92 Articles found
CD Genomics Articles
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Long-Read: Nanopore Full-Length Transcriptome Sequencing
Nanopore full-length transcriptome sequencing is an innovative technique that utilizes Oxford Nanopore Technologies' (ONT) sequencing platform to obtain comprehensive and uninterrupted high-quality full-length sequences of transcripts. This ...
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The Beginner's Guide to Exosome RNA-Seq
Exosomes are small extracellular vesicles that contain RNA, proteins, and lipids. These vesicles play a crucial role in intercellular communication and have been implicated in various physiological and pathological processes. Exosome ...
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The Role of Exosome RNA in Cancer
The Relationship Between Exosomes and Cancer Exosomes are nanoscale vesicles derived from intracellular lysosomes that shuttle a variety of biomolecules, such as nucleic acids, proteins, lipids, amino acids and metabolites, and play a key role in ...
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Overview of Microbial Epigenetics
Introduction to Microbial Epigenetics Epigenetics has been defined as the study of stable alterations in gene expression potentials that arise during development and cell proliferation, or alterations in DNA function without alterations in DNA ...
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Nanopore Sequencing: Bioinformatics Analysis of ONT Data
Oxford Nanopore Technologies (ONT) sequencing has witnessed significant progress in recent years, becoming a key player in the genomics field. As the technology matures, so does the bioinformatics analysis of ONT data. Researchers have ...
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CD Genomics Takes Genomic Research to New Heights with Ribo-seq Technology
CD Genomics, a well-established leader in transcriptome solutions, is pleased to announce the introduction of Ribosome Profiling technology. This innovative technique promises to provide valuable insights into gene expression, protein synthesis, and ...
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A Primer in Biological Data Analysis and Visualization
With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the ...
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Comparison Between Illumina and Nanopore Sequencing Technologies
What is Illumina Sequencing? Illumina sequencing is a second-generation sequencing technology that has become a powerful tool for genomics research. The method uses reversible dye terminator technology to detect the sequence of a DNA molecule. The ...
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Epitranscriptomic Modifications and How to Detect Them
What is epitranscriptomic modification? RNA modifications, not limited to purine or pyrimidine bases, including N6-methyladenosine (m6A), 1-methyladenosine (m1A), 5-methylcytidine (m5C), 5-hydroxymethylcytidine (hm5C), 5-formylcytidine (f5C), ...
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Chimeric RNA and Sequencing Technologies: Advancing Detection and Research
What is Chimeric RNA? Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular ...
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The Basics and Beyond of PacBio SMRT Sequencing
What is PacBio sequencing?PacBio sequencing platform is a single-molecule real-time sequencing technology developed by Pacific Biosciences. PacBIo sequencing features long read length, high accuracy, uniform genome coverage, and detection of ...
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Unveiling Gene Isoforms by RNA Sequencing: Detection Methods and Applications
What Is Gene Isoform? Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell ...
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The Molecular Microbiology of SARS-CoV-2: Detection Methods and Infection Mechanism
SARS-CoV-2 is a newly discovered human coronavirus group (HCoV), which are single-stranded RNA viruses belonging to the family of Coronaviridae. A range of respiratory diseases have been induced by some of these pathogens in the past. ...
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Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances
What is pan-genome? A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and ...
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qPCR for SARS-CoV-2 Detection and Research: Introduction, Principles, and Applications
Introduction to Quantitative Polymerase Chain Reaction A highly delicate technique for the amplification and identification of deoxyribonucleic acid is polymerase chain reaction (PCR). In molecular biology, its conceptual simplification ...
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RNA Splicing and How to Target It
What Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding ...
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What Is the Difference Between Aerobes and Anaerobes?
Microorganisms, specifically bacteria, have been classified into several groups depending on different characteristics such as physical appearance, culture properties, energy and nutrient requirement, biosynthetic capacity, optimal growth ...
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What Is Microbiome and How to Study It
The term microbiome comes from the Greek word micro which means small and bios meaning life. It is defined as "a characteristic microbial community occupying a reasonable well-defined habitat which has distinct physiochemical properties". Many ...
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Differential Gene Expression (DGE) Analysis in RNA Sequencing
What Are DEGs in Genetics? DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to ...
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Single-Cell RNA Sequencing in Drug Discovery and Development
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular ...