166 services found
Creative Biolabs Services
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Antibody Design and Conjugation
To retain antibody bioactivity, mild, near-physiological conditions are often used for conjugation reactions. Under these conditions, endogenous amino acids such as Lys and Cys are chemically reactive and can be used as conjugation ...
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ADC In Vitro Analysis
The construction of an antibody-drug conjugate (ADC) is the covalent coupling of a monoclonal antibody and a toxic payload drug via a linker molecule. The ultimate goal for an ADC development project is to deploy the resulted ADC into in vivo systems, both in model animals and eventually human patients, to cure cancer and other diseases utilizing its payload efficacy. However, prior to in vivo deployment, information regarding basic biochemical ...
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Antibody Design and Conjugation
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely controlled site-directed conjugations and subsequently a narrower ...
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ADC Pharmacokinetics Characterization
Pharmacokinetics (PK) studies provide critical information regarding the behavior of a drug in circulation and its ultimate form after extensive in vivo metabolism. Results from PK studies often serve as guidelines for clinical trials designs, especially in the development of an antibody-drug conjugate (ADC). Due to the heterogeneous nature of ADCs, multiple analytes have to be assessed to reveal the ADC PK characteristics, making these studies more ...
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ADC Linkers
Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ...
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Antibody Design and Conjugation
One downside in using the endogenous amino acids for ADC development is a heavily dispersed drug-to-antibody ratio (DAR) caused by the non-uniform distribution of the conjugation sites, especially in the case of Lysine-based ...
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Conjugate Sites Analysis
As one important aspect in ADC characterization, the identification of the conjugate sites provides an accurate map of the payload positions on a mAb. This set of results is extremely helpful in the prediction/validation of the effects on antigen binding activities induced by the conjugation process and in identification of bio-similarity ADC products. Conjugate sites analysis and determination is achieved by peptide mapping using highly sensitive and ...
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One-Stop ADC Development Service
A successful ADC should be chemically and physiologically stable in blood stream, exert similar antigen binding pattern compared with the unconjugated antibody, and exhibit desired payload toxicological effects once ...
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γδ T Cell Therapy Development Services for Tumors and Cancers
γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains. Compared to αβ T cells, γδ T cells without MHC restriction on tumor antigen recognition have strong cytotoxic effects on tumor cells. γδ T cells have been considered as wonderful effector cells for cancer immunotherapy. Creative Biolabs is an excellent expert in γδ T cell research and γδ T cell based immunotherapy. We provide a series of high-quality ...
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γδ T Cell Therapy Development for Pathogen Infections
Activation and proliferation of γδ T cells play a significant role in diverse infectious diseases induced by bacteria, viruses, and parasites and exert their potential effector function to effectively eliminate the infection. Creative Biolabs is harnessing the unique properties of γδ T cells to develop potent and targeted pathogen infection disease therapies for research use. We also offer γδ T cell-related protein and antibody products for worldwide ...
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γδ T Cell Therapy Development Services for Autoimmune Diseases
Autoimmunity is a condition in which the immune system responds to and attacks self-antigens or self healthy cells and tissues. Autoimmunity to self-antigens or a low level of autoimmunity is considered to be beneficial and important to self-defense mechanisms and immune surveillance. However, an aberrant autoimmune response that the immune system attacks and damages healthy body tissues or organs by mistake can result in a series of autoimmune diseases. ...
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γδ T Cell Development Services for Wounds Healing
Skin-resident γδ T cells as important components of skin immunity engage in wound healing, regulation of immune response to injury, inflammation, and re-epithelialization. They may present a new therapeutic approach to wound healing. As a leader in the research of γδ T cells, Creative Biolabs is driven to provide comprehensive γδ T cells development and engineering services to help regulate immune responses and favor rapid wound healing. Our scientists ...
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γδ T Cell Therapy Development Services for Neurological Diseases
γδ T cells are a distinct subgroup of T cells that play a pivotal role in many neurological diseases. They are suggested to be responsible for inducing or maintaining the proinflammatory environment characteristic of these diseases. With access to advanced instruments, fit-for-purpose laboratories, and professional knowledge, Creative Biolabs provides a full range of services to support our clients in developing γδ T cells and thus, to advance the basic ...
