29 Articles found
Creative BioMart Articles
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Unveiling the Intricacies of DNM1L: Function, Associated Diseases, and Inheritance Patterns
Introduction The human body is a complex network of genes and proteins, each playing a crucial role in maintaining our health. One such gene, DNM1L, has garnered significant attention in recent years due to its vital functions and its association ...
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Unveiling the Role of CDH1 Protein in Cancer and Future Research Directions
Introduction CDH1, also known as E-cadherin, is a crucial protein involved in cell adhesion and plays a significant role in various biological processes. In recent years, researchers have focused on understanding the functions of CDH1 and its ...
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Protein Engineering: Designing Molecular Machines for a Healthier Future
Proteins are the workhorses of life, performing a vast array of essential functions, from catalyzing biochemical reactions to building and maintaining cellular structures. Protein engineering, a rapidly evolving field at the intersection of biology, ...
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Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these ...
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The C-Myc Oncogene Is Associated with Aging, New Study Found
The Myc gene is one of the most important drivers of cancer in mice and humans. Myc also plays a newly discovered key role in aging, according to a new study in Cell Reports by researchers at UPMC Children's Hospital of Pittsburgh and the University ...
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Revealing the molecular mechanism of mutant protein-induced melanoma in the body
The RNA surveillance pathway detects and interprets defective transcripts to ensure RNA fidelity. Recently, in a research report entitled "Oncogenic CDK13 mutations impede nuclear RNA surveillance" published in Science, scientists from Howard Hughes ...
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It turns out that p53 is destroyed in a whole new way
Glioblastoma is a deadly brain cancer with a dire prognosis. Unlike most cancers, it still grows in the presence of the p53 protein. Scientists have been unable to solve the case for decades...until now. CSHL scientists have discovered that a ...
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A regulatory network of Sox and Six transcription factors support auditory cell regeneration
Researchers at the National Institutes of Health have identified a specific network of proteins necessary for zebrafish cells to regenerate and restore hearing. Researchers at the National Human Genome Research Institute (NHGRI) led the study, which ...
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CAR-T Cell Anti-Cancer Therapy Ushered in A Revolutionary Breakthrough!
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. In particular, CAR-T therapy, which has been approved by the FDA, is rewriting the ...
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A Plant Immune Protein May be Expected to Completely Cure Cancer!
Cancer, caused by abnormal cell proliferation, is one of the world's major public health problems. Recently, in a research report entitled "A plant immune protein enables broad antitumor response by rescuing microRNA deficiency" published in Cell, ...
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Alcohol relapse is linked to immune protein?
Scientists at the Scripps Research Institute have found that the immune protein CSF1 may cause anxiety during alcohol withdrawal. Some nuclei have the corticotropin-releasing factor receptor 1 crhr1 gene, and the glutamate transporter slc17a7 gene, ...
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Effect of interferon receptor pathway on CAR-T cell-mediated killing of solid tumors
Researchers at Massachusetts General Hospital (MGH) have found that interferon gamma receptor (IFNgR) signaling is essential for the susceptibility of CAR-T cell immunotherapy to kill malignant gliomas. The same phenomenon has been observed in other ...
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A Novel Potential Target for CAR-T Cell Therapy in Human Solid Tumors Discovered
At present, chimeric antigen receptor T cell therapy (CAR-T) has made significant achievements in the treatment of specific hematological cancers, allowing patients with relapsed/refractory disease to survive longer and become healthier, but in ...
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides ...
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How Much Do You Know about Bacteriocin?
In recent years, the increase in the number of multi-drug resistant pathogens and food safety have become serious global problems, and it is increasingly important to find or develop a new generation of antibacterial drugs or preservatives. ...
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Protein PPARd Can Induce Rapid Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
In a new study, researchers from the Icahn School of Medicine at Mount Sinai have developed a reproducible and scalable method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), and hPSC-CMs produced by human ...
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New findings! Egr1 is a target for the treatment of fibrotic nephropathy
Epigenetic modifications play a crucial role in various biological processes and diseases, and DNA methylation is an important mechanism of epigenetic inheritance. DNA methyltransferases (DNMT1, DNMT3a, and Dnmt3b) are involved in the generation and ...
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Revealing the Details of Changes in Spike Proteins of SARS-CoV-2 Omicron Mutant Strains
The interesting SARS-CoV-2 omicron mutant strain evades immunity mediated by antibodies from vaccination or infection with early mutants due to the accumulation of a large number of spike mutations. Recently, in a research report titled "Structural ...
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Mapk4 May Be a New Target for the Treatment of Triple-Negative Breast Cancer
There is now growing evidence that the MAPK4 enzyme may be involved in cancer growth and resistance to specific therapies. Recently, an article titled " MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K ...
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Novel Biomarkers May Help Predict the Susceptibility of a Population to Rheumatoid Arthritis
Genetics (i.e., mutations) are considered to be the main factor predisposing to the etiology of rheumatoid arthritis (RA), but they account for only a few changes in RA disease risk, and in contrast to genetics, the environment may have an important ...