3 products found
Evox Therapeutics Limited Products
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Pipeline - Internal Programs
Evox’s internal program largely focus on Inborn Errors of Metabolism (IEMs), which are genetic conditions that result from problems in metabolising proteins, carbohydrates, fats, or other substances. In most of these disorders, disease manifestations arise due to the accumulation of substances which are toxic or interfere with the normal function of metabolism.
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Evox - Argininosuccinic Aciduria (ASA)
Argininosuccinic aciduria (ASA) is a rare genetic disorder characterized by a deficiency or lack of the enzyme argininosuccinate lyase ...
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Evox - Model Type I - Citrullinemia
The second urea cycle disorder indication to be targeted by Evox is Citrullinemia type I, which is caused by a mutation in the ASS1 gene leading to a deficiency in hepatic enzyme arginosuccinate synthetase (ASS) that results in high levels of citrulline and ammonia in the ...
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Evox - Model PKU - Phenylketonuria Phenylalanine Metabolism
Phenylketonuria, or PKU, is an autosomal recessive inborn error of phenylalanine metabolism resulting in a deficiency of the hepatic enzyme phenylalanine hydroxylase ...