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γδ T Cell Therapy Development Services
As the main component of the immune system, T cells protect the body from infections and tumors by a diversity of bio-functions, including recognition and presentation specific antigens, directly killing target cells, secretion cytokines, assisting or inhibiting antibody production by B cells, etc. These functional T cells are distinguished by a variety of surface receptors, biomarkers, and biological ...
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γδ T Cell Receptors Services
Creative Biolabs is supported by an advisory board with seasoned professionals in gamma delta T cell receptors (γδ TCR) studies, γδ T cell immunologic analysis, as well as γδ T cell therapy development. We have accumulated extensive experience from the accomplishment of different projects, during which we have received a lot of recognition and praise from our ...
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γδ TCR Repertoires Analysis Services
Creative Biolabs concentrates on promoting the understanding of gamma delta (γδ) T cell receptors breakthroughs in disease therapy. We will combine γδ T cell receptor (TCR) repertoires analysis research with other incredible projects around the world to boost novel γδ T cell development in unprecedented ways. In our company, our scientists specialized in γδ T cell studies will work with you to develop the most appropriate strategy that will offer the ...
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Drug Development Consulting
Biological drugs are pharmaceutical drug product manufactured in, extracted from or semi synthesized from a living organism or from biological sources. Our professional scientists have rich experience in biological and pharmacological research of multiple biological drugs including peptide drugs, protein drugs, antibody drugs, antimicrobial drugs, vaccines as well as drugs involved in different therapeutic approaches such as immunotherapy, gene therapy ...
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Small Molecule Drug Development
mall molecule drugs are chemically synthesized active organic compounds with a low molecular weight usually less than 900 daltons which can be made into tablets or capsules that are easily absorbed. As traditional form of medicine, small molecule drugs have always been an important part of drug research and have irreplaceable places. Up to now, small molecule drugs involved in therapeutic use can be divided into small molecule inhibitors, small molecule ...
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Small Molecule Inhibitors
Small molecule inhibitors are a class of small molecules that interact with proteins and reduce the biological activity of target proteins. The structure of small molecule inhibitors has good spatial dispersion, and their chemical properties determine their good pharmacodinemic properties and pharmacokinetic properties. These characteristics make small molecule inhibitors show great advantages in drug research and development process, and these molecules ...
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Small Molecule Antagonists
Small molecule antagonists, or sometimes called blockers are substances that act against and block agonist-mediated effects. Antagonists themselves do not induce biological effects. Antagonists and agonists are key participants in the chemistry and ...
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Small Molecule Agonists
Agonists can induce excitatory or inhibitory responses and modulate or enhance the basal activity of tissues. Small molecule agonists are substances that can enhance another molecule's activity and therefore stimulate an action. Agonists often mimic the effects of natural substances. The action caused by agonists can be blocked by antagonists. Agonists and antagonists are key players in the chemistry of the human body and in ...
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Small Molecule Activators
Enzymes are macromolecules with biocatalytic function to accelerate chemical reactions. Enzymes are indispensable in various functions of living organisms and play key roles in almost every physiological/pathological process such as signal transduction, cell regulation, metabolism, activity control and digestion. Strict control of enzyme activity is essential for homeostasis. Any malfunction of key enzymes (mutation, overproduction, underproduction or ...
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Biological Drug Development
Biological drugs are macromolecules manufactured in, extracted from or semi synthesized by modern biotechnological methods within a living organism and can be composed of sugars, proteins, nucleic acids or complex combinations of these substances, or may be living cells or tissues. They are widely used in the diagnosis, treatment or prevention of diseases such as cancer, cardiovascular diseases, neurological diseases, autoimmune diseases and metabolic ...
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Peptide Drugs
Peptides mainly refer to molecules containing two to fifty amino acids linked by peptide bonds and molecularly poised between small molecules and proteins. The shortest peptides are dipeptides which consist of two amino acids joined by a single peptide bond. Long, continuous and unbranched peptide chains are called ...
