80 services found
Alfa Chemistry Services
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Alfa Chemistry - Medicinal Chemistry
As one of the best medicinal chemistry team in the world, Alfa Chemistry offer comprehensive medicinal chemistry support to biotech and pharmaceutical companies engaged in drug discovery and research. We can provide service for all stages of medicinal chemistry activities including hit generation and target validation, hit-to-lead optimization, lead optimization and preclinical development. We can help our customers speed up their research and tailor our ...
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Alfa Chemistry - Soil Quality Assessment
As a global leading soil quality assessment company, Alfa Chemistry provides incredible services and credible results. Alfa Chemistry is your one-stop-shop laboratory to assess soil quality. Alfa Chemistry assesses soil quality through the following indicators: Soil Physical Indicators Soil Chemical Indicators Soil Biological Indicators Our advantages: Short Detection Cycle Competitive Price Years of Experience Professional Equipment Reliable ...
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Alfa Chemistry - Donepezil for Drug Development
Donepezil is a white or almost white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane. Donepezil is a potent, selective, noncompetitive, and rapidly reversible inhibitor of acetylcholinesterase (AChEI) licensed for the treatment of Alzheimer disease (AD) and other types of dementia. Alfa Chemistry ...
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Alfa Chemistry - Parecoxib Sodium for Drug Development
Parecoxib sodium is a white or almost white crystalline powder with the chemical name sodium N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanecarboximidate which is freely soluble in water, methanol, N,N-dimethylformamide. Parecoxib sodium is an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Alfa Chemistry offers ...
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Alfa Chemistry - Tamoxifen Citrate for Drug Development
Tamoxifen citrate is an estrogen receptor antagonist and partial agonist which has been shown to induce apoptosis in human malignant glioma cells and to block VEGF production in breast cancer cells. Alfa Chemistry offers high quality tamoxifen citrate to customers which meets the CP & USP standards. Please feel free to contact us for APIs or technical services. Learn more at ...
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Alfa Chemistry - Dexmedetomidine Hydrochloride for Drug Development
Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1. Dexmedetomidine hydrochloride is a potent α2-adrenoceptor agonist, which produces and analgesia, about 8 times higher selective affinity for the α2/α1-adrenoceptor than clonidine. Alfa Chemistry offers high quality of dexmedetomidine hydrochloride which meets the CP & EP standards. Please feel free to contact us for APIs or technical ...
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Alfa Chemistry - Rivaroxaban - API for Drug Development
Rivaroxaban is a prescription medicine for treatment of thromboembolic diseases mainly used to treat and prevent the symptoms of the deep vein thrombosis (DVT) prior to hip or knee replacement surgery, treat the venous thromboembolism (VTE) and nonvalvular atrial fibrillation, and treat DVT and pulmonary embolism (PE). Alfa Chemistry offers high quality of rivaroxaban which meets the CP. Please feel free to contact us for APIs or technical services. Learn ...
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Alfa Chemistry - Epalrestat - API for Drug Development
Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. Alfa Chemistry offers high quality epalrestat to customers which meets the CP & JP standards. Please feel free to contact us for APIs or technical services. Learn more at ...
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Alfa Chemistry - Lenalidomide - API for Drug Development
Lenalidomide can be used in the treatment of various of cancers and anemia in patients with certain blood/bone marrow disorders. Alfa Chemistry offers high quality of lenalidomide which meets the CP, EP & USP. Please feel free to contact us for APIs or technical services. Learn more at ...
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Alfa Chemistry - Tofacitinib Citrate - API for Drug Development
Tofacitinib citrate, chemically named as (3R,4R)-3-[4-methyl-3-[N-methyl-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropionitrile citrate, is a white or almost white powder, which is lightly soluble in water, very slightly soluble in methanol, and practically insoluble in acetone. Tofacitinib citrate is a novel, oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Alfa ...
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Alfa Chemistry - Edaravone - API for Drug Development
Edaravone, a member of the substituted 2-pyrazolin-5-one class, has the chemical name 3-methyl-1-phenyl-2-pyrazolin-5-one. It is a white crystalline powder and is freely soluble in acetic acid, methanol, or ethanol, as well as slightly soluble in water or diethyl ether. Edaravone is available as a clear, colorless liquid provided as a sterile injection solution supplied for intravenous (IV) infusion. Alfa Chemistry offers high quality of edaravone which ...
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T,C&A Lab - Pharmaceutical Testing
The purpose of pharmaceutical testing is to prevent substandard pharmaceuticals from entering the market and ensure the safety of pharmaceuticals. T,C&A Lab provides analysis and testing services for a wide range of products from raw materials to finished products in the pharmaceutical and biopharmaceutical industries. Raw materials, intermediate products and by-products Finished products Additives ...
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T,C&A Lab - Pharmaceutical Microbiology Testing
The detection of microbial limit is one of the important measures to ensure its quality and drug safety. T,C&A Lab runs strictly in accordance with GMP and GLP standards to meet the relevant requirements of compliance, quality, efficiency, etc. We can perform microbiology testing according to USP , and . Welcome to contact our experts for consultation. Learn more atbout ...
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T,C&A Lab - Stability Testing of Pharmaceutical Products
The stability of pharmaceutical products refers to the ability of APIs and preparations to maintain their physical, chemical, biological and microbiological properties. The purpose of stability study is to investigate the changes of the properties of APIs or preparations with time under the influence of temperature, humidity, light and other conditions, so as to provide a scientific basis for the determination of drug production, packaging, storage, ...
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T,C&A Lab - Extractables & Leachables Testing
Extractable compounds are compounds that can be extracted from plastics or elastic materials by solvents with different physical and chemical properties under certain conditions. Leachables are compounds that migrate from plastic or elastic materials into drugs under normal conditions of use. GPM guidelines around the world require that the surface in contact with the drug should not be reactive, additive or absorbent, so that the safety, strength, purity ...
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Alfa Chemistry - PF-06821497
PF-06821497 is a potent EZH2 Inhibitor which can be used for the treatment of relapsed/refractory SCLC (small cell lung cancer), castration resistant prostate cancer, and follicular lymphoma. Alfa Chemistry offers high quality of PF-06821497 which can be a potent EZH2 Inhibitor for the treatment of relapsed/refractory SCLC (small cell lung cancer), castration resistant prostate cancer, and follicular lymphoma, etc. Please feel free to contact us for APIs ...
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Alfa Chemistry - MRTX0902
MRTX0902 is a potent SOS1 inhibitor which can be used for the therapeutic intervention of KRAS-driven (Kirsten rat sarcoma virus driven) cancers. Alfa Chemistry offers high quality of MRTX0902 which can be used as a potent SOS1 inhibitor for the therapeutic intervention of KRAS-driven cancers. Please feel free to contact us for APIs or technical services. Learn more at ...
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Alfa Chemistry - Molecular Property Prediction
Alfa Chemistry provides access to molecular property prediction services for worldwide customers. Our platform with state-of-the-art methods and highly expert computational chemists is available to promote the development of chemical and pharmaceutical fields. We guarantee the best services for you. Learn more: ...
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Alfa Chemistry - Application of Computational Techniques in Each Phase of Drug Design
Nowadays, computational methods are routinely used to accelerate drug discovery process. In drug design and discovery, multiple computational chemistry approaches are employed to calculate and predict events, such as the drug binding to its target and the chemical properties for designing potential new drugs. At Alfa Chemistry, we apply the knowledge of computational chemistry to create various physics-based algorithms, and use computers to simulate ...
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Alfa Chemistry - GMP Manufacturing
Contract Manufacturing Organization Alfa Chemistry is the one of the leading companies for ADC drug development in the world that provides technically challenging service from development to commercial production including both payload and ADC. Alfa CDMO is equipped with state-of-the-art fill/finish equipment with aseptic filling and lyophilization with automated operation to ensure manufacturing with efficient control. Innovative linker/payload ...
