Lena Biosciences, Inc. products

GradientEZ is a system for 3D cell migration and invasion assays. It enables parallel testing of multiple modulators of cell invasion in a single well. Cells can be isolated for quantitative results or fluorescently labeled and imaged in real time.

GradientEZ is a qualitative cell migration and invasion assay that enables cells to migrate in three dimensions as they do in living tissues. It is straightforward to use and works like a piece of paper. Simply, pipet cells in the center and add test agents to petals or lobes to model gradient-dependent pathological conditions in 3D. Alternatively, add invasive cancer cells to the center and normal cells to lobes. Fluorescently labeled cells or cell populations added to the center or lobes may be imaged and analyzed in real time during or after cell migration studies using fluorescence microscopy. Suitable for both adherent and suspension cells.

GradientEZ is a system for 3D cell migration and invasion assays. It enables parallel testing of multiple modulators of cell invasion in a single well. Cells can be isolated for quantitative results or fluorescently labeled and imaged in real time. Petal design is ideally suited for extended nerve regeneration studies.

The POP microphysiological system is a lab technology that combines the 3D cell culturing capabilities of our SeedEZ scaffold with the advanced oxygenation and pH stability of our Blood Substitute within a compact, perfused multi-well insert plate, PerfusionPal.  The system is ideally suited for modeling interstitial perfusion that cells in most tissues experience in vivo, and the majority of tumors bigger than 2 mm. With our proprietary Blood Substitute that mimics the functions of hemoglobin, pericellular perfusion carries sufficient amount of respiratory gases to enable long-term cell survival and improved cell functions in vitro.

Lena Biosciences offers a robust 3D cell culture system for routine, predictive testing in vitro. SeedEZ is a three-dimensional cell culture scaffold made of randomly oriented, inert glass microfibers. The diameter of microfibers is carefully optimized for long-term cell growth and repeat-dose drug testing. The microfibers are arranged in such a way that creates tiny pores for nutrients, gases, and metabolites to pass through the scaffold allowing normal cell functions.