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Protein Drugs
Protein drugs are protein products with certain biological activities for the prevention and diagnosis of diseases. They can be derived from plants and animals, or developed through biotechnology research. Protein drugs in a broad sense include all products whose chemical nature is protein or polypeptide, such as hormones, growth factors/cytokines, plasma proteins, enzymes, coagulation factors, antibodies, protein vaccines, ...
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Antibody Drugs
Antibody drugs which consist of antibody substances are prepared by antibody engineering technology based on cell and gene engineering technology. An important feature of antibody drugs is that they can be tailored making by genetic engineering and be prepared according to specific therapeutic needs. With the development of antibody genetic engineering technology, development of genetic engineered antibody as drug candidates is growing rapidly such as ...
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Antimicrobial Drugs
Microorganisms, also called microbes, are the collective name of all tiny organisms that are invisible to the naked eye. Harmful microorganisms are called pathogenic microorganisms which can cause diseases. Antimicrobial drugs refer to any substance that inhibits and kills pathogenic microorganisms and are used to treat infectious diseases. They can interfere with the life cycle of microorganisms and thereby impeding their growth and reproduction. ...
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Artificial Intelligence (AI) Assisted Platform
Over the past few years, artificial intelligence (AI) has been widely used in the pharmaceutical industry, because it can handle large volumes of data with enhanced ...
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AI-assisted Nucleic Acid Drugs Design Services
The nucleic acid drug, as a novel therapeutic modality, can achieve long-lasting or even curative effects via gene regulations, replacement or editing. They have great potential to treat human diseases such as viral infections, cancers, and genetic ...
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AI-assisted Protein Modeling Services
Generally, the structural information of protein is more valuable than sequence alone for determining its function. Through the three-dimensional (3D) structure of a protein, researchers can understand its biochemical function and interaction properties in molecular ...
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AI-assisted Toxicity Prediction Services
Because the use and production of chemical compounds may be directly harmful to humans, animals, plants, or the environment. Chemical toxicity and adverse effects have become key regulatory aspects for a multitude of ...
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AI-assisted ADMET Property Prediction
ADMET stands as an abbreviation for absorption, distribution, metabolism, excretion, and toxicity in pharmacokinetics and pharmacology. These properties describe the reaction of a drug medication within an organism, human, or animal, which helps scientists evaluate their drug candidates and select compounds that are likely to have the desired effects on ...
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AI-assisted Structure and Function Prediction
Bioinformatics is an interdisciplinary field of computer science, statistics, and life sciences. Based on the algorithms and professional software, bioinformatics can mine and interpret tremendous biological ...
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AI-assisted Quantum Chemical Calculation
The drug-discovery process is a trial-and-error run and time-consuming. Currently, using in silico tools to find a molecule that binds to the target protein has made computational chemistry a valuable tool in drug ...
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Project Assessment Services
Drug discovery has been considered as a high-cost and time-consuming process to treat different kinds of human ...
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Project Feasibility Assessment Services
Drug discovery and development is an attractive strategy for treating various human diseases. In particular, different types of drugs, such as vaccines, antibodies, have been generated and tested in many preclinical and clinical ...
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Project Management Service
We understand the critical importance of project management in ensuring the success of the drug development programs of our ...
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Cryo-Electron Microscopy
Creative Biolabs can provide custom structure determination services using cryo-electron microscopy for drug ...
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Small-Angle X-ray and Neutron Scattering
Creative Biolabs can provide custom structure determination services using small-angle X-ray and neutron scattering (SAXS and SANS) for drug ...
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Digital Imaging
Creative Biolabs can provide custom digital imaging services using several strategies for drug ...
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Electron Microscopy
Creative Biolabs can provide custom digital imaging services using electron microscopy with the advanced drug discovery services ...
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Fluorescence Microscopy
Creative Biolabs can provide custom digital imaging services using fluorescence microscopy in drug ...
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Confocal Laser Scanning Microscopy
Creative Biolabs can provide custom digital imaging services using confocal laser scanning microscopy with the advanced drug discovery ...
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Radioautography
Creative Biolabs can provide custom digital imaging services using radioautography for functional analysis of drug ...
