Microvascular Articles
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What is FGL2?
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
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What causes heart failure with preserved ejection fraction (HFpEF)?
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence of HFrEF from 44% ...
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Cellular and molecular differences between HFpEF and HFrEF
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
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Cercare Perfusion Reveals Microvascular Changes in COVID-19 - Case Study
Introduction Neurologic complications are frequently reported in COVID-19, but our understanding of their pathophysiologic causes and neuroanatomical correlates is limited. While several structural brain imaging findings have been reported in COVID-19, including non-spherical signal abnormalities on Susceptibility-Weighted Imaging (SWI), conventional perfusion imaging has not provided consistent ...
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Physiology and Pathology of Coronary Microcirculation
The heart is a unique organ in many respects since its activity is mandatory to sustain life. The heart’s circulatory system and coronary flow regulation are highly adapted to the vital role of the heart in sustaining life and to everyday physiological challenges. Understanding coronary physiology is key for treating patients with ischemic heart disease in general, and ...
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A Contemporary Review of ST-Elevation Myocardial Infarction: Pathophysiology, treatment options and hot topics
Pathophysiology, treatment options and hot topics Improvements In Stemi Treatment The immediate and long-term prognosis of patients experiencing an ST segment elevation myocardial infarction (STEMI) has changed dramatically since the introduction of coronary reperfusion therapies during primary percutaneous coronary intervention (pPCI). The evolution of these therapies accelerated with the ...
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Development of a Bioartificial Vascular Pancreas
Abstract Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased ...
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The evolution of photoplethysmography (PPG) within smart devices
As a technology, photoplethysmography (PPG) has been explored for almost a century, but it is only in the last few years that it has had a broader application beyond specialised medical settings. That has generally been driven by the evolution of smartphones, smartwatches and even smaller wearable devices such as smart rings. PPG is most commonly used in pulse oximetry in clinical settings ...
By Sky Labs
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3D Bioprinting Of Prevascularised Implants For The Repair Of Critically-Sized Bone Defects
By combining different cell populations in a fibrin bioink, researchers from Trinity College Dublin, Royal College of Surgeons in Ireland and University of Illinois Chicago were able to sprout an in vitro microvessel network that was then exploited to prevascularise a 3D printed scaffold implanted in a critical size femoral defect using REGENHU bioprinter. This dual approach was observed to ...
By Regenhu
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High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue
Highlights Deterministic barcoding in tissue enables NGS-based spatial multi-omics mapping DBiT-seq identified spatial patterning of major tissue types in mouse embryos Revealed retinal pigmented epithelium and microvascular endothelium at cellular level Direct integration with scRNA-seq data allows for rapid cell type identification Summary We present ...
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What is the meaning of neoplastic disease?
Neoplasia is the abnormal growth and proliferation of abnormal cells or abnormal amounts of cells due to a benign or malignant process. There can be benign tumors, or neoplasms, and malignant ones. Remember that it's the malignant tumors, or cancer, that can metastasize, which is when cancer spreads around the body. Leukemia is used for lymphoid neoplasms presenting with widespread involvement ...
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Microfluidic tools to investigate pathologies in the blood microcirculation
We show how microfluidics technology can be used to fabricate simple and innovative biomimetic tools to shed new light on physiopathological events occurring in the blood microcirculation. Examples of applications are given in the context of the acute respiratory distress syndrome (ARDS), an inflammatory disease of the lung triggered by a massive arrest of white blood cells in the lung ...
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Nanotechnology as a basis for the vascular treatment of atherosclerosis
It is now accepted that during the early stages of development of coronary and carotid atherosclerotic plaques, activation of vasa vasorum (VV) at specific sites in the adventitia initiates their proliferation or 'angiogenesis', and migration through the media into the intima of unstable developing lesions. Plaques regions containing these immature vessels tend to exhibit increased inflammation ...
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