Immunodiagnostics Articles
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CD Biosciences Launches Substrate-Chromogens for Immunohistochemistry
CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the launch of its innovative line of Chromogenic Substrates for immunohistochemistry (IHC). These cutting-edge substrates offer superior signal sensitivity, long-term storage stability, enhanced safety, and user-friendliness, empowering researchers to unlock deeper insights into ...
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A Natural Polysaccharide-based Bioadhesive for Wound Repair Found
Hundreds of millions of people suffer skin tissue damage every year, including accidental injury, surgical injury, chronic ulcer, etc., and severe cases may lead to amputation or even life-threatening. Suturing is currently the preferred method for clinically closing wounds. However, wound suturing takes a long time during the operation, and removing the stitches will cause secondary damage to ...
By CD BioGlyco.
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Study of the pathogenic mechanisms of autoimmune myasthenia gravis - Case Study
Contexte Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies directed against components of the muscle membrane located at the neuromuscular junction. In the majority of cases, these are autoantibodies directed against the acetylcholine receptor (AChR). The origin of the autoimmune response is not known, but thymic abnormalities and defective regulation of the ...
By Inovarion
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Protein Identification by Tandem Mass Spectrometry
Methods in protein identification Protein identification here refers to the accurate screening and identification of proteins using certain biochemical and physical methods. Traditional protein identification methods, including immunoblotting, comigration analysis of known or unknown proteins, and chemical sequencing of endopeptides, are complicated, time-consuming, and less accurate. Protein ...
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Tips & Tricks to Optimize Your Tissue Processing
Since the 19th century, the practice of tissue processing has remained largely unchanged, resulting in solidified, paraffin-embedded tissue blocks for sectioning. As staining procedures have advanced and immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurate interpretation of disease ...
By Quartzy Inc.
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INOVIQ study validates the use of SubB2M as an aid in diagnosing malignant melanoma
Data from 144 tissue samples in the feasibility study demonstrated that SubB2M immunohistochemistry detected melanoma with 91% sensitivity and discriminated between malignant melanoma and benign skin lesions. SubB2M-based immunohistochemistry applications represent a new product opportunity for SubB2M in the $1.9b immunohistochemistry market. INOVIQ Ltd (ASX:IIQ) has successfully completed ...
By INOVIQ Ltd
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A Robust Computer-Aided Approach for Scoring and Quantitative Evaluation of Whole Slide Digital Images of HER2 Immunohistochemistry in Breast Cancer
HER2 is recognized as an essential prognostic parameter in breast cancer. Usually interpretation of HER2 negative cases which has no membrane staining or has faint and weak incomplete cells and also positive cases (3+) that consist of strong and complete cell are easy but cells with moderate and weak HER2 staining (2+ or equivocal) require further analysis with fluorescence in situ hybridization ...
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Bartonella ImmunoBlots Now Available!
The wait is over. Patients with a suspected Bartonella infection are now able to order the IGeneX ImmunoBlots. ImmunoBlots use recombinant antigens to increase sensitivity, specificity and extend species coverage. They effectively replace the Western blot. ImmunoBlots are already available for other diseases including Lyme and Tick-Borne Relapsing Fever (TBRF). We are very excited to now offer ...
By IGeneX
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Ovarian structure protein 1: A sensitive molecular biomarker of gonadal intersex in female Japanese medaka after androgen exposure
Intersex in gonochoristic fish can be induced after exposure to androgens and estrogens. The main objective of the present study was to identify biomarkers that would be predictive of intersex in Japanese medaka (Oryzias latipes) after exposure to synthetic hormones. First a gene was identified, ovarian structure protein 1 (osp1), with strong female‐specific expression during gonadal ...
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Characterization of an escherichia coli o157:h7 o-antigen deletion mutant and effect of the deletion on bacterial persistence in the mouse intestine and colonization at the bovine terminal rectal mucosa
Escherichia coli O157:H7 causes hemorrhagic colitis and the life-threatening hemolytic-uremic syndrome in humans and transiently colonizes healthy cattle at the terminal rectal mucosa. To investigate the role of the O antigen in persistence and colonization in the animal host, we generated an E. coli O157:H7 mutant defective in the synthesis of the lipopolysaccharide side chain (O antigen) by ...
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Induction of adipose tissue regeneration by chemically-modified hyaluronic acid
Hyaluronan was modified by amidation of the carboxyl groups with dodycyl amides to produce a viscous gel (HYADD3). Small aliquots were implanted intramuscularly in Wistar rats at a concentration of 30 mg/ml for up to 12 weeks. Standard histology and immunohistochemistry demonstrated low levels of inflammation at all time periods, absence of any fibrous capsule coupled with the presence of mature ...
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Envelope-based HIV vaccine peptides as antigens in HIV-1 immunodiagnostics
Many HIV-1 envelope-based synthetic peptides behave as antigenic mimics of linear or conformational epitopes generated in vivo in infected subjects, meaning they can be used as immunogens for antibody induction in appropriate animal models or as antigens in Enzyme-Linked Immunosorbent Assay (ELISA). These peptides are linear or branched, single sequenced or multi-epitopic, mostly representative ...
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