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Alfa Chemistry - Biopharmaceutical Contract Research
Alfa CDMO's CRO offers custom services for research, optimization, and development phases of your project. ANTIBODY ENGINEERING CHEMICAL SYNTHESIS ANTIBODY DRUG CONJUGATION SCREENING ADC Assay and Mechanism Study Learn more: ...
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Alfa Chemistry - An industry leader in biopharmaceutical contract manufacturing
Alfa CDMO provides global CDMO services in the development and manufacturing of biopharmaceuticals, including mAbs, recombinant proteins, ADCs and bispecifics. We offer our partners contract services from DNA to finished drug product. Our technical expertise allows us to provide effective high-quality solutions for our partners biomanufacturing needs. In addition, Alfa CDMO delivers our commitment to our partners through our quality manufacturing, meeting ...
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Alfa Chemistry - Surface Analysis for Alternative Energy
In developing functional materials, most people are concerned with their characteristics like chemical reactivity, durability, adhesion, electrical properties, optical properties, corrosion-resistance and compatibility, etc. Particularly, the surface properties of materials are directly related with these concerns. Learn more at ...
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Alfa Chemistry - ADMET Prediction
Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. Alfa Chemistry can predict ADME parameters and pharmacokinetic properties by calculating the physical and chemical indicators of one or more small ...
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Alfa Chemistry - Atomistic and Coarse-grained Modeling of Pharmaceutical Formulations
Computational pharmaceutics is able to provide rational, deductive, and knowledge-based strategies in pharmaceutics with the use of high performance computing systems. Scientists therefore apply this unique technology to build atomistic and coarse-grained models of pharmaceutical formulations, revealing more and more important mechanistic details. Alfa Chemistry provides a profound insight into the full-length molecules and its higher-level hierarchical ...
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Alfa Chemistry - Chemical Space Docking for drug design
Chemical space docking is a novel approach for virtual screening which allows for handling multiple molecules occurring in combinatorial chemical spaces. Chemical space docking aims to predict actives based on their binding mode after a docking procedure with subsequent scoring of the complexes. Yet the source of the docked molecules is no longer an enumerated library but a combinatorial built-up 'space' of zillions of molecules. Learn more at
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Alfa Chemistry - Drug Design - Combinatorial Library
All combinatorial library methods include the following three main steps: library preparation, library components screening, and chemical structures of active compounds determination. The goal of chemical compound library design is to reduce the number of molecules as well as maintain the diversity of the library. Combinatorial library therefore has the potential of finding leads more rapidly since only a smaller number of molecules are required to be ...
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Alfa Chemistry - Dominant Skeleton Discovery and Screening
In chemical concepts, dominant skeleton refers to the core structure of small molecules. In computational chemistry and medicinal chemistry, the skeleton also has the same meaning. The discovery of active compounds with novel skelecton is a great challenge for modern medicinal chemistry. It can not only improve the efficacy and drug-like properties of molecules, but also help pharmaceutical companies break patent barriers and build core competitiveness. ...
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Alfa Chemistry - Lead Optimization
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds or biologics in lead optimization process. Learn more at
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Alfa Chemistry - Property Prediction of Drug-like Molecules
The Alfa Chemistry platform integrates predictive methods with various computational techniques to accelerate drug discovery. Our iterative process is designed to accelerate evaluation and optimization of chemical matter in silico ahead of synthesis and assay. The most promising compounds emerging from each round of experimental project chemistry are then further optimized through additional cycles of computation analysis. Learn more at
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Alfa Chemistry - High Throughput Quantum Chemistry
High throughput quantum chemistry has been proven an invaluable tool in informing experimental discovery and development efforts. Challenge of chemical process calculation is tackled by allowing computations via a direct application programming interface and by encouraging machine-readable input and ...
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Alfa Chemistry - Identification of Rate-limiting Reaction Steps for drug discovery
Identification of Rate-limiting Reaction Steps: By analyzing the structure of the reaction intermediates and transition states, the rate-limiting steps of the reaction can be determined combined with kinetic methods. Several remarkable computational methods have been developed to search for the transition states and analyze the mechanism of the entire reaction. Scientists can ...
