3 products found
Advanced Cellular Dynamics, Inc. (ADC) Products
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Primary & Transformed Cells Lines
There are 20,220 known genes in humans and the proteins they encode can be assembled into 950 different superfamilies (learn more). Within the cellular environment, these proteins interact with each other in complex ways that spatially and temporally regulate their activities. So, when it comes to profiling modifiers of protein function, all our assays are cell-based and constructed to measure the native activities of each protein.
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ACD - Immune Effector Cells
Our catalog of primary immune effector cells derive from whole blood obtained from anonymous donors. Individual subsets are affinity purified by negative selection when possible, or positive selection when necessary. The methods deployed are disclosed within the specification data so that you can decide if the process used might adversely impact the biology you wish to study. We deploy a variety of methodologies to evaluate subset functions. These include ...
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KinoScope & KinoCore
Most kinase inhibitors are ATP mimetics and thus share an overlapping space within the target protein where ATP binds. Specificity is achieved for individual drugs by adding chemical moieties that effectively extend into the various open spaces immediately surrounding the ATP-binding pocket. KinoScope and KinoCore use proprietary technologies to map and investigate this three-dimensional space.
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KinoScope - Kinase Inhibitors
A collection exceeding sixty commercially available kinase inhibitors have been tested for their ability to inhibit each of 62 kinases, which collectively represent more than two-thirds of the tyrosine kinome. The measured half-maximal inhibitory potentials were subsequently compared and used to construct a dendrogram representing a virtual map of the ATP binding pocket. The resulting KinoScope™ groups different kinases by virtue of these mapped ...
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KinoCore - Kinases Inhibitors
KinoScope™ parses kinases based on their spatial relationships surrounding the ATP-binding pocket, revealing eleven different subfamillies. Within each subfamily, we have selected a single kinase that captures the collective compound reactivities of the other members. We refer to the resulting panel of eleven assays as the KinoCore™ (highlighted in red). The power of this panel is that with only eleven cell-based assays, we can capture the ...