Intramuscular Administration Articles
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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A Difficult Needle to Thread
Do you know what it’s like to wake up in a different stranger’s house every morning? To open your eyes and immediately feel extremely uncomfortable, alarmed, unsafe, out of place, lost, dizzy, like your world is the most upside-down it’s ever been? Do you remember what it was like to be a kid tagging along to the grocery store with your parents? One second ...
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FluGen Announces First Subject Dosed in Phase 1b Clinical Trial of its Intranasal M2SR Flu Vaccine, Co-Administered with High Dose Vaccine, in Older Adults
Study will measure immune responses generated by M2SR and high dose vaccine separately and in combination in the highly vulnerable 65-85 years old population – Funded by the US Department of Defense, this study is expected to yield topline data in 2H 2022 – MADISON, Wis., June 22, 2022 /PRNewswire/ — FluGen, Inc., a clinical-stage vaccine company transforming vaccine ...
By FluGen, Inc.
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RVx201 Herpes Vaccine
RVx201 Herpes Vaccine Description 2022 RVx201 is a first-in-human herpes simplex virus type 2 (HSV-2) live-attenuated therapeutic vaccine modified to be interferon sensitive that destroys the ability of the virus to inhibit immune responses. Produced by Rational Vaccines, Inc., the technology is based on the pioneering research of the late Dr. William Halford, who dedicated over 25 years to ...
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Inhalation vaccine promises to be a powerful tool in the prevention and control of Omicron
Omicron, as the most transmissible variant of SARS-CoV-2, is rapidly spreading over the world and has displaced Delta as the dominant strain in a number of regions. Some experts have indicated that mucosal immunization of the respiratory system with an inhaled form of the vaccine may be more efficient in dealing with the Omicron strain in light of recent results that demonstrate Omicron ...
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FluGen Initiates NIH-Funded Trial of M2SR Flu Vaccine; First Study in Adults Up to Age 85
Study will measure immune responses to matched and drifted virus strains in older adults, a population that is most vulnerable to mortality from flu – Topline data expected in 1H 2022 – MADISON, Wis., May 25, 2021 /PRNewswire/ — FluGen, Inc., a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases, today announced the initiation of the ...
By FluGen, Inc.
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Micron developing microneedle technology for self-administration of vaccines and therapeutics
Closely-held Micron Biomedical is developing a dissolvable microneedle-based technology that could enable self-administration of vaccines and therapeutics. “While microneedle technology is not new, our company represents the evolution of the technology over many years,” Steven Damon, CEO, says in an interview with BioTuesdays.com. “We’re developing an innovative ...
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Your Herd Vaccinations May not Always be Successful? Why?
We hear a lot about how to protect yourself and others right now… and it is especially important to me because I am in a high-risk group (over 65 with underlining health conditions). In the Dairy Industry, we deal with high-risk groups every day–cows that have just calved and newborn calves less than 75 days of age. Herd immunity threshold (percent of animals that are immune) ...
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Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1 (F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
Abstract Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice against herpetic keratitis following ocular ...
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Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials
Abstract Background Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. Methods A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig model of genital herpes. Three doses of intramuscular (IM) vaccine were provided followed by ...
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