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Aquaculture

Endotoxins - LPS Endotoxicity Modulator

Endotoxins are toxic compounds from bacterial origin. The most well-known endotoxins are lipopolysaccharides (LPS), which are part of the cell wall of Gram-negative bacteria (e.g. E. coli, Salmonella). LPS  from all Gram-negative bacteria, commensal or pathogenic, share the same chemical structure, being an outer O-polysaccharide, an inner R-polysaccharide  and a lipid A moiety. The latter carriers the endotoxic activity of LPS and leads to the activation of the immune system. This lipid A endotoxicity varies between different bacteria and depends on several structural factors.