Myocardial Health Articles
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Biotin PEG
What are Biotinylation and Biotinylated PEG?Biotinylation is the process of covalently attaching biotin to molecules (such as amino acids, peptides, antibodies, or proteins). Due to the small molecular weight of biotin, biotinylation is usually rapid and specific and is unlikely to interfere with the inherent function of the molecule. Biotin has extremely high affinity, rapidity and high ...
By BOC Sciences
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Unveiling The Manifold Potentials: Mesenchymal Stem Cells & Bone Marrow Mesenchymal Stem Cells
In the vibrant realm of cellular biology and regenerative medicine, mesenchymal stem cells (MSCs) hold unparalleled potential for therapeutic applications. Particularly noteworthy are bone marrow mesenchymal stem cells (BM-MSCs), a subtype of MSCs. Their unique properties make them indispensable resources for developing ground-breaking solutions for various medical conditions. Mesenchymal stem ...
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Unveiling the Role of CD73: A Key Player in Immune Regulation and Beyon
What is CD73? CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked ...
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Will Metformin Be Replaced By SGLT-2 Inhibitors
Metformin is a classic first-line hypoglycemic agent for patients with type 2 diabetes, and is an essential drug in combination regimenes. However, as the evidence is updated, the idea of drug selection for first-line treatment is changing. GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple ...
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Cellular and molecular differences between HFpEF and HFrEF
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
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What causes heart failure with preserved ejection fraction (HFpEF)?
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence of HFrEF from 44% ...
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What is the ICD code for HFpEF?
Heart failure with preserved ejection fraction (HFpEF) is currently affecting over half of heart failure patients. The Centers for Medicare and Medicaid Services (CMS) and the National Center for Health Statistics (NCHS), two departments within the U.S. Federal Government’s Department of Health and Human Services (DHHS), use the International Classification of Diseases (ICD) for coding ...
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Emerging therapy for HFpEF: SGLT2 inhibitors
Recent clinical trials investigating sodium-glucose cotransporter 2 inhibitors (SGLT2i) have highlighted that this drug is highly effective in treating patients with heart failure with preserved ejection fraction (HFpEF). HFpEF is a complex disease which accounts for more than half of all heart failure (HF) hospital admissions and is an increasing disease burden. [1] The prevalence of HFpEF is ...
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The latest developments of Medis QFR
December 2022 edition Given the regular posts of peer-reviewed scientific publications on the Medis QFR®, it is clear that this angio-based solution for coronary physiology is extensively used in clinical research and practice. We would like to share these publications with you so that you remain up to date about the research that is ongoing worldwide with this innovative solution, ...
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The Functions and Roles of Enzymes
Catalysis Enzymes are a class of biological catalysts. They govern many catalytic processes such as metabolism, nutrition, and energy conversion of organisms. Most of the reactions closely related to life processes are enzyme-catalyzed reactions. These properties of the enzyme enable the intricate process of material metabolism in the cell to proceed in an orderly manner, and to adapt material ...
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A Contemporary Review of ST-Elevation Myocardial Infarction: Pathophysiology, treatment options and hot topics
Pathophysiology, treatment options and hot topics Improvements In Stemi Treatment The immediate and long-term prognosis of patients experiencing an ST segment elevation myocardial infarction (STEMI) has changed dramatically since the introduction of coronary reperfusion therapies during primary percutaneous coronary intervention (pPCI). The evolution of these therapies accelerated with the ...
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Physiology and Pathology of Coronary Microcirculation
The heart is a unique organ in many respects since its activity is mandatory to sustain life. The heart’s circulatory system and coronary flow regulation are highly adapted to the vital role of the heart in sustaining life and to everyday physiological challenges. Understanding coronary physiology is key for treating patients with ischemic heart disease in general, and ...
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Efficacy and Detection of Ceramide
Ceramides are composed of sphingosine analogs and long-chain fatty acids bound by amide bonds, and are the most important of the sphingolipid compounds. Ceramide is synthesized and secreted by lamellar vesicles, which together with cholesterol (25%) and free fatty acids (15%) constitute the intercellular lipids (ceramide 50%) involved in maintaining the skin barrier function. It also has various ...
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What Are the Applications of Enzymes in Disease Research and Treatment?
With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive. 1. The relationship between enzymes and certain diseases The diseases caused by the lack of enzymes in the human body are mostly congenital or ...
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Huateng Pharma Supplies Canagliflozin Intermediates With Commercial Scale Production
Canagliflozin is a medication used to treat type 2 diabetes. It is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes. Mechanism action of Canagliflozin Canagliflozin is a sodium-glucose cotransporter (SGLT2) inhibitor. Glucose filtered in the renal tubular lumen is ...
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The Function and Application of the Magic Superoxide Dismutase
Some substances can easily interact with the oxygen in the air when exposed to the air, causing chemical changes in the substance. This is the process of oxidation. Sun exposure, air pollution, radiation, etc. will cause the human skin to produce a large amount of superoxide free radicals, and its strong oxidizing ability will accelerate the speed of skin oxidation, and may even cause serious ...
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How One Smart MedTech Company is Leveraging Innovation to Save the Lives and Limbs of VTE Patients
Medical device start-up companies must focus on innovation, regulatory compliance, efficient processes and prudent financial management in order to survive. Smart MedTech companies prioritize their funding to only support innovation which will result in new products that fulfill significant unmet clinical needs over the long-term. Thrombolex, a relatively new entrant into the MedTech sector, is a ...
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Force Myography to Control Robotic Upper Extremity Prostheses: A Feasibility Study
Advancement in assistive technology has led to the commercial availability of multi-dexterous robotic prostheses for the upper extremity. The relatively low performance of the currently used techniques to detect the intention of the user to control such advanced robotic prostheses, however, limits their use. This article explores the use of force myography (FMG) as a potential alternative to ...
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A Paradigm Shift in the Treatment of Venous Thromboembolic Disease
PE is the most common preventable cause of death among hospital patients in the United States. VTE is a leading cause of death and disability worldwide and has the third-highest mortality rate out of any cardiovascular disease, behind myocardial infarctions and stroke. Unlike myocardial infractions and stroke, where mortality has improved considerably, VTE has seen an increase in cases, with no ...
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VIC Portfolio Companies and Pipeline Technologies with Pandemic Impact
Our current daily activities bear little resemblance to the routines as of as recently as a month ago. COVID-19 has had an obvious and significant impact on the American people. For those suffering from chronic conditions such as dementia, diabetes, heart and respiratory disease, the health impact during traumatic periods such as this is magnified. The COVID-19 pandemic has disrupted our ...
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