolism, and interact with gut bacteria to ...
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What Is Metabolomics?
Metabolism is the assembly of biochemical reactions in living organisms, the material basis for life maintenance of living organisms, and an important basis for the study of life activities. Metabolomics studies the endogenous metabolic activities of life under the influence of the internal and external environments, including the detection and analysis of metabolite types and quantities and ...
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Senvok: Adventures Secured, Active Boys Thriving
Senvok's emergency wound closure device plays a crucial role in home first aid, ensuring that the daily exploration and adventures of your active boys are not only thrilling but also safe. Challenges of Family Adventures: In the dynamic household of an active boy, each day unfolds as an adventure. The morning sun awakens his curiosity, leading him to explore the backyard, aspire to be the ...
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Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
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Application of Flow Cytometry in the Pharmaceutical Industry
Flow cytometry (FC) is an important tool for analyzing complex pathways and responses of single cells, which can track cell phenotypes and functions in multiple dimensions. It is also increasingly applied in drug development. FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or ...
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Your Guide to Stock Your Wound Care Kit
Effective wound care with the help of a fully equipped wound care kit is very important both in the hospital and at home. The ability to respond quickly and efficiently to injuries is critical not only to impact a patient's recovery but also to prevent complications and potentially save lives. Whether in a medical setting or in everyday life, having a well-equipped wound care kit is critical for ...
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Carbohydrate Synthesis: The Art of Building Sugars
Carbohydrates, the ubiquitous energy source for life, are intricate molecules that play a fundamental role in various biological processes. Their synthesis is a testament to nature's ingenuity. Carbohydrate synthesis, a subfield of organic chemistry, delves into the intricate methods of constructing these essential molecules. It encompasses a wide spectrum of techniques, from the simple ...
By CD BioGlyco.
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