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Metabolic Pathway Analysis for Fungi
Creative Biolabs can provide custom metabolic pathway analysis services for target identification and ...
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Target Localization
Creative Biolabs can provide custom high-quality drug target localization services for functional analysis in the process of drug ...
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Virtual Screening
Creative Biolabs offers virtual screening services for any ...
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Small-Angle X-ray and Neutron Scattering
Creative Biolabs can provide custom structure determination services using small-angle X-ray and neutron scattering (SAXS and SANS) for drug ...
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Digital Imaging
Creative Biolabs can provide custom digital imaging services using several strategies for drug ...
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Electron Microscopy
Creative Biolabs can provide custom digital imaging services using electron microscopy with the advanced drug discovery services ...
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Fluorescence Microscopy
Creative Biolabs can provide custom digital imaging services using fluorescence microscopy in drug ...
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Confocal Laser Scanning Microscopy
Creative Biolabs can provide custom digital imaging services using confocal laser scanning microscopy with the advanced drug discovery ...
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Atomic Force Microscopy
Creative Biolabs can provide custom digital imaging services using atomic force ...
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Radioautography
Creative Biolabs can provide custom digital imaging services using radioautography for functional analysis of drug ...
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Metabolic Pathway Analysis for Fungi
Creative Biolabs can provide custom metabolic pathway analysis services for target identification and ...
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Target Localization
Creative Biolabs can provide custom high-quality drug target localization services for functional analysis in the process of drug ...
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Virtual Screening
Creative Biolabs offers virtual screening services for any ...
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Fragment-Based Screening
Well-established binding assays for fragment-based hit ...
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Surface Plasmon Resonance (SPR) Spectrometry
Custom surface plasmon resonance (SPR) technology services for drug ...
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Thermal Shift Assay
Custom tailored thermal shift assay services with several applications of drug ...
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Biolayer Interferometry (BLI)
Custom high quality biolayer interferometry (BLI) technology services for drug ...
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Isothermal Titration Calorimetry (ITC)
Custom isothermal titration calorimetry services for drug ...
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Mass Spectrometry (MS)
Mass spectrometry service to support your drug discovery ...
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High Content Screening
Specialized in the development and implementation of high content ...
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High Throughput Flow Cytometry
High throughput flow cytometry (HTFC) for performing multiplexed cell-based and bead-based screens to meet your need for drug discovery ...
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Secondary Screening
An efficient secondary screening platform as complements to HTS ...
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Drug Abuse Liability
Drug abuse liability is the potential that a drug has properties that facilitate people becoming addicted or dependent on it. This phenomenon may be caused by drugs' pharmacological and psychopharmacological properties or social aspects around their self-administration. The addictive potency of drugs varies between different drugs. For instance, drugs such as heroin or cocaine have higher abuse liability than drugs like codeine or ...
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Evaluation of Chemical Similarity
structure characterization, physicochemical characterization, and mode of action (MOA) ...
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In Vivo PK Studies
Pharmacokinetics (PK) dedicated to determining the mechanisms of a drug's absorption, biodistribution, when it eliminated from the body and what it becomes. It is a study of how an organism affects a drug. In vivo PK studies are critical to ensure drug candidates have appropriate PK properties that can be evaluated in preclinical pharmacology and safety studies. In vivo PK studies provide required and useful information that indicates human equivalent ...
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Formulation Development
statistically designed experiment to understand formulation parameters that impact the safety, efficiency, manufacturability, and stability in primary ...
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Process and Scale-up
In general, the work done in a laboratory cannot be simply multiplied up to an industrial scale because of the inevitable consequences of increased scale, such as a decrease in surface area and volume ratio. This may seem insignificant in the lab (for example a bit of foam), but it may be significant at industrial scale (the bit of foam has its own structure and impedes the addition of other ...
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Reaction Condition Optimization
As new drugs are on the market constantly, the strategy to improve drug development and manufacturing processes becomes critical. In the development of pharmaceutical chemicals, it is increasingly important to improve product yields, reduce waste and cost by optimizing the reaction condition. At the same time, optimizing the reaction condition is part of a strategy to bring new chemical entities to market or extend existing product life ...
