7 products found
Alfa Chemistry Products
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Boronic Compounds - Borate
Structurally, boronic acid compound is a trivalent boron-containing organic compound with alkyl substituent and hydroxyl groups to fill the valence on the boron atom. Due to the electron deficiency, the sp2-hybridized boron atom possesses an empty p-orbital. This low-energy orbital is orthogonal to three substituents. Unlike carboxylic acids and their carbon analogues, boronic acids do not exist in nature.
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Alfa - Model ACM1000160735 - Potassium Benzothiophene 3 Trifluoroborate
Product Name Potassium benzothiophene-3-trifluoroborate. CAS 1000160-73-5. IUPAC Name potassium;1-benzothiophen-3-yl(trifluoro)boranuide. Category Borate. Molecular Formula C8H5BF3KS. Molecular Weight ...
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Chemical Fluorescence Probe -Bodipy Dyes
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Alfa - Model ACM1021493786 - Bodipy Dyes
Product Name 1,7-(di-4-bromophenyl)-3,5-(di-4-methoxyphenyl)AZABODIPY. CAS 1021493-78-6. Category BODIPY dyes. Molecular Formula C34H24BBr2F2N3O2. Molecular Weight 715.20. Appearance Green ...
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Fluorinated Building Blocks -Heterocyclic Fluorinated Building Blocks
The history of fluorinated heterocycles can be traced back to the seminal work of Chichibabin who carried out the synthesis of 2-fluoropyridine over 90 years ago. However, real progress in this field did not gain momentum until about four decades later, in the 1950s, with the development of new synthetic methods and more readily-handled fluorinating agents. It was in this period that 5-fluorouracil can be prepared by a rational approach to new anti-cancer agents. The effectiveness of this drug heralds the development of many related anti-cancer agents that still have important clinical applications 50 years after the original discovery. Another major success story followed shortly thereafter with the discovery of the fluoroquinolone family of antibiotics in the early 1970s. A particularly important member of this group, ciprofloxacine , was approved for human use in the US in late 1980s. There continues to be extensive work being done in the development of new fluoroquinolones.
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Alfa - Difluoromethyl Heterocyclic Fluorinated Building Blocks
Introducing fluorine atom(s) into bioactive organic compounds has become a leading strategy for drug design and lead optimization. In drug synthesis strategy, fluorine is frequently employed to modify biologically relevant properties such as metabolic stability, basicity, lipophilicity and bioavailability. Additionally, the binding affinity of compounds to biological targets may also improve upon fluorination, therefore fluorine is considered an excellent ...
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Alfa - Fluorinated Azaindoles
Azaindoles and their derivatives exhibit significant biological activities, hence they are widely concerned in terms of drug optimization strategies. The four azaindole positional isomers, which associate a pyridine and a pyrrole ring by a fused C-C bond, possess all of the criteria necessary to be excellent bioisosteres of the indole or purine systems. The physicochemical and pharmacological properties such as solubility, pKa and lipophilicity, target ...
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Fluorinated Building Blocks - Organic Fluorinated Compounds
The carbon–fluorine chemical bond is the strongest bond in organic chemistry, which is one of the most important factors contributing to the great stability of the organic fluorinated compounds. Fluorine is unique in that it is possible to replace hydrogen by fluorine in organic compounds without gross distortion of the geometry of system. The applications of fluorine-containing organic compounds span virtually the whole range of the chemical and life science and it is quite clear that wherever organic chemistry, biochemistry and chemical industry progress, organic fluorinated compounds will play an important role.
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Alfa - Alkenyl Fluorinated Building Blocks
Fluorinated molecules occupy a significant place in pharmaceutical, agrochemical, and material sciences, due to the unique properties of the fluorine atom. The introduction of a fluorine atom can modulate the properties of a bioactive molecule, which may lead to changes in solubility, lipophilicity, metabolic stability, conformation, hydrogen-bonding ability and chemical reactivity. Within the various fluorinated compounds, fluorinated alkenyl is of ...
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Alfa - Alkyl Fluorinated Building Block
Alkyl fluorinated building blocks are a series of alkyl compounds substituted by fluorine atoms, which occur in a wide range of products. According to the number of fluorine substituents, they can be divided into monofluoro, polyfluoro and perfluorinated alkyl compounds. Current interest in fluorination chemistry is largely a consequence of the properties that fluorine substitution can impart on molecules, such as pharmaceuticals, agrochemicals, ...
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Alfa - Aryl Fluorinated Building Block
Aryl fluorinated building blocks refer to a series of aromatic compounds possessing one or several fluorine atoms directly attached to the aromatic ring skeleton. Fluorine can provide many beneficial properties when incorporated into an Aryl. Firstly, fluorinated arenes are more lipophilic than their non-fluorinated counterparts, which can be used to advantage in drug development. Furthermore, fluorine is sometimes used as an isostere for hydrogen in ...