11 products found
HTG Molecular Diagnostics, Inc. Products
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Gene Expression Panels
Our expertly curated gene expression panels leverage the power and sensitivity of next-generation sequencing, allowing you to measure the expression levels of a few hundred genes to whole mRNA and miRNA transcriptome. Our breakthrough technology generates results from clinically relevant samples, such as formalin-fixed, paraffin-embedded (FFPE) tissue, to support biomarker discovery, drug targeting, and diagnostics development.
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HTG - Model HTP - Transcriptome Panel
The HTG Transcriptome Panel (HTP) is expertly designed to provide extensive coverage of most human mRNA transcripts including isoforms. The panel can simultaneously interrogate 19,398 targets using Formalin Fixed Paraffin Embedded (FFPE) samples, generating data for up to 96 samples in less than three days. HTP utilizes our proprietary workflow and leverages the sensitivity and dynamic range of next-generation sequencing (NGS), allowing researchers to ...
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HTG - EdgeSeq ALKPlus Assay EU Panels
The HTG EdgeSeq ALKPlus Assay EU is an in vitro diagnostic (IVD), next-generation sequencing (NGS)-based assay intended to measure and analyze mRNA ALK gene fusion events in formalin-fixed, paraffin-embedded (FFPE) lung tumor specimens from patients previously diagnosed with non-small cell lung cancer (NSCLC). The HTG EdgeSeq ALKPlus Assay EU utilizes our automated HTG EdgeSeq system coupled with the sensitivity and dynamic range of next-generation ...
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HTG - EdgeSeq DLBCL Cell of Origin Assay EU
The HTG EdgeSeq DLBCL Cell of Origin Assay EU is an in vitro diagnostic assay that uses gene expression profiling (GEP) to determine the cell of origin (COO) subtype of diffuse large B-cell lymphoma (DLBCL) tumors from formalin-fixed, paraffin-embedded (FFPE) tissue section. The gene expression data are assessed by a classification algorithm and the tumor samples determined to be of the activated B-cell like (ABC), germinal B-cell ...
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HTG EdgeSeq - miRNA Whole Transcriptome Assay
The HTG EdgeSeq miRNA Whole Transcriptome Assay (miRNA WTA) enables users to measure the expression of 2,083 human miRNA transcripts using next-generation sequencing (NGS). The HTG EdgeSeq chemistry is compatible with fixed tissue samples, biofluids, and cell lines. The miRNA WTA utilizes our automated HTG EdgeSeq system coupled with the sensitivity and dynamic range of NGS-based detection and can be performed in your lab using the HTG EdgeSeq system, ...
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Therapeutics
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HTG - Therapeutics Technology
The initial focus of HTG Therapeutics will be to identify development candidates targeting RNA or RNA modifying proteins, which could be relevant in areas such as oncology, immunology, diabetes, and rare disease. HTG’s EdgeSeq and Epi-EdgeSeq technology is a foundational element in our drug discovery programs. It enables a more highly resolved view of the transcriptome, especially aberrations in physiological states leading to disease. Utilizing ...
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HTG - Drug Discovery Process System
HTG Therapeutics will combine deep transcriptome mining expertise with an array of medicinal chemistry computational filters to construct custom libraries for the screening of compelling molecular targets. Screening these targets, including phenotypic approaches, will create a pipeline of early-stage discovery programs to be optimized into development candidates for diseases with significant unmet therapeutic ...
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Gene Expression Profiling Panels - Systems
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HTG EdgeSeq - Chemistry System
HTG EdgeSeq assays employ nuclease protection to measure RNA. Target-specific protection probes with universal priming sites (wings) hybridize to target transcripts and wingman (1). S1 nuclease is added to digest non-hybridized probes and RNA, resulting in a 1-to-1 ratios of probes and target RNAs (2). After S1 nucleuse inactivation (3), the remaining probes are amplified with primers carrying sequencing adaptors and molecular barcodes (4). The resulting ...
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HTG EdgeSeq - System Simplifies Gene Expression Profiling
The HTG EdgeSeq processor, assays, and parser software facilitate analysis of gene expression profiles from a wide variety of specimen types to accelerate discovery, support translational applications and evaluate target biomarkers for companion diagnostics. Our extraction-free specimen preparation and quantitative nuclease protection chemistry assays automate preparation of mRNA and miRNA targets for library preparation and next-generation sequencing ...
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HTG EdgeSeq - Workflow Solutions Empower Precision Medicine
The HTG EdgeSeq processor, assays, and parser software produce gene expression profiles from a wide variety of specimen types to accelerate discovery, support translational studies, and evaluate target biomarkers for companion diagnostic development. Our solutions enable fast, reliable, reproducible, and quantitative analysis of thousands of targeted RNAs from a single assay in as little as 36 hours with reduced hands-on ...
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Gene Expression Profiling Panels - HTG EdgeSeq RUO Panels
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HTG EdgeSeq - Model OBP - Oncology Biomarker Panel
The HTG EdgeSeq Oncology Biomarker Panel (OBP) is a systems biology pathway analysis tool that profiles samples to identify therapeutic targets and drug response markers. The OBP assay utilizes our automated HTG EdgeSeq system coupled with the sensitivity and dynamic range of next-generation sequencing (NGS)-based detection, and can be performed in your lab using the HTG EdgeSeq system, from our VERI/O lab as a service, or at one of the Qualified Service ...
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HTG - Model EdgeSeq - Precision Immuno-Oncology Panel
The next-generation sequencing (NGS)-based HTG EdgeSeq Precision Immuno-Oncology Panel is designed to measure the immune response both inside the tumor and the surrounding microenvironment. HTG’s quantitative nuclease protection assay does not require nucleic acid extraction and is automated using the HTG EdgeSeq processor. By leveraging the high sensitivity and dynamic range of NGS instrumentation, this powerful tool interrogates 1,392 genes from a ...