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Alfa Chemistry - Catalysis and Reaction Mechanism Calculation for drug discovery
Catalysis and Reaction Mechanism Calculation: The reaction energy and reaction rate constant is analyzed through the atomic charge analysis of several important atoms participating in the reaction. In terms of complete reaction mechanism calculation, bond breaking, bond formation, transition state, and sometimes catalysis are necessarily taken into ...
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Alfa Chemistry - Calculation of Thermodynamic Data for Individual Chemical Reactions for drug discovery
Calculation of Thermodynamic Data for Individual Chemical Reactions: Thermodynamic data for chemical reactions deals with the energy change in accordance with the laws of thermodynamics. This represents macroscopic properties of the system, that is the initial and final states not involving the mechanism. It is of great benefit to understand thermodynamic ...
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Alfa Chemistry - Vibration Circular Dichroism (VCD) Spectrum Prediction for Drug Discovery
Vibration Circular Dichroism (VCD) Spectrum Prediction: As a new method for measuring the circular dichroism of molecules in the infrared wavelength region, VCD has greatly expanded the application range of circular dichroism. Scientists use it to accurately predict chirality through conformational search and quantum chemical calculations, and the chromatogram of the ...
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Alfa Chemistry - ORD Simulation Prediction for Drug Discovery
ORD Simulation Prediction: Optical rotation refers to when a beam of polarized light passes through a substance,the plane of polarized light rotates at a certain angle relative to its own direction of motion. The property of rotating polarized light that a substance has is called optical rotation. Materials with optical rotation include crystals, spin-polarized molecules and chiral molecules. For the ...
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Alfa Chemistry - Lead Optimization for Drug Discovery
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds or biologics ...
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Alfa Chemistry - Nucleic Acid Delivery Excipients for Vaccine Research
Nucleic Acid Delivery Excipients: The pharmacological effects of using naked mRNA as a vaccine are greatly reduced. To function in vivo, mRNA requires a safe, effective and stable delivery strategy that protects the nucleic acid from degradation and allows for cellular uptake and mRNA ...
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Alfa Chemistry - SARS-CoV-2 Detection Raw Materials
SARS-CoV-2 Detection Raw Materials: Nucleic acid detection, antigen detection and antibody detection are key tools for the diagnosis of COVID-19. Alfa Chemistry has the expertise and experience to provide you with the various raw materials needed in the diagnostic process. According to different detection methods, our products are classified as ...
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Alfa Chemistry - Vaccine Excipients
The manufacture and composition of vaccines are complex and are strictly regulated to maximize potency and safety. In addition to antigens, vaccines also contain some important substances—vaccine excipients. Vaccine excipients comprise all chemical compounds used in the production of vaccines, such as vaccine stabilizers, vaccine emulsifiers, preservatives and vaccine ...
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Alfa Chemistry - Vaccine Stabilizers
Vaccine Stabilizers: Successful vaccine stabilization strategies include both empirical efforts to screen and identify appropriate stabilizers and environmental conditions and more rational approaches toward developing an understanding of the causes and mechanisms of vaccine inactivation. Among these, determining the appropriate stabilizer is a critical means of maintaining vaccine potency and efficiency. Such ...
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Alfa Chemistry - Vaccine Emulsifiers
Vaccine Emulsifiers: Emulsifiers, also known as surfactants, can reduce the surface tension of the liquid, thereby increasing the diffusion and wetting properties. An emulsifier consists of a polar (or hydrophilic) head and a hydrophobic tail which can be dissolved in both polar and non-polar solvents. These emulsifiers have physicochemical properties of self-aggregation, solubilization or emulsification. Typically, ...
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Alfa Chemistry - Acetazolamide as Active Pharmaceutical Ingredient
Acetazolamide is a white to yellowish-white fine crystalline powder that is slightly soluble in acetone, insoluble in chloroform, diethyl ether and carbon tetrachloride. The chemical name of it is 2-acetamido-1,3,4-thiadiazole-5-sulfonamide. Acetazolamide is a first-generation carbonic anhydrase (CA) inhibitor, which is most commonly used in the treatment of ...
