Mimetas B.V. products

OrganoReady® Colon Caco-2 offers 38 ready-to-use Caco-2 tubules for drug exposure, transport, and permeability studies. The product is based on the OrganoPlate® 3-lane 40 with 3 adjacent channels per chip, including one perfused Caco-2 tubule. OrganoReady® Caco-2 comprises 38 ready-to-use Caco-2 tubules for drug exposure, transport, and permeability studies. Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Colon Caco-2 you can now easily take your intestinal research to the next level. Perform your self-created experiments to investigate permeability, absorption and transport, toxicity, and barrier integrity (TEER) in a physiologically relevant model.

OrganoReady® Blood Vessel HUVEC comprises 38 ready-to-use HUVEC tubules for drug exposure, transport, and permeability studies. The product is based on the OrganoPlate® 3-lane 40 with 3 adjacent channels per chip, including one perfused HUVEC tubule. Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Blood Vessel HUVEC you can now take your vascular research to the next level. Perform your self-created experiments to investigate permeability, absorption and transport, toxicity, and barrier integrity (TEER) in a physiologically relevant model.

OrganoReady® Angiogenesis HUVEC comprises 64 HUVEC tubules ready-to-sprout. The product is based on the OrganoPlate® 3-lane 64 with 3 adjacent channels per chip, including one perfused HUVEC tubule. Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Angiogenesis HUVEC you can now take your angiogenesis research to the next level. Create and set up your desired studies such as compound profiling, screening or subsequently investigate sprouting behavior.

Profiling and screening of your compounds with a high throughput barrier integrity assay on our established Caco-2 intestinal model. OrganoServices are available for multiple assays to allow compound profiling and/or screening in human-relevant, complex 3D tissue models. When developing new drugs, it is critical to understand the permeability, absorption, and transport mechanisms in relevant biological systems. An important prerequisite to study this is the epithelial barrier function. To assess the barrier function of epithelia in vitro electrical measurement of the impedance is the golden standard. We developed a barrier integrity assay using Caco-2 intestinal tubules cultured in the OrganoPlate® together with the recently introduced OrganoTEER®, that measures the transepithelial electrical resistance (TEER) of perfused epithelial tubes.