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Route Scouting and Development
New methods of synthesizing new compounds and new molecules are rapidly evolving, and more and more new technologies are emerging in the field of drug discovery. A right route is the key to ensuring the rapid development and supporting drug discovery project. A viable synthetic route is also required to meet all requirements, such as scalability, repeatability and cost ...
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Impurity Characterization and Management
Impurities in pharmaceuticals devices may come from raw materials, reaction byproducts, or residual solvents. The potential and concentration of these compounds are usually taken into account during the risk assessment. And those impurities or contaminants would cause unexpected reactions in these processes, which may affect the API synthesis step or the medical manufacturing stages and may also affect the final stability and shelf life of API or medical ...
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Pre-formulation Development
Formulation studies aim to develop a drug preparation which is both stable, safety and acceptable to the patient. Pre-formulation studies are an essential component of drug development process, and it provides the scientific basis for formulation development. It gives the physical, chemical, and mechanical properties of a new drug and helps researchers choose what ingredients (excipients) should be used in the ...
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Toxicity and Safety Evaluation
Prior to clinical trials, it is necessary to conduct animal toxicity studies to best characterize the potential toxicity of new drug candidates. Generally, the objective of preclinical safety evaluation is to determine the toxic effects with respect to target organs, dose dependency, the relationship between clinical findings and exposure to the compound, and potential reversibility of findings. All these data will be used to provide a safe starting ...
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Pharmacology and Pharmacodynamics Studies
Pharmacology and pharmacodynamics studies are of great importance in determining a drug's effect during drug discovery and development. A large variety of animal models has been developed to provide investigators with the ability to characterize the pharmacokinetics and pharmacodynamics of ...
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Rodent Behavioral Tests for Motor Function
Insults to the central nervous system can lead to severe motor impairments in gait or fine motor skills. To develop therapies for motor dysfunction, animal models which have a disease pathophysiology comparable to the clinical population are used. Smaller animals such as rodents are preferred by scientists due to various reasons, such as high reproduction rate and relatively low ...
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Cell Line Derived Tumor Xenograft (CDX) Mouse Models
Tumor-derived cell lines have long been used to discover the biologic processes in oncology, as well as screening platforms for discovering and evaluating the efficacy of anti-tumor ...
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Collagen-Induced Arthritis (CIA) Rodent Model
Rheumatoid arthritis (RA) is a typical, chronic autoimmune disease that primarily affects the joints, ultimately leading to synovitis that often develops into cartilage and bone erosion, apart from which, extra-articular features are presented, including subcutaneous nodules, vasculitis, and pulmonary fibrosis, particularly in severer cases. Of the various animal models of rheumatoid arthritis (RA), collagen induced arthritis (CIA) is the most widely ...
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Cecum Ligation and Puncture (CLP)-Induced Sepsis Model
Rodent disease models are widely used for a broad range of project objectives, which involve investigation of pathological process and mechanism of disease, pre-clinical tests of potential therapeutic agents, ...
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Pharmacokinetics Models
Pharmacokinetics (PK) models are generated to elucidate the transformations that a drug undergoes in an organism and the rules that determine this ...
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Rodent Duchenne Muscular Dystrophy (DMD) Model
DMD is a progressive muscle wasting disease that affects approximately 1 in 3500 male births. It is caused by mutations in a large 79-exon gene encoding the dystrophin protein. The majority of mutations identified in DMD are frameshift mutations that result in complete loss of dystrophin. Patients typically present at 2-5 years of age with a waddling gait, calf hypertrophy, and difficulties in rising from the floor.There is currently no cure for DMD and ...
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MOG35-55-Induced EAE Mice Model
Multiple Sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of human MS as it is especially useful to investigate neuroinflammatory pathways and often serves as a "proof-of-principle" model for the efficacy of novel treatment ...
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Introduction of MOG
Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is exclusively expressed in the CNS on the surface of myelin sheaths and oligodendrocyte processes. The function of MOG is not yet fully understood but synthetic peptide MOG35-55 is discovered to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. This autoantibody response to MOG35-55 has been ...
