Human Disease Articles
-
Preclinical Animal Models as A Resource to Explore Rare Diseases
Rare diseases, also known as orphan diseases, are a diverse group of disorders that affect a small percentage of the population. Due to their low prevalence and limited understanding, treating and finding cures for these conditions present significant challenges. However, preclinical animal models have emerged as invaluable resources for advancing research and unraveling the mysteries surrounding ...
By Protheragen
-
Overview of Microbial Epigenetics
Introduction to Microbial Epigenetics Epigenetics has been defined as the study of stable alterations in gene expression potentials that arise during development and cell proliferation, or alterations in DNA function without alterations in DNA sequence. Modern epigenetic features refer to the alteration of DNA and/or associated proteins without nucleotide sequence variance, which transmits the ...
By CD Genomics
-
Examining Models of Chronic Obstructive Pulmonary Disease (COPD) and their Application in Other Disease Frameworks
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
-
Examining Models of Chronic Obstructive Pulmonary Disease (COPD) and their Application in Other Disease Frameworks
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
-
Single-Cell RNA Sequencing in Drug Discovery and Development
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to a better understanding ...
By CD Genomics
-
Why need animal cognitive behavioral tests?
1. Understanding animal behavior: Animal cognitive behavioral tests help researchers gain insight into how animals think, learn, and solve problems. By conducting cognitive behavioral tests, scientists can better understand the cognitive abilities of different animal species and how they compare to humans. 2. Comparative studies: Comparative cognition research is important for understanding the ...
By Protheragen
-
Amplicon Sequencing Technology Unveils the Enigmas of Microbial Populations
Amplicon sequencing is a cutting-edge technique that involves sequencing PCR products or captured fragments of specific lengths, enabling the analysis of sequence variations. Among the diverse applications of this technology, the 16S rRNA gene has emerged as a fundamental tool for sequence-based bacterial analysis, boasting decades of significance. The process of 16S/18S/ITS amplicon sequencing ...
By CD Genomics
-
Prokaryotic Microorganisms and Research Methods: Exploring the Tiny World
Introduction: Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucleus. Instead, it is located in a region of the cell known as the nucleoid. Additionally, prokaryotes possess another DNA-containing ...
By CD Genomics
-
Exploring the Potential of RNA-Seq in Various Fields
What is RNA-Seq? Regulation of gene expression is fundamental to linking genotypes with phenotypes. RNAs shape complex gene expression networks, which drive biological processes. An in-depth understanding of the underlying mechanisms of how to govern these complex gene expression networks is vital for the treatment of complex diseases such as cancer. Hybridization-based microarrays are used to ...
By CD Genomics
-
Evolutionary, Medical, and Clinical Applications of Whole Exome Sequencing
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases. The human genome contains approximately 3 billion base pairs of DNA. Among them, only about 30 ...
By CD Genomics
-
What is the ICD code for HFpEF?
Heart failure with preserved ejection fraction (HFpEF) is currently affecting over half of heart failure patients. The Centers for Medicare and Medicaid Services (CMS) and the National Center for Health Statistics (NCHS), two departments within the U.S. Federal Government’s Department of Health and Human Services (DHHS), use the International Classification of Diseases (ICD) for coding ...
-
Targeted Region Sequencing in Human Disease Studies and Clinical Care
Introduction to target region sequencing Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers to obtain whole genome or targeted regions of samples. Targeted region sequencing is preferred by ...
By CD Genomics
-
Exploring Amyotrophic Lateral Sclerosis (ALS) with PercayAI’s AI Tools
Welcome to our newest blog series where we investigate Amyotrophic Lateral Sclerosis (ALS) using our AI knowledge mapping tools. Check back for our next installment, in which we analyze transcriptomics from spinal cord samples collected from patients as well as a mouse model. In this post, we will continue to explore publicly available datasets surrounding Amyotrophic Lateral Sclerosis ...
By PercayAI
-
Protein Quantification Techniques and Their Application in Clinical Research
Representing the expression, post-translational modification, and protein-protein interaction for certain cells, tissues, or organs, proteomics has become an increasingly important means to understand the molecular mechanism and signal transduction of human disease and cancer. Protein levels in the body are in a steady state of equilibrium. Accumulation of proteins usually leads to qualitative ...
-
Applications of Microbial Whole Genome Sequencing
Microorganisms widely exist in nature and are closely related to human life and production. They are generally divided into fungi, actinomycetes, bacteria, spirulina, rickettsia, chlamydia, mycoplasma and viruses. Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. ...
By CD Genomics
-
The Development Process of DUBTAC
The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered “undruggable”, and several projects have entered clinical evaluation worldwide. Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer. ...
By BOC Sciences
-
Onchocerciasis Vaccine Research - Case Study
What is onchocerciasis? Onchocerciasis or river blindness is a human disease caused by the filarial worm Onchocerca volvulus, and it endangers approximately 120 million people each year globally. When the worms become adults, they can live for over a decade in knots ("nodules") under the skin and release millions of of smaller worms or microfilariae. Circulating microfilariae cause many clinical ...
-
Applications of Cell-penetrating Peptides
Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nano-size particles to small chemical compounds to large fragments of DNA. As a versatile peptide, CPP has been widely used for diagnostic and therapeutic applications. 1. Oligo and siRNA Transport As an important means for targeted therapy of specific genes, oligonucleotides ...
-
Mitochondrial Proteins
Mitochondria are dynamic organelles with bilayer membranes. Mitochondria have multiple functions, not only providing energy to cells through oxidative phosphorylation to produce ATP, but also involved in regulating processes such as calcium homeostasis, reactive oxygen species (ROS) production, cellular stress response and cell death. Mitochondria play a key role in maintaining cellular health ...
-
Key Takeaways from BIO 2022 for AI-enabled Drug Discovery
It was great to be back in person at the 2022 BIO International Convention this year. It came as no surprise to us at Recursion that artificial intelligence (AI) and machine learning (ML) were hot topics at the conference, with more than half a dozen sessions exploring how these technologies are driving digital transformation in biopharma. We heard from leaders who are applying AI at ...
By Recursion
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you