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What’s a traumatic brain injury or TBI? The Centers for Disease Control and Prevention (CDC) defines it as an injury that disrupts how the brain works. TBIs can occur when the head receives a bump, jolt, blow, or is penetrated by an object (like a nail from a nail gun, a bullet, or a knife). The most common cause of a TBI is a fall. Injuries to the brain can also occur in car accidents, explosions, playing sports, assault, or being hit by an object. Concussions are considered as a milde