2 products found
Arch Oncology, Inc. Products
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Arch - Model AO-176 - Antibody for Cancer
We are advancing our pipeline of antibodies for the treatment of patients with cancer. AO-176 is a highly differentiated anti-CD47 IgG2 antibody currently in clinical trials for solid tumors and multiple myeloma. AO-176 works by blocking the “don’t eat me” signal enabled by CD47’s interaction with SIRPa and inducing phagocytosis. It has a unique combination of features, including lower binding to normal cells in general and ...
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Arch - Model Anti-CD47 - Antibody for Cancer
Anti-CD47 therapies block the CD47/SIRPα interaction, the “don’t eat me” mechanism for macrophages. AO-176 is a humanized anti-CD47 IgG2 monoclonal antibody with a potential best-in-class profile. Beyond blocking, AO-176 has several additional mechanisms of action that make this a highly-differentiated therapy among agents in this ...