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Alfa Chemistry - Benzhexol Hydrochloride as Active Pharmaceutical Ingredient
Benzhexol hydrochloride is a class of antimuscarinic drug with the chemical name (±)-a-cyclohexyl-1-phenyl-3-(1-piperidinyl)-propanol hydrochloride. It was approved by the FDA for the treatment of Parkinson's disease (PD) in the United States in 2003. By improving muscle stiffness, benzhexol hydrochloride allows the body to move normally. Alfa Chemistry offers high quality benzhexol hydrochloride. Please feel free ...
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Alfa Chemistry - Chlorquinaldol as Active Pharmaceutical Ingredient
Chlorquinaldol is monohydroxyquinoline, or quinolin-8-ol that is substituted by a methyl group at position 2 and chlorine at positions 5 and 7. It is a solid insoluble in water and the chemical name of chlorquinaldol is 5,7-dichloro-2-methyl-8-hydroxyquinoline. Chlorquinaldol is an antimicrobial agent used in the treatment of bacterial vaginosis. Alfa Chemistry offers high quality chlorquinaldol. Please feel free to contact ...
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Alfa Chemistry - Vaccine Adjuvants
Vaccine adjuvants are ingredients in vaccines added to improve the immune response after immunization. Modern vaccines usually contain only a portion of bacteria or viruses as their antigens and therefore require the help of adjuvants to induce a protective immune response. Vaccine adjuvants are of a diverse family, and hence, cannot be defined using a single integrated ...
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Alfa Chemistry - Preservatives as Vaccine Excipients
Preservatives are needed to prevent contamination of multi-dose vials each time individual doses are drawn. Alfa Chemistry supplies preservatives to companies researching vaccines. If you cannot find the preservative you need, please contact us. We also offer product customization according to customer's detailed ...
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Alfa Chemistry - Ancitabine Hydrochloride as Active Pharmaceutical Ingredient
Ancitabine Hydrochloride: Ancitabine hydrochloride is a white needle-like crystal or crystalline powder that is freely soluble in water, slightly soluble in methanol and ethanol, and almost insoluble in ether, benzene and chloroform. The chemical name of it is 2-methanolyl 2,3,3a,9a-tetrahydro-3hydroxy-6-imino-6H furan-(2',3',4,5)-oxazole(3,2a) pyrimidine hydrochloride. Ancitabine hydrochloride is the hydrochloride ...
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Alfa Chemistry - Cyclophosphamide as Active Pharmaceutical Ingredient
Cyclophosphamide: Cyclophosphamide, also known as cytophosphane, appears as a white to almost white crystalline powder with a slightly bitter taste. The chemical name of it is p-[N,N-bis-(2-chloroethyl)]-1-oxo-3-nitrogen-2-phosphocyclohexane-p-oxide monohydrate. Cyclophosphamide is a synthetic alkylating agent chemically related to nitrogen mustard with antineoplastic and immunosuppressive activities, which was approved for ...
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Alfa Chemistry - Cytarabine Hydrochloride as Active Pharmaceutical Ingredient
Cytarabine Hydrochloride: Cytarabine hydrochloride is a white to off-white crystalline with the chemical name 1-β-D-arabinofuranosyl-4-amino-2(1H)-pyrimidinone hydrochloride. Cytarabine hydrochloride is used in chemotherapy for white blood cell cancers, especially acute myeloid leukemia ...
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Alfa Chemistry - Phospholipids for vaccine development
Phospholipids as Nucleic Acid Delivery Excipients: Phospholipids are unique and versatile molecules that are a key component of all cell membranes. A phospholipid consists of two basic parts: the hydrophilic head and the hydrophobic tail. The hydrophilic head consists of a glycerol molecule bound to a phosphate group. These groups are polar and are attracted to ...
