Cryotherapy Articles
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Pooled Human Cryopreserved Hepatocytes
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties of the liver, researchers can evaluate the ...
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Establishment of a Stable Organoid Culture System: Customization and Standardization
Prefix Organoids are miniature organs created in vitro from adult stem cells (ASCs) or pluripotent stem cells (PSCs). They form three-dimensional (3D) tissue-like structures through the self-organization, self-renewal, and differentiation capabilities of stem cells. Compared to traditional two-dimensional (2D) cell cultures or spheroids, organoids closely resemble living organs in terms of ...
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Biorepository Safety
What is a Biorepository? A biorepository, or "biobank", is a specialized facility designed to store, archive, and distribute biological samples for research or clinical purposes. Biorepositories house biological samples, such as blood, plasma, urine, saliva, tissues, DNA, and organs, among other specimen types, collected from consenting individuals. Critical associated information, including ...
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SmartFreezer®: Meeting the Medical Device Directive for Safe Sample Management
Medical devices are an essential component of healthcare, and they have significantly improved the quality of life for many patients worldwide. These devices may be categorised by their intended use and range from simple non-invasive items to fully implantable devices. The Medical Device Directive 93/42/EEC (MDD) is a regulation that sets out the essential requirements that medical devices must ...
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Blood Storage and Preservation
How Is Blood Stored and Preserved? Blood storage is an important process in the blood banking industry as it helps maintain the quality of blood and its medical effectiveness. Blood can be stored in a few different ways, but the most common method is refrigeration.Blood banks depend on donors to provide blood and blood components. When blood is collected from a donor, it must be processed to ...
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What is a Liquid Nitrogen Storage Tank and What is it Used for?
A liquid nitrogen (LN2) storage tank is typically a multi walled vessel which features a high vacuum between the walls to provide excellent thermal insulation. Such vessels are often used in cold chain storage and transport applications. When the vessel is used to store or transport cryogenic liquids (such as liquid nitrogen or liquid helium) only, then the vessel is known as a liquid nitrogen ...
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Cryopreservation Process, Methods and Storage Solution Explored
The Cryopreservation Process The Cryopreservation Process is where biological matter (cells, tissue, organs, etc) is preserved by cooling to a very low temperature. This process stops the normal cell functions and holds the sample in suspended animation. When the time comes to thaw the sample, normal biological function resumes.Cryopreservation Process Steps The cryopreservation process can be ...
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What is Cryogenic Storage?
What is Cryo Storage?Cryogenic Storage refers to the storage of Cryogenic liquids, which are used for their low temperature properties. Cryogenic liquids are extremely cold, with boiling points below -150°C. Such liquids include, liquid helium (-269°C), liquid hydrogen (-253°C) and liquid nitrogen (-196°C), which is the most widely used cryogenic liquid.There are two types of storage equipment ...
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Going beneath the surface of skin cancer - Case study
Summary In this Cell Patterns publication, Ozette co-founders and collaborators at the Cancer Immunotherapy Trials Network (CITN) outline a novel method of analysis of single cell data, FAUST, and validate the multiple potential applications. The paper tackles 2 important problems: 1) analysis of complex single cell datasets; 2) prediction of response to immunotherapy in cancer. Manual ...
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Q&A with Flyn McKinnirey, R&D Manager at Regeneus
Q. What is your background and experience in the regenerative medicine and stem cell space? How did this lead you to Regeneus? A. I’d always had a love for medical research, however found myself working in the pharmaceutical industry after university prior to joining Regeneus. After 6 years in the pharma industry, I’d decided I needed to get back to a research focused career. The ...
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Surgical management of an infected external iliac artery interposition graft with a bioengineered human acellular vessel
ABSTRACT Infection of prosthetic vascular grafts can manifest as pain, pseudoaneurysms, or arterial insufficiency in the leg. We present the case of a female patient with a medical history of a right external iliac artery endofibrosis, with a persistently infected synthetic iliofemoral bypass graft, which we replaced with a bioengineered human acellular vessel. At the 12-month follow-up visit, ...
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SEY and Other Material Properties Studies at Cryogenic Temperatures
Abstract A very low secondary electron yield is confirmed to be the fingerprint of laser treated copper substrates. In future high energy particle accelerators, this feature offers unquestionable advantages for electron cloud mitigation purposes. Thermal programmed desorption between 20 and 70 K by dosing Ar multilayers of different thicknesses on a laser treated copper substrate and on its flat ...
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Keeping Your Business Compliant with FDA’s UDI Regulations
The US Food and Drug Administration (FDA) requires that all medical devices are identified with a unique device identifier (UDI), in both human and machine-readable forms. These UDI regulations were put in place to enable healthcare providers and manufacturers to more quickly identify flawed devices, leading to faster recalls, and a reduction in medical errors. UDI regulations UDIs are unique ...
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Cryogenic Gate Valve
Description of Cryogenic Gate Valve: The main material of ZECO cryogenic gate valve is selected. Considering from the metallographic aspect, in addition to austenitic steel, copper and aluminum with face centered cubic lattice, general steel will appear low temperature brittleness at low temperature, thus reducing the strength and service life of the valve. When the temperature is higher than ...
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IVF Cryopreservation and Safe Handling Practices
Couples that want to have a baby but have not been able to conceive naturally are drawn to invitro fertilization (IVF) treatments. In an IVF treatment, several eggs are fertilized at once, which creates multiple embryos. While more than one embryo may be implanted, to spur the odds of pregnancy, there are inevitably some unused embryos. The remaining embryos may be preserved cryogenically, for ...
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