Bio-Tissue, Inc. products

PROKERA biologic corneal bandage devices are used by eye doctors around the world to heal and treat ocular conditions such as keratitis, moderate to severe dry eye disease, recurrent corneal erosions, filamentary keratitis, persistent epithelial defects, neurotrophic corneas, herpetic ulcers, and many other ocular surface diseases such as chemical burns and Stevens-Johnson syndrome. The PROKERA family of products – PROKERA Slim, PROKERA, PROKERA Clear and PROKERA Plus reduce inflammation, prevents scarring and simultaneously promote regenerative healing of the ocular surface.

Regenerative healing restores the body to the same level of function as it had prior to injury or disease. By the 1970’s, science was beginning to document observations that fetuses in early gestation experienced a healing process vastly different than what is experienced outside of the womb.^2,3 With the advent of in utero surgery in the 1980’s, direct observation of clinical outcomes of fetal healing demonstrated that it was regenerative in nature.  Research has shown that this occurs because the placental tissues, particularly the umbilical cord and amniotic membrane, have innate healing properties. More importantly, these properties can be preserved and transplanted to other environments to promote healing.

TissueTech’s initial research and development efforts were focused on the development of its cornerstone cryopreservation technology – CRYOTEK. The CRYOTEK process is a proprietary tissue-processing method that preserves the innate biological and structural integrity of the natural placental tissue and therefore preserves and delivers the anti-inflammatory, anti-scarring, and anti-angiogenesis properties of that matrix. In particular, the CRYOTEK process is the ONLY method proven to effectively retain the Heavy Chain Hyaluronic Acid/Pentraxin3 (HC-HA/PTX3) complex, which has been demonstrated to orchestrate an environment that promotes regenerative healing. CRYOTEK-processed tissues are also the only available placental allografts that have been shown to be equivalent to fresh placental tissue and superior to other available placental allografts that are provided in a dehydrated state.

AmnioGraft is a biologic ocular transplantation graft used by eye surgeons around the world as an adjunct therapy to treat ocular surface indications such as corneal ulcers, pterygium, mechanical dry eye (also known as conjunctivochalasis), excision of tumors, chemical burns, and Stevens-Johnson Syndrome. AmnioGraft serves as a tissue replacement by delivering the unique therapeutic actions of cryopreserved amniotic membrane.

Consistent with our mission of continued innovation, TissueTech more recently commercialized allografts preserved via our proprietary SteriTek preservation process.  This unique technology yields a shelf-stable product while maintaining the natural hydration of the tissue. The tissue is cleaned, processed and packaged consistent with the CRYOTEK cryopreservation process to maintain the structural and biological integrity of the natural tissue, but is then terminally sterilized using gamma irradiation, yielding a fully hydrated product that can be stored at controlled room temperature.

AmnioGuard is an umbilical cord graft used by Oculoplastic surgeons for several indications. Due to its high tensile strength and thickness, AmnioGuard is easy to handle and suture and can be used for corneal, conjunctival, sclera, fornix, socket, and eyelid reconstruction.

4-Terpineol Formula – Extracted from tea tree oil to provide maximum benefit, without damaging the skin. Scientific studies have shown that T4O is the most important component found in tea tree oil for killing Demodex mites.

PROKERA biologic corneal bandage devices are used by eye doctors around the world to heal and treat ocular conditions such as keratitis, moderate to severe dry eye disease, recurrent corneal erosions, filamentary keratitis, persistent epithelial defects, neurotrophic corneas, herpetic ulcers, and many other ocular surface diseases such as chemical burns and Stevens-Johnson syndrome. The PROKERA family of products – PROKERA Slim, PROKERA, PROKERA Clear and PROKERA Plus reduce inflammation, prevents scarring and simultaneously promote regenerative healing of the ocular surface.

AmnioGraft is a biologic ocular transplantation graft used by eye surgeons around the world as an adjunct therapy to treat ocular surface indications such as corneal ulcers, pterygium, mechanical dry eye (also known as conjunctivochalasis), excision of tumors, chemical burns, and Stevens-Johnson Syndrome.

Deep Cleaning – Its main component 4-Terpineol, extracted from tea tree oil, penetrates deep within the skin to cleanse it. A natural cleanser, it wipes away dirt, debris, and residual oils.