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Alfa Chemistry - Pharmaceutical Glass for Pharmaceutical Packaging
Pharmaceutical Glass: A large number of drugs are packaged in glass containers. Glass containers can be broadly classified into four types. They include, Type I glass containers (borosilicate glass/neutral glass), Type II glass containers (soda-lime-silica glass/ treated soda-lime glass/ de alkalized soda lime glass), Type III glass containers (regular soda lime glass) and Type IV glass containers (type NP ...
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Alfa Chemistry - Antibody Detection Raw Materials for ARS-CoV-2 Detection
Antibody Detection Raw Materials: SARS-CoV-2 infection can stimulate the body to produce specific antibodies. This means that researchers can determine whether a person has been infected with SARS-CoV-2 by detecting the presence of immunoglobulin G (IgG) or immunoglobulin M (IgM). IgG is the most abundant neutralizing antibody that persists in the blood from two weeks to four months after onset, while ...
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Alfa Chemistry - Moxifloxacin Hydrochloride as API
Moxifloxacin hydrochloride, with broad-spectrum bactericidal activity against gram strains, is commonly used in the treatment of respiratory tract infection, including acute sinusitis, acute attack of chronic bronchitis, community acquired pneumonia, etc. Alfa Chemistry offers high quality of moxifloxacin hydrochloride. Please feel free to contact us for APIs or technical ...
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Alfa Chemistry - Nimustine Hydrochloride as API
Nimustine hydrochloride can alkylate and cross-link DNA, which induces DNA replication blockade and DNA double-strand breaks, leading to the failure of DNA synthesis. In this way, nimustine hydrochloride exerts an anti-tumor effect, especially on malignant brain tumors. Alfa Chemistry offers high quality nimustine hydrochloride. Please feel free to contact us for APIs or technical ...
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Alfa Chemistry - Glycine as API
Glycine is a white crystalline powder that is very soluble in water, slightly soluble in acetone, and insoluble in ethanol and ethyl ether. It is the simplest (and the only achiral) proteinogenic amino acid with the chemical name aminoacetic acid. Currently, glycine is used in medicine as a raw material for the synthesis of chlortetracycline buffer, anti-Parxinsen disease drug L-dopa, vitamin B6, threonine and so on. It is also ...
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Alfa Chemistry - Nitrocellulose Membranes as Excipients
Nitrocellulose (NC) membranes are a series of paper-like matrices with micro-scale porous structures. Due to their good biocompatibility, unique physical and chemical properties, and the ability to immobilize various biomolecules, NC membranes have been widely used in the biomedical field. For example, NC membranes are commonly used to immobilize nucleic acids in southern blots and northern blots, and to ...
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Alfa Chemistry - Dyed Microspheres
One of the mainstream antibody-labeled tracers for this technique is dyed microspheres. The dyed microspheres are based on white polystyrene microspheres and are prepared by a unique internal dyeing process. The internal dyeing process makes the dye inside the microsphere, so it is not easy to leak and has a relatively stable morphological structure. The series of products are rich in color and have a variety of ...
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Alfa Chemistry - SARS-CoV-2 Nucleocapsid Protein, His Tag
SARS-CoV-2 Nucleocapsid Protein, His Tag: This product is specifically designed for serological test development. This product can be stored stably for 3 months under sterile conditions from −20 to −80 ...
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Alfa Chemistry - OLED and PLED Materials
OLED and PLED Materials: OLED is an emerging display and lighting technology that can realize beautiful and efficient display and lighting panels. Thin OLEDs have been used in many mobile devices and TVs. There are two main types of OLEDs: OLEDs based on small molecules and polymer OLEDs. Two materials can be used to make OLEDs: small molecules (SM-OLED) or large molecules or ...
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Alfa Chemistry - MRTX0902 as Active Pharmaceutical Ingredient
MRTX0902 is a potent SOS1 inhibitor which can be used for the therapeutic intervention of KRAS-driven (Kirsten rat sarcoma virus driven) cancers. Rat sarcoma (RAS) is the most frequently mutated oncogene in human cancer, with KRAS being the most commonly mutated RAS isoform. Overall, KRAS accounts for 85% of RAS mutations observed in human cancers and is present in 35% of lung adenocarcinomas ...
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Alfa Chemistry - Oseltamivir Phosphate as API
Oseltamivir phosphate is hydrolyzed in the liver to its active form and which is a potent and selective inhibitor of influenza virus neuraminidase. This enzyme is important for the entry of the virus into uninfected cells, the release of newly formed virus from infected cells, and the further spread of the infectious virus in the body. Thus, oseltamivir phosphate treats influenza by reducing viral infectivity. Clinical ...
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Alfa Chemistry - Drug Research Service Platforms
Drug Research Service Platforms: Due to Alfa Chemistry's deeply ingrained research and development capabilities, we have been able to advance technologically in both research and development. In addition, we have been able to provide an integrated service platform for our customers' novel medication development ...
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Alfa Chemistry - Drug Discovery and Research
Drug Discovery and Research: Alfa Chemistry aims to support efforts to generate novel drugs by serving as a one-stop platform for the variety of services and expertise needed for drug discovery and development. We will collaborate through a combination of integrated, multidisciplinary drug discovery expertise and capabilities across modality targets, platforms and therapeutic areas. We use a variety of ...
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Alfa Chemistry - Clinical Pathology Laboratory
Clinical Pathology Laboratory: Pathology is a bridge discipline between basic and clinical medicine. The pathological examination can help diagnose diseases, understand the occurrence, development, and regression of diseases, especially identify the origin, nature, and scope of tumor tissues, determine the prognosis of tumors, and guide clinical treatment, especially targeted therapy. A team of pathology ...
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Alfa Chemistry - Fluorouracil
Fluorouracil is a white to nearly white crystalline powder that is sparingly soluble in water and alcohol. The chemical name of it is 5-fluoro-2,4(1H,3H)-pyrimidinedione. Fluorouracil is a cytotoxic chemoradiotherapy medication used to treat rectal cancer, head and neck cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer by intravenous ...
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Alfa Chemistry - Ifosfamide
Ifosfamide has been effectively employed in the treatment of multiple cancers, including testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, non-Hodgkin lymphoma, Hodgkin lymphoma, epithelial ovarian cancer, cervical carcinoma and germ cell carcinoma of the ovary[1]. Among all these cancers, the Food and Drug Administration (FDA) has approved ifosfamide only for testicular cancer. A study ...
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Alfa Chemistry - Epoxy Resins
Epoxy resin refers to a general term for a class of polymers containing more than two epoxy groups in the molecule. It is a polycondensation product of epichlorohydrin and bisphenol A or polyol. Due to the chemical activity of epoxy groups, a variety of compounds containing active hydrogen can be used to open the ring, curing crosslinking to generate a network structure, so epoxy resin is a thermosetting resin. ...
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Alfa Chemistry - Product Testing Services
Alfa Chemistry specializes in a wide range of testing and inspection services, as an internationally accredited inspection organization. Our diversified testing services are widely used in consumer products, including cosmetics, food and health products, pharmaceuticals, pharmaceutical packaging materials, disinfection products, clean rooms, herbal residues, pesticides, chemicals, ...
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Alfa Chemistry - Hydrocortisone Butyrate
Hydrocortisone butyrate is a synthetic glucocorticoid. Binding and activation of the glucocorticoid result in the activation of lipocortin that inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, a precursor for inflammatory mediators prostaglandins and leukotrienes, thereby inhibiting inflammation. In addition, glucocorticoid also stimulates lipocortin-1 release ...
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Alfa Chemistry - Excitation Energy and Transition Dipole Moment (TDM) Calculation
Excitation Energy and Transition Dipole Moment (TDM) Calculation: For atoms, the arrangement of valence electrons on the periodic table of elements is the ground state, and electrons are excited from the lower energy orbit to the higher energy orbit, which is the excited state. The energy absorbed in this process is called excitation energy. There are two forms of ...
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Alfa Chemistry - Lot Release Testing
Lot release testing includes physical and chemical testing to ensure that the product meets the defined specifications. It is not only a key component of the quality control process for biologics, but also the basis for drug development. Before a biological product can be released for use, sale or export, lot release testing must be performed. We have the ability to provide you with lot release testing to help your ...
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Alfa Chemistry - Preclinical Drug Research
One of the most important steps in the process of developing a medicine is determining its safety. Alfa Chemistry is dedicated to providing pre-clinical drug research services to support our clients' drug development, pre-clinical and clinical investigations, and assist them in deciding which drug candidates are most worthwhile to pursue in clinical trials. We emphasize pharmacology, pharmacokinetics, medication ...
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Alfa Chemistry - Drug Safety Evaluation
Alfa Chemistry has established a drug safety evaluation system that meets international standards. Our experimental studies strictly follow ICH, CFDA, FDA and OECD guidelines, providing our clients with high quality data and fast study cycles for preclinical safety evaluation of drugs. alfa chemistry helps our clients to shorten the experimental time and reduce the cost of new drug development through cost ...
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Alfa Chemistry - Active Pharmaceutical Ingredients - Methotrexate
Methotrexate, one of the earliest cancer chemotherapy agents, which is extensively used in the treatment of cancer, including breast cancer, leukemia, lung cancer, lymphoma, osteosarcoma and so on. The efficacy of methotrexate mainly due to its inhibitory effect on dihydrofolate reductase (DHFR)[1]. DHFR catalyzes the conversion of dihydrofolate to the active tetrahydrofolate that is needed for the synthesis ...
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Alfa Chemistry - Active Pharmaceutical Ingredients - Sulfamethoxazole
Sulfamethoxazole, a sulfanilamide, is a structural analog of para-aminobenzoic acid (PABA). It competes with PABA to bind to dihydropteroate synthetase and inhibits the conversion of PABA to dihydrofolic acid. Inhibition of this pathway ultimately prevents the synthesis of folate that is a critical role during DNA synthesis. Therefor, sulfamethoxazole can inhibit the growth and replication of bacteria by ...
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Alfa Chemistry - Clinical Testing Laboratory
Clinical Testing Laboratory: In order to provide an accurate and scientific basis for animal investigations, Alfa Chemistry's clinical testing laboratory performs clinical testing services such as animal biochemistry, hematology, coagulation, urinalysis, urine sediment microscopy, lymphocyte typing, in vitro hemolysis, and metabolite analysis. Our laboratory has highly automated tests and manual tests. Our ...
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Alfa Chemistry - Flavors and Fragrances Analysis
Modern flavors and fragrances are complex formulated products containing blends of aroma compounds with auxiliary materials, enabling desirable flavors or fragrances to be added to a large number of products. If in the past they were analyzed only for the identification of constituents, today their analysis has become necessary to comply with international regulations. Alfa Chemistry is committed to providing ...
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Alfa Chemistry - Pest Control-Cyclopropyl methyl ketone as Ketone-functionalized Pheromone
CAS 765-43-5 IUPAC Name 1-cyclopropylethanone Synonyms Ethanone, 1-cyclopropyl-;cyclopropyl m-nitrophenyl ketone;cyclopropyl meta-nitrophenyl ketone;acetylcyclopropane;Cyclopropyl methylketone Molecular Weight 84.12g/mol Molecular Formula C5H8O Canonical SMILES CC(=O)C1CC1 InChI InChI=1S/C5H8O/c1-4(6)5-2-3-5/h5H,2-3H2,1H3 InChI ...
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Alfa Chemistry - Biobased Pharmaceutical Chemicals
Generally, according to the source from which they are generated, pharmaceutical chemicals are considered as biobased (or natural), synthetic, or semi-synthetic. The natural environment remains a significant origin of novel therapeutic agent compounds. Biobased pharmaceutical chemicals are prepared from compounds found occurring in nature, containing active components in extract form obtained from sources, ...