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Elevated Plus Maze Test
EPM is one of the most popular behavioral tests for research on anxiety, initially developed for rats and more recently for other species such as mice, guinea pigs. The test apparatus is raised above the floor and comprises two closed (dark, with walls) and two open arms (illuminated, without walls) that are arranged to form a plus shape. The test is based on the rodents' natural aversion to the open and elevated areas, which is reported to be caused by ...
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Allergic Rhinitis Model
Animal models have been making remarkable contributions to the understanding of genetics and immune-mediated pathophysiology of allergic rhinitis. Non-human primates (NHPs) exhibit plenty of similarities with humans in terms of physiology, anatomy, neurology and many other aspects. In particular, NHP have highly human immune systems in contrast to other animal species, which makes them very suitable objects for preclinical research of immunity-related ...
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Rodent Amyotrophic Lateral Sclerosis (ALS) Model
Amyotrophic lateral sclerosis is a neurodegenerative disorder leading to loss of voluntary muscle movement, paralysis, and eventually death. There is now an urgent need for the development of effective treatment for ...
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Nutritional Models of NAFLD/NASH
Nonalcoholic fatty liver disease (NAFLD), one of the most common chronic liver disease, is a condition characterized by abnormal excessive fat accumulation in the liver of a patient without a history of alcohol ...
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Nude Rat Xenograft Models
Nude rat xenograft models provide a more appropriate platform that conquers the limitations of traditional in vivo models and more precisely represent human cancer features especially in relation to metastasis and drug ...
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Rodent Atherosclerosis Models
Atherosclerosis is a chronic inflammatory condition that is the underlying factor of cardiovascular diseases. Both blood vessel walls and the immune system are implicated in atherogenesis. Plasma lipoproteins, genetics and the hemodynamics of the blood flow in the artery all play important roles in the development of atherosclerosis. Animal models are valuable tools for providing insights on the etiology and pathophysiology of this disease. They can be ...
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Beam Walking Test
A broad variety of rodent motor tests are available to determine deficits in animal models. The ‘beam walking test' or ‘balance beam test' is used to analyze rodent gait in a testing environment that challenges their ability to maintain balance given that the animals have to cross an elevated beam with a narrow ...
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Collagen Antibody-Induced Arthritis (CAIA) Model
Rheumatoid arthritis (RA) is a typical, chronic autoimmune disease that primarily affects the joints, ultimately leading to synovitis that often develops into cartilage and bone erosion, apart from which, extra-articular features are presented, including subcutaneous nodules, vasculitis, and pulmonary fibrosis, particularly in severer ...
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Carrageenan-Induced Paw Edema Model
The acute inflammatory response is well-known to be characterized by increased vascular permeability, increased blood flow, as well as infiltration of neutrophils and macrophages. Moreover, an edema is often formed due to exudation of fluid and plasma proteins and accumulation of leukocytes at the inflammatory site. To date, several experimental models of paw edema have been described by investigators. As one of the best characterized acute inflammatory ...
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Inflammation Models Induced by Carrageenan
The acute inflammatory response is well-known to be characterized by increased vascular permeability, increased blood flow, as well as infiltration of neutrophils and macrophages. Moreover, an edema is often formed due to exudation of fluid and plasma proteins and accumulation of leukocytes at the inflammatory site. To date, several experimental models of paw edema have been described by investigators. As one of the best characterized acute inflammatory ...
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Rodent Neurological Disorder Models
Rodent models of Central Nervous System (CNS) disorders are widely used to explore pathology and molecular mechanisms, identify potential biomarkers, and to assess the therapeutic utility and estimate safety margins of new disease-specific ...
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adenoviral vector vaccines
Advances in recombinant DNA technology, genomics and immunology have greatly affected the vaccine development ...
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adenovirus vaccines
Type 5 adenovirus, belonging to species C adenoviruses, is a linear double-stranded DNA virus with a diameter of about 80-120 ...
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allergy vaccines
Allergic diseases are prevalent worldwide. Allergen Immunotherapy (AIT) is a current treatment for allergic diseases, leading to modification of the natural course of the ...
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attenuated vaccines
A live attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or ...