Articles
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Effect of Climate Change on Lyme Disease Risk in North America
An understanding of the influence of climate change on Ixodes scapularis, the main vector of Lyme disease in North America, is a fundamental component in assessing changes in the spatial distribution of human risk for the disease. We used a climate suitability model of I. scapularis to examine the potential effects of global climate change on future Lyme disease risk in North America. A ...
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Hybrid buildings: a pathway to carbon neutral housing
In the residential sector, there is growing interest in the concept of carbon neutral and net zero energy housing within the context of emerging climate change mitigation and energy security strategies. A hybrid building represents a new class of dwelling capable of achieving net zero energy, carbon neutral or zero carbon status. This article reports on the carbon footprints of alternative ...
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A Synopsis of 30 Years of Major Accomplishments by the Pennsylvania Department of Health in Environmental Health (Part 2 of 2): The 1990s and the 21st
This article reviews significant environmental health projects conducted by the Pennsylvania Department of Health, particularly the Division of Environmental Health, during the 1990s and the following decade. The authors describe lessons learned from a new occupational health initiative, continuing work on the health assessment grant funded by the Agency for Toxic Substances and Disease Registry, ...
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Rejuvenessence by Light Sources, Inc. - A proven solution
With a host of top-notch red light units on the market and a body of proven science behind them, now is the time for salon owners to embrace adding red light therapy to their service menus! And lighting the way for this “red light revolution” is none other than veteran sunlamp maker, Light Sources, Inc. Light Sources, Inc. is the proud manufacturer of Rejuvenessence collagen ...
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NEW Rtx -BAC Plus 1 and Rtx -BAC Plus 2 Columns
Fast, Definitive Data for Blood Alcohol Testing Optimized column selectivities guarantee resolution of ethanol, internal standards, and frequently encountered interferences. Robust and reproducible column chemistry ensures longer column lifetime and accurate, consistent results. 2 minute analysis time increases lab productivity. New Rtx -BAC Plus 1 and Rtx -BAC Plus 2 columns from Restek ...
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The survival of mycobacteria in pure human urine
Mycobacterial pathogens can be excreted in human urine by some infected individuals. High numbers of pathogenic mycobacteria in the urine could represent a new transmission route for mycobacterial infections if the urine is used for crop fertilization. In this study, the survival of spiked Mycobacterium aurum and M. fortuitum as fast-growing mycobacteria and M. avium and M. bovis as ...
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Expert judgement and re-elicitation for prion disease risk uncertainties
Much uncertainty surrounds transmission of transmissible spongiform encephalopathies (TSEs) through blood and blood derived products. A first expert elicitation with 14 experts was conducted in March 2008, and a second re-elicitation involving 11 experts was held a year later in March 2009. Both expert groups were calibrated using a series of seed questions for which values are known, and then ...
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Managing virtual R&D organisations: lessons from the pharmaceutical industry
In this paper, the virtual organisation of R&D in Pharmaceuticals is studied. A virtual organisation in Research and Development is designed to access external knowledge and resources, necessary for generating and developing successful innovations. A survey has been conducted on nine pharmaceutical companies (from the USA, Europe and Japan), aimed to investigate the characteristics of Research ...
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TQM implementation barriers in academe: a framework for further investigation
Many academics and practitioners believe that Total Quality Management philosophy is the panacea of the 1990s for many industries in all segments of the economy, including education. Many others have argued that TQM is a fad, and like many of its predecessors, such as Management By Objectives (MBO), is going to fade away. Existing cases of successful implementation of TQM in business enterprises, ...
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Learning from users for radical innovation
Our study focuses on the question of what kinds of users are able to actively contribute to the development of radical innovations and what firms can learn from them to improve their innovative capability. A multiple case study analysis was conducted in the field of medical technology. The case study analysis reveals that users with a unique set of characteristics can contribute substantially to ...
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A relational model of medical knowledge sharing and medical decision-making quality
Knowledge sharing has been recognised as a key approach in sustaining a competitive advantage. In knowledge-intensive firms like healthcare organisations, expertise is based upon well-developed and reshapeable knowledge networks. Hence, it is believed that in healthcare organisations, knowledge sharing among physicians improves medical decision-making quality. We propose a relational model ...
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Molecular dynamics simulations of breaking metallic nanowires
In the present work, we have reviewed the importance of conductance histograms as an experimental tool able to address the statistical behaviour of the electronic transport through metallic nanowires. We have described how molecular dynamics techniques combined with embedded-atom method (EAM) are able to reproduce the general features noticed during metallic nanowire breaking experiments. We have ...
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First patient inclusion of the METAglut1 study
The METAglut1 study is a prospective study to validate the diagnostic performance of the METAglut1 test in patients clinically compatible with GLUT1 Glucose Deficiency Syndrome (GLUT1-DS) or « DE VIVO Disease ».It will be conducted in about 40 French centers and plans to include between 2500 and 3000 patients over a period of 30 months. This study has received the support of the ...
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Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study
Abstract Introduction. To compare the safety and efficacy of the Therapeutic Hyper-CL™ lens versus a standard bandage contact lens (PureVision B&L) for chronic corneal edema. Methods. Prospective, multicenter, randomized, crossover study. Chronic corneal edema patients were randomized to one of two arms. The first arm was fitted with the Therapeutic Hyper-CL™ lens while the ...
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Abstract 15053: New Insights into the Development of the Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists
Abstract Protease proprotein convertase subtilisin-like kexin type 9 (PCSK9) is an important target for the treatment of hypercholesterolemia. PCSK9 is synthesized as a zymogen that undergoes autocatalytic processing and secretion. Secreted PCSK9 binds to the LDL-receptor (LDLR) and chaperones it to the degradation pathway. Several pharmaceutical companies have developed injectable mAb PCSK9 ...
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3 ways VisualDx boosts my confidence and saves me time as a nurse practitioner
Imagine you’re sipping (okay, realistically, chugging) your caffeinated beverage of choice in the morning as you log into your computer to take a peek at your schedule. Now think about what appointment type is guaranteed to drop ice-cold dread right into the pit of your stomach, because we for sure all have one. Now, don’t get me wrong, the cool thing about working in primary ...
By VisualDx
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Rho kinase inhibition in Amyotrophic Lateral Sclerosis - Case Study
REAL is a phase 2a open-label study to assess preliminary safety, tolerability, and effect on clinical outcomes as well as neurodegeneration biomarkers of BRAVYL in patients with ALS. The study will enroll approximately 20 patients, all of whom will be treated with BRAVYL for 24 weeks. ...
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Microorganisms Fact Sheet: Definition, Types, and Importance
Microorganisms can be found everywhere, in the coldest or hottest environment, in the air, in water, in soil, in plants, and even inside the human body. These organisms have a big contribution to the ecosystem and to the biosphere as a whole. They have existed even before the earth was habitable for other organisms such as plants and animals. In fact, studies have shown that all organisms have ...
By CD Genomics
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The Importance of Organ Donation
Why should you donate organs? Organ donation is a way to save the lives of people who are sick, not healthy and in need of new organs. When someone’s organs are weak, they require a new one to continue living. Organ donation refers to the supply of a healthy organ, gained from either a living or passed away donor, to help an individual requiring a transplant to improve ...
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Exploring the Versatility of Tungsten Tubes in Industrial Applications
Welcome to the exciting world of tungsten tubes and their limitless potential in industrial applications. Tungsten, known for its exceptionally high melting point and durability, has been a staple material in various industries for decades now. However, it is often overlooked in comparison to other metals like steel or aluminum. In this blog post, we will delve into the versatility